Selective Attention in Alcohol Use Disorder

NCT03816527 | Withdrawn

• 1 other identifier: Emo-Dotprobe
• Study Type: observational
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This study examines the selective attention to emotional- and alcohol- associated cues in alcohol- dependant and healthy participants.

Conditions

Alcohol Use Disorder

Outcome Measures

Primary Outcomes (2)

• attentional bias to alcohol cues

  measured with reaction time differences (in milliseconds) using the dotprobe-task (Vollstädt-Klein et al. 2009) \[reaction time differences is not a change over time; it is measured during one experimental session\]

  at examination 1 day (single examination, no follow-up)

• attentional bias to emotional cues

  measured with reaction time differences (in milliseconds) using the dotprobe-task (like in Vollstädt-Klein et al. 2009, but with emotional pictures) \[reaction time differences is not a change over time; it is measured during one experimental session\]

  at examination 1 day (single examination, no follow-up)

Secondary Outcomes (6)

• severity of nicotine dependence

  at examination 1 day (single examination, no follow-up)

• nicotine consumption

  at examination 1 day (single examination, no follow-up), retrospectively for the last 3 months

• alcohol consumption

  at examination 1 day (single examination, no follow-up), retrospectively for the last 3 months

• severity of alcohol use disorder

  at examination 1 day (single examination, no follow-up),

• habitual alcohol consumption

  at examination 1 day (single examination, no follow-up), retrospectively for the last 7 days

Study Arms (2)

AUD patients

Individuals with alcohol use disorder

Healthy controls

Healthy controls

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

group 1: patients with alcohol use disorder, recruited in the Clinic of the Department of Addictive Behaviour and Addiction Medicine group 2: healthy controls, recruited from the local community

You may qualify if:

• Women of childbearing age
• Women an Men between 18 and 65 years
• Adequate ability to reach an Agreement with the Investigator, to answer oral and written questions
• Ability to consent after detailed reconnaissance
• Written informed consent
• Patients: Diagnosis of alcohol use disorder

You may not qualify if:

• Participants wich are unable to consent
• Severe internal, neurological ans psychiatric comorbidities
• Abstinence phenomenon (CIWA-R \> 3)
• Axis I psychiatric disorder (except nicotine dependence and specific phobias within the last 12 months as well as patients with alcohol use disorder)
• Pharmacotherapy with psychoactive substances

Sponsors & Collaborators

• Central Institute of Mental Health, Mannheim: lead

Study Sites (1)

Klinik für Abhängiges Verhalten, Zentralinstitut für Seelische Gesundheit

Mannheim, Germany

Location

MeSH Terms

Conditions

Alcoholism

Condition Hierarchy (Ancestors)

Alcohol-Related Disorders; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Officials

• Sabine Vollstädt-Klein

  ZI Mannheim

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 7, 2019
• First Posted: January 25, 2019
• Study Start: January 1, 2019
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: May 1, 2025

Record last verified: 2025-04

Locations

DE (1)