Changes in Elastic Properties of Descending Thoracic Aorta After Ascending Aorta Replacement
Impact of Ascending Aorta Replacement by Graft on Elastic Properties of Descending Thoracic Aorta Evaluated by Cardiac Magnetic Resonance Imaging
1 other identifier
observational
19
0 countries
N/A
Brief Summary
The aim of our study was to evaluate the impact of aortic root replacement by a graft on the elastic properties of the descending thoracic aorta using cardiac Magnetic Resonance Imaging (MRI) and automatic post-processing. Nineteen patients were operated on an aortic root aneurysm and a cardiac MRI allowing aortic compliance measurement was performed before and after surgery. Images were acquired with a 1.5 T MRI with only one additional sequence to a conventional aortic MRI protocol.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Sep 2014
Longer than P75 for all trials
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2014
CompletedFirst Submitted
Initial submission to the registry
January 17, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 17, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
January 17, 2019
CompletedFirst Posted
Study publicly available on registry
January 25, 2019
CompletedJanuary 25, 2019
January 1, 2019
4.4 years
January 17, 2019
January 24, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Aortic compliance of descending aorta (mm2/mmHg)
Aortic elastic properties of the descending aorta before and after aortic root replacement using cardiac MRI. Aortic compliance is a local measurement of elastic properties which is obtained with cardiac MRI images by computer processing.
post-operative cardiac MRI performing between 12 and 24 months
Secondary Outcomes (1)
Aortic compliance of ascending aorta (mm2/mmHg)
post-operative cardiac MRI performing between 12 and 24 months
Interventions
Patient with planned Ascending aorta replacement with graft
Eligibility Criteria
19 patients operated in Cardiac Surgery unit of DIJON Hospital between September 2014 and December 2017.
You may qualify if:
- \> 18 years
- Elective patient
- Ascending aorta replacement with graft
You may not qualify if:
- Prior cardiac surgery
- Contraindication to performing cardiac MRI
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Centre Hospitalier La Chartreuselead
- JAZAYERI Alinecollaborator
- BOUCHOT Oliviercollaborator
- JAZAYERI Saedcollaborator
- MALAPERT Ghislaincollaborator
- PETROSYAN Andreanikcollaborator
Related Publications (1)
Morgant MC, Miteran J, Lin S, Laubriet A, Cochet A, Lalande A, Bouchot O. Impact of ascending aorta replacement by graft on elastic properties of descending thoracic aorta evaluated by cardiac magnetic resonance imaging. MAGMA. 2020 Oct;33(5):641-647. doi: 10.1007/s10334-020-00829-5. Epub 2020 Jan 31.
PMID: 32006121DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PI
Study Record Dates
First Submitted
January 17, 2019
First Posted
January 25, 2019
Study Start
September 1, 2014
Primary Completion
January 17, 2019
Study Completion
January 17, 2019
Last Updated
January 25, 2019
Record last verified: 2019-01
Data Sharing
- IPD Sharing
- Will not share