NCT03817632

Brief Summary

Prospective, multicenter, observational, comparative clinical trial on the equivalence of two different OrthoPilot® navigation system generations applied for computer-assisted total knee arthroplasty

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
217

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2019

Typical duration for all trials

Geographic Reach
1 country

3 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 23, 2019

Completed
2 days until next milestone

First Posted

Study publicly available on registry

January 25, 2019

Completed
5 months until next milestone

Study Start

First participant enrolled

July 1, 2019

Completed
3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2022

Completed
4 months until next milestone

Study Completion

Last participant's last visit for all outcomes

October 29, 2022

Completed
Last Updated

January 17, 2023

Status Verified

January 1, 2023

Enrollment Period

3 years

First QC Date

January 23, 2019

Last Update Submit

January 13, 2023

Conditions

Keywords

NavigationComputer Assisted Orthopedic SurgeryOrthoPilot®Total Knee Arthroplasty

Outcome Measures

Primary Outcomes (1)

  • Rate of Lower Limb Alignment inside the range of 0±3°

    A postoperative lower limb alignment of the knee prosthesis in reference to the mechanical leg axis (3, 18) outside the range of ± 3° is defined as the outlier. The outlier rates will be used as the efficacy criterion for groups comparison

    three months postoperatively

Secondary Outcomes (7)

  • Lower limb alignment of the knee prosthesis in reference to the mechanical leg axis

    3 months postoperatively

  • Improvement of Knee Society Score (KSS)

    preoperatively and three months postoperatively

  • Improvement of Oxford Knee Score (OKS)

    preoperatively and three months postoperatively

  • Improvement of Quality of Life (EQ-5D-5L)

    preoperatively and three months postoperatively

  • Learning Curve

    Intraoperatively

  • +2 more secondary outcomes

Study Arms (2)

A Standard

Computer assisted primary total knee replacement with OrthoPilot FS 101 navigation system and Software 5.1

Device: Computer assisted primary total knee replacement with OrthoPilot FS101 navigation system and Software 5.1

B Elite

Computer assisted primary total knee replacement with OrthoPilot Elite navigation system and Software 6.0

Device: Computer assisted primary total knee replacement with OrthoPilot Elite navigation system and Software 6.0

Interventions

Computer Assisted Total Knee Replacement with the OrthoPilot FS101 and the software TKA 5.1

A Standard

Computer Assisted Total Knee Replacement with the with the OrthoPilot Elite and the software TKA 6.0

B Elite

Eligibility Criteria

Age18 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

adult patients

You may qualify if:

  • Patients with indication for Total Knee Arthroplasty using the Aesculap OrthoPilot® navigation system and a corresponding primary implant
  • Dated and signed informed consent

You may not qualify if:

  • Pregnancy
  • Patients \< 18 years
  • Patients unable to participate at the follow-up examination (physically, mentally)
  • Previous joint replacement at the indexed knee

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (3)

Universitätsklinikum Carl Gustav Carus

Dresden, 01307, Germany

Location

Uniklinikum Freiburg

Freiburg im Breisgau, 79106, Germany

Location

Schönkliniken Klinikum Eilbek

Hamburg, 22081, Germany

Location

MeSH Terms

Conditions

Joint DiseasesArthritis, RheumatoidJoint Instability

Condition Hierarchy (Ancestors)

Musculoskeletal DiseasesArthritisRheumatic DiseasesConnective Tissue DiseasesSkin and Connective Tissue DiseasesAutoimmune DiseasesImmune System Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 23, 2019

First Posted

January 25, 2019

Study Start

July 1, 2019

Primary Completion

June 30, 2022

Study Completion

October 29, 2022

Last Updated

January 17, 2023

Record last verified: 2023-01

Locations