NCT03811561

Brief Summary

This study will look at the long-term effects of semaglutide (active medicine) on diabetic eye disease when compared to placebo (dummy medicine). The study will be performed in people with type 2 diabetes. Participants will either get semaglutide or placebo in addition to their diabetes medicines - which treatment the participant gets is decided by chance. Participants will inject the study medicine using a pen-injector. The medicine must be injected in a skin fold in the stomach, thigh or upper arm once a week. The study will last for 5 years.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
1,500

participants targeted

Target at P75+ for phase_3 diabetes-mellitus-type-2

Timeline
19mo left

Started May 2019

Longer than P75 for phase_3 diabetes-mellitus-type-2

Geographic Reach
19 countries

229 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress82%
May 2019Nov 2027

First Submitted

Initial submission to the registry

January 18, 2019

Completed
4 days until next milestone

First Posted

Study publicly available on registry

January 22, 2019

Completed
4 months until next milestone

Study Start

First participant enrolled

May 8, 2019

Completed
8.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 7, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 7, 2027

Last Updated

April 30, 2026

Status Verified

April 1, 2026

Enrollment Period

8.5 years

First QC Date

January 18, 2019

Last Update Submit

April 29, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Presence of at least 3 steps Early Treatment Diabetic Retinopathy Study (ETDRS) subject level progression.

    Percentage of subjects (yes/no).

    Year 5

Secondary Outcomes (21)

  • Time from randomisation to first at least 3 steps ETDRS subject level progression or central involved diabetic macular oedema (ciDME) in either eye.

    Up to 5 years

  • Change in visual acuity in the worse seeing eye.

    Week 0, Year 5

  • Change in visual acuity in the better seeing eye.

    Week 0, Year 5

  • Occurrence of treatment for diabetic retinopathy or diabetic macular oedema in either eye with focal/grid laser photocoagulation.

    Week 0-Year 5

  • Occurrence of treatment for diabetic retinopathy or diabetic macular oedema in either eye with pan-retinal laser photocoagulation.

    Week 0-Year 5

  • +16 more secondary outcomes

Study Arms (2)

Semaglutide

EXPERIMENTAL

Participants will receive semaglutide once weekly as subcutaneous (s.c., under the skin) injection added to standard of care.

Drug: Semaglutide

Placebo

PLACEBO COMPARATOR

Participants will receive placebo (semaglutide) once weekly as subcutaneous subcutaneous (s.c., under the skin) injection added to standard of care.

Drug: Placebo (semaglutide)

Interventions

Participants will get one dose of semaglutide once weekly in addition to their diabetes medicines - which treatment they get is decided by chance. Participants will inject the study medicine using a pre-filled PDS290 pen-injector. The medicine must be injected in a skin fold in the stomach, thigh or upper arm once a week. Participants will start with once-weekly doses of 0.25 mg for 4 weeks, then the dose will be gradually increased to 0.5 mg once weekly for 4 weeks, and finally to 1.0 mg once weekly (maximum dose) up to 260 weeks (5 years).

Semaglutide

Participants will get one dose of placebo (semaglutide) once weekly in addition to their diabetes medicines - which treatment they get is decided by chance. Participants will inject the study medicine using a pre-filled PDS290 pen-injector. The medicine must be injected in a skin fold in the stomach, thigh or upper arm once a week. Participants will start with once-weekly doses of 0.25 mg for 4 weeks, then the dose will be gradually increased to 0.5 mg once weekly for 4 weeks, and finally to 1.0 mg once weekly (maximum dose) up to 260 weeks (5 years).

Placebo

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Male or female, age greater than or equal to 18 years at the time of signing informed consent
  • Diagnosed with type 2 diabetes mellitus.
  • HbA1c of 7.0-10.0% (53-86 mmol/mol) (both inclusive).
  • Early Treatment Diabetic Retinopathy Study (ETDRS) level of 10-75 (both inclusive) evaluated by fundus photography and confirmed by central reading centre
  • No ocular or intraocular treatment for diabetic retinopathy or diabetic macular oedema six months prior to the day of screening.
  • No anticipated need for ocular or intraocular treatment for diabetic retinopathy or diabetic macular oedema within three months after randomisation.
  • Best-corrected visual acuity greater than or equal to 30 letters using the ETDRS visual acuity protocol
  • No previous treatment with pan-retinal laser photocoagulation
  • No substantial non-diabetic ocular condition that, in the opinion of the ophthalmologist, would impact diabetic retinopathy or diabetic macular oedema progression during the trial
  • No substantial media opacities that would preclude successful imaging

You may not qualify if:

  • Any of the following: myocardial infarction, stroke, hospitalization for unstable angina pectoris or transient ischaemic attack within the past 60 days prior to the day of screening
  • Planned coronary, carotid or peripheral artery revascularisation known on the day of screening
  • Subjects presently classified as being in New York Heart Association (NYHA) Class IV
  • Renal impairment measured as estimated Glomerular Filtration Rate (eGFR) value of eGFR less than 30 ml/min/1.73 m\^2
  • Personal or first degree relative(s) history of multiple endocrine neoplasia type 2 or medullary thyroid carcinoma
  • Presence or history of malignant neoplasms within the past 5 years prior to the day of screening. Basal and squamous cell skin cancer and any carcinoma in-situ are allowed
  • Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using highly effective contraceptive methods
  • Concurrent treatment with any GLP-1 receptor agonist or DPP-4 inhibitor from randomisation.
  • Receipt of any investigational medicinal product within 30 days before screening
  • Previous participation in this trial. Participation is defined as randomisation
  • Known or suspected hypersensitivity to trial products or related products
  • Any disorder, which in the investigator's opinion might jeopardise subject's safety or compliance with the protocol

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (229)

Synexus Rsch /Cnt Phnx Med C

Phoenix, Arizona, 85050, United States

Location

Del Sol Research Management, LLC

Tucson, Arizona, 85715, United States

Location

South Arizona VA Healthcare System

Tucson, Arizona, 85723, United States

Location

Synexus Cln Rsrch Inc - Orange Gro FP

Tucson, Arizona, 85741, United States

Location

Southern California Res Ctr

Coronado, California, 92118, United States

Location

FDRC

Costa Mesa, California, 92627, United States

Location

Advanced Investigative Medicine, Inc.

Hawthorne, California, 90250, United States

Location

Diabetes/Lipid Mgmt & Res Ctr

Huntington Beach, California, 92648, United States

Location

Scripps Whittier Diabetes Inst

La Jolla, California, 92037, United States

Location

Torrance Clin Res Inst, Inc.

Lomita, California, 90717, United States

Location

Angel City Research, Inc.

Los Angeles, California, 90010, United States

Location

Downtown LA Res Ctr. Inc.

Los Angeles, California, 90017, United States

Location

Riverside University Health System Medical Center

Moreno Valley, California, 92555, United States

Location

Rancho Cucamonga Clinical Research

Rancho Cucamonga, California, 91730-3063, United States

Location

Clinical Trials Research_Sacramento_0

Sacramento, California, 95821, United States

Location

UCLA Diabetes Center at Santa Monica

Santa Monica, California, 90404, United States

Location

Coastal Metabolic Research Center

Ventura, California, 93003, United States

Location

Diablo Clinical Research, Inc.

Walnut Creek, California, 94598, United States

Location

Barbara Davis Center

Aurora, Colorado, 80045, United States

Location

Rocky Mount Reg VA Med-DN

Aurora, Colorado, 80045, United States

Location

Chase Medical Research LLC

Waterbury, Connecticut, 06708, United States

Location

Innovative Research of W FL

Clearwater, Florida, 33756, United States

Location

Est Cst Inst for Rsrch,Jksnvil

Jacksonville, Florida, 32216, United States

Location

Reyes Clinical Research, Inc

Miami, Florida, 33175, United States

Location

Renstar Medical Research

Ocala, Florida, 34471, United States

Location

Atlanta Diabetes Associates

Atlanta, Georgia, 30318, United States

Location

Endo Res Solutions Inc

Roswell, Georgia, 30076, United States

Location

Apex Medical Research Inc

Chicago, Illinois, 60607, United States

Location

The University Of Chicago

Chicago, Illinois, 60637, United States

Location

American Health Network of Indiana, LLC_Avon

Avon, Indiana, 46123, United States

Location

American Health Network of Indiana, LLC_Greenfield

Greenfield, Indiana, 46140, United States

Location

Iowa Diab & Endo Res Center

West Des Moines, Iowa, 50266, United States

Location

VA Medical Center

Lexington, Kentucky, 40502, United States

Location

Kentucky Diabetes-Endocrinology Center

Lexington, Kentucky, 40503, United States

Location

The Research Group of Lexington LLC

Lexington, Kentucky, 40503, United States

Location

L-MARC Research Center

Louisville, Kentucky, 40213, United States

Location

Four Rivers Clinical Research Inc

Paducah, Kentucky, 42001, United States

Location

MedStar Hlth Res Institute

Hyattsville, Maryland, 20782, United States

Location

Brigham & Women's Hospital

Boston, Massachusetts, 02115, United States

Location

Boston Medical Center_Cary

Boston, Massachusetts, 02118, United States

Location

Joslin Center For Diabetes

Boston, Massachusetts, 02215, United States

Location

Joslin Diabetes Center

Boston, Massachusetts, 02215, United States

Location

Michigan Medicine

Ann Arbor, Michigan, 48105, United States

Location

Synexus Clinical Research US, Inc._Tempe_0

Richfield, Minnesota, 55432, United States

Location

Diabetes & Endo Specialists Inc

Chesterfield, Missouri, 63017, United States

Location

Palm Research Center Inc-Vegas

Las Vegas, Nevada, 89148, United States

Location

Southern New Hampshire Diabete

Nashua, New Hampshire, 03060, United States

Location

Lovelace Scientific Resources Inc

Albuquerque, New Mexico, 87108, United States

Location

University of New Mexico

Albuquerque, New Mexico, 87131, United States

Location

NYC Research, Inc.

New York, New York, 10016, United States

Location

Mountain Diabetes & Endocrine Center

Asheville, North Carolina, 28803, United States

Location

University of North Carolina

Chapel Hill, North Carolina, 27514, United States

Location

OnSite Clinical Solutions, LLC

Charlotte, North Carolina, 28226, United States

Location

Your Diabetes Endocrine Nutrition Group, Inc.

Mentor, Ohio, 44060, United States

Location

University of Toledo Medical Center

Toledo, Ohio, 43614, United States

Location

Harold Hamm Diabetes Center

Oklahoma City, Oklahoma, 73104, United States

Location

Aria Endocrine Metabolic Assoc

Philadelphia, Pennsylvania, 19114, United States

Location

Tristar Clin Investigations, PC

Philadelphia, Pennsylvania, 19114, United States

Location

Holston Medical Group Pc

Bristol, Tennessee, 37620-7352, United States

Location

Univ Diab & Endo Consultants

Chattanooga, Tennessee, 37411, United States

Location

Holston Medical Group

Kingsport, Tennessee, 37660, United States

Location

Vanderbilt Diab Obes Clin Tri

Nashville, Tennessee, 37212, United States

Location

Central Texas Clinical Research

Austin, Texas, 78705, United States

Location

Texas Diab & Endo, P.A.

Austin, Texas, 78731, United States

Location

Velocity Clinical Res-Dallas

Dallas, Texas, 75230, United States

Location

UT Southwestern Med Cntr

Dallas, Texas, 75390-9302, United States

Location

Clinical Trials of Texas, LLC

San Antonio, Texas, 78229, United States

Location

VIP Trials

San Antonio, Texas, 78230, United States

Location

Consano Clinical Research, LLC

Shavano Park, Texas, 78231, United States

Location

Simcare Medical Research, LLC

Sugar Land, Texas, 77478, United States

Location

Synexus Clinical Research US, INC.

Murray, Utah, 84107, United States

Location

MultiCare Inst for Res & Innov

Spokane, Washington, 99202, United States

Location

CPQuali Pesquisa Clínica Ltda

São Paulo, São Paulo, 01228-000, Brazil

Location

DCC I- Pleven EOOD Endocrinology

Pleven, 5801, Bulgaria

Location

MHAT Sveti Pantaleimon - Pleven, Internal Diseases

Pleven, 5806, Bulgaria

Location

MHAT Med Line Clinic

Plovdiv, 4000, Bulgaria

Location

UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Endocrinology

Plovdiv, 4002, Bulgaria

Location

MHAT MC-Sv Ivan Rilski EOOD

Plovdiv, 4003, Bulgaria

Location

"DCC VII - Sofia", Endocrinology Consulting Room

Sofia, 1233, Bulgaria

Location

DCC VII - Sofia EOOD, Endocrinology

Sofia, 1233, Bulgaria

Location

MHAT Knyaginya Klementina - Sofia EAD

Sofia, 1233, Bulgaria

Location

USHATE Akad. Ivan Penchev EAD, Second Clinic of Endocrinology

Sofia, 1431, Bulgaria

Location

IV MHAT - Sofia EAD

Sofia, 1606, Bulgaria

Location

DCC XX - Sofia EOOD, Endocrinology

Sofia, 1618, Bulgaria

Location

Medical centre Vitclinic EOOD

Sofia, 1680, Bulgaria

Location

Alberta Diabetes Institute

Edmonton, Alberta, T6G 2E1, Canada

Location

LMC Clinical Res Thornhill

Concord, Ontario, L4K 4M2, Canada

Location

LMC Endo Ctr (Etobicoke) Ltd

Etobicoke, Ontario, M9R 4E1, Canada

Location

LMC Oakville

Oakville, Ontario, L6M 1M1, Canada

Location

The Ottawa Hospital Riverside Campus

Ottawa, Ontario, K1H7W9, Canada

Location

LMC Endo Centres Ltd.(Bayview)

Toronto, Ontario, M4G 3E8, Canada

Location

LMC Clinical Research, Inc. (Montreal Glen)

Montreal, Quebec, H4A 2C6, Canada

Location

Centricity Res Pointe-Claire

Pointe-Claire, Quebec, H9R 4S3, Canada

Location

LMC Clin Rsrch Inc. (Montreal)

Saint-Laurent, Quebec, H4T 1Z9, Canada

Location

Fakultni nemocnice Brno

Brno, 62500, Czechia

Location

Fakultni nemocnice Hradec Kralove

Hradec Králové, 500 05, Czechia

Location

Diabetologie Krupska

Prague, 100 00, Czechia

Location

Fakultni nemocnice Kralovske Vinohrady_Praha

Prague, 100 34, Czechia

Location

Institut klinicke a experimentalni mediciny

Prague, 140 00, Czechia

Location

MUDr. Michala Pelikanova

Prague, 140 00, Czechia

Location

Praxis Denger/Pfitzner, Friedrichsthal

Friedrichsthal, 66299, Germany

Location

Diabetologische Schwerpunktpraxis Harburg- Dr. med.Paschen,

Hamburg, 21073, Germany

Location

Diabetes-Zentrum-Wilhelmsburg GbR

Hamburg, 21109, Germany

Location

Wendisch - Dahl Hamburg - DZHW

Hamburg, 22607, Germany

Location

Wendisch/Dahl Hamburg

Hamburg, 22607, Germany

Location

Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

Münster, 48145, Germany

Location

MedicalCenter am Clemenshospital - Schwerpunktpraxis für Diabetologie und Ernährungsmedizin

Münster, 48153, Germany

Location

Praxis Dr. med. Wenzl-Bauer

Rehlingen-Siersburg, 66780, Germany

Location

Zentrum für klinische Studien Alexander Segner

Saint Ingbert-Oberwürzbach, 66386, Germany

Location

University Hospital of Athens ATTIKON

Athens, Attica, 12462, Greece

Location

Iatriko Psychicou Private Clinic

Athens, 115 25, Greece

Location

"Laiko" General Hospital of Athens

Athens, 11527, Greece

Location

"Laiko" General Hospital of Athens

Athens, GR-11527, Greece

Location

Iatriko Athinon 'Palaiou Falirou'

Athens, GR-17562, Greece

Location

University Hospital of Athens ATTIKON

Haidari-Athens, GR-12462, Greece

Location

"Ippokrateio" G.H. of Thessaloniki

Thessaloniki, 54642, Greece

Location

"Thermi" Private Hosital

Thessaloniki, 57001, Greece

Location

"Thermi" Private Hosital

Thessaloniki, GR-57001, Greece

Location

Endolife Specialty Hospitals

Guntur, Andhra Pradesh, 522001, India

Location

Nirmal Hospital Pvt. Ltd.

Surat, Gujarat, 395002, India

Location

Narayana Hrudayalya Institute of Cardiac Sciences

Bangalore, Karnataka, 560 099, India

Location

Diacon Hospital Private Limited

Bangalore, Karnataka, 560010, India

Location

Amrita Institute Of Medical Sciences & Research Centre

Kochi, Kerala, 682041, India

Location

Indian Institute of Diabetes

Thiruvananthapuram, Kerala, 695031, India

Location

Indian Institute of Diabetes

Thiruvnanthapuram, Kerala, 695033, India

Location

BYL Nair Hospital and T N Medical College Department of endo

Mumbai, Maharashtra, 400008, India

Location

Seth GS medical college and KEM Hospital

Mumbai, Maharashtra, 400012, India

Location

Government Medical College and Super Speciality Hospital, Nagpur

Nagpur, Maharashtra, 440009, India

Location

DEW Medicare & Trinity hospital

Nagpur, Maharashtra, 440015, India

Location

Deenanath Mangeshkar Hospital & Research Centre

Pune, Maharashtra, 411004, India

Location

All India Institute of Medical Sciences

Ansari Nagar, New Delhi 110029, New Delhi, 110029, India

Location

Apollo Hospital

Delhi, New Delhi, 110076, India

Location

Indraprastha Apollo Hospital

Delhi, New Delhi, 110076, India

Location

All India Institute of Medical Sciences

New Dehli, New Delhi, 110029, India

Location

Dayanand Medical College & Hospital_Ludhiana

Ludhiana, Punjab, 141001, India

Location

Christian Medical College and Hospital

Ludhiana, Punjab, 141008, India

Location

Madras Diabetes Research Foundation

Chennai, Tamil Nadu, 600086, India

Location

Arthur Asirvatham hospital,

Madurai, Tamil Nadu, 625 020, India

Location

SSKM

Kolkata, West Bengal, 700020, India

Location

Apollo Gleneagles Hospital

Kolkata, West Bengal, 700054, India

Location

Apollo Multispeciality Hospital, Kolkata

Kolkata, West Bengal, 700054, India

Location

Care Hospital

Hyderabad, 600034, India

Location

Aditya Jyot Hospital

Mumbai, 400031, India

Location

Rambam MC - Diabetes and obesity center of excellence

Haifa, 31096, Israel

Location

Hadassah Ein Karam MC - Diabetes Unit

Jerusalem, 91120, Israel

Location

Meir MC - Diabetes unit

Kfar Saba, 44281, Israel

Location

Rabin MC Beilinson - Endo unit

Petah Tikva, 49100, Israel

Location

Sourasky MC - Institute of Endocrinology, metabolism and hypertension

Tel Aviv, 64239, Israel

Location

Sheba MC - Endocrinology Clinic

Tel Litwinsky, 52621, Israel

Location

Zemgales diabetes centre

Jelgava, 3001, Latvia

Location

Teterovska practice

Ogre, 5001, Latvia

Location

P. Stradins Clinical University Hospital

Riga, 1002, Latvia

Location

Medical Centre Pulss 5

Riga, 1011, Latvia

Location

Juglas Medicine Center

Riga, LV-1024, Latvia

Location

Instituto Nacional de Nutricion - Unidad de Inv de Enf Metab

Distrito Federal, México, D.F., 14080, Mexico

Location

Hospital Universitario Dr. José Eleuterio González_Monterrey

Monterrey, Nuevo León, 64460, Mexico

Location

Uniwersytecki Szpital Kliniczny w Bialymstoku

Bialystok, Podlaskie Voivodeship, 15-276, Poland

Location

In-Vivo Sp. z o.o.

Bydgoszcz, 85-048, Poland

Location

B_Serwis Popenda Sp.J.

Chorzów, 41-500, Poland

Location

Synexus Polska Sp. z o.o. Oddzial w Gdansku

Gdansk, 80-382, Poland

Location

NZOZ Gdanska Poradnia Cukrzycowa Sp.z o.o.

Gdansk, 80-858, Poland

Location

Centrum Medyczne Pratia Katowice

Katowice, 40-081, Poland

Location

Clinical Medical Research Korfantego - Ambulatoryjna Opieka

Katowice, 40-156, Poland

Location

FutureMeds Sp. z o.o.

Krakow, 31-501, Poland

Location

Santa Sp. z o.o, Santa Familia Centrum Badan, Profilaktyki i Leczenia

Lodz, 90-302, Poland

Location

Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.

Lodz, 90-338, Poland

Location

Prywatny Gabinet Lekarski Jan Ruxer

Lodz, 94-047, Poland

Location

NZOZ "DiabMed" Poradnia Diabetologiczna

Poznan, 60-821, Poland

Location

Maciej Wiza Gaja Poradnie Lekarskie

Poznan, 61-251, Poland

Location

SPZZOZ im. Marszalka J. Pilsudskiego w Plonsku

Płońsk, 09-100, Poland

Location

SPSK nr 1 im. prof. Stanisława Szyszko Śląskiego Uniwersytetu Medycznego w Katowicach, ul. 3-go Maja 13/15 41-800 Zabrze

Zabrze, 41-800, Poland

Location

Santa Sp. z o.o, Santa Familia Centrum Badan, Profilaktyki i Leczenia

Lodz, Łódź Voivodeship, 90-302, Poland

Location

ULS De Matosinhos E.P.E.- Hospital Pedro Hispano

Senhora Da Hora, Matosinhos, Matosinhos, 4464-513, Portugal

Location

ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta

Almada, 2805-267, Portugal

Location

ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro

Aveiro, 3814-501, Portugal

Location

Unidade De Coimbra, E.P.E. - Hospital da Universidade de Coimbra

Coimbra, 3000-561, Portugal

Location

ULS Do Alto Ave, E.P.E. - Hospital Senhora da Oliveira - Guimarães

Guimarães, 4835-044, Portugal

Location

APDP - Associação Protectora dos Diabéticos de Portugal

Lisbon, 1250-230, Portugal

Location

Centro Hospitalar de São João

Porto, 4200-319, Portugal

Location

ULS De São João, E.P.E. - Hospital de São João

Porto, 4200-319, Portugal

Location

ULS Da Arrábida, E.P.E._Hospital de São Bernardo

Setúbal, 2910-446, Portugal

Location

Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila

Bucharest, Bucharest, 020475, Romania

Location

Clinic of Diabetes Cluj

Cluj-Napoca, Cluj, 400006, Romania

Location

SC Centru Medical Dr. Negrisanu SRL

Timișoara, Timiș County, 300456, Romania

Location

3rd Clinic for Nutrition-Spitalulul Județean de Urgenta

Timișoara, Timiș County, 300736, Romania

Location

"Carol Davila" Military Emergency Hospital

Bucharest, 010825, Romania

Location

Sana Monitoring SRL

Bucharest, 011025, Romania

Location

SC Clinica Diabnutrimed S.R.L.

Bucharest, 020359, Romania

Location

Multispecialty Medical Clinic Anturium LLC

Barnaul, 656043, Russia

Location

Kazan Federal University

Kazan', 420012, Russia

Location

PIH "Clin Hosp "RZD-Medicina" former Kazan OJSC Rus Railways

Kazan', 420061, Russia

Location

Kazan Federal University

Kazan', 420097, Russia

Location

FSBI 'I.I. Dedov National Medical Research Center of Endocrinology' of the MH of Russia

Moscow, 117292, Russia

Location

National Medical Research Center of Endocrinology

Moscow, 117292, Russia

Location

Branch of limited liability company "Hadassah Medical LTD"

Moscow, 143026, Russia

Location

State Novosibirsk regional clinical hospital

Novosibirsk, 630087, Russia

Location

City Consultative & Diagnostic Centre #1

Saint Petersburg, 194354, Russia

Location

Diagnistic Centre "Energo"

Saint Petersburg, 196084, Russia

Location

Consultative & Diagnostic Center with a Outpatient Hospital

Saint Petersburg, 197110, Russia

Location

Llc "International Medical Center "Time"

Saint-Peterburg, 194044, Russia

Location

SHI Saratov City Clinical Hospital #9

Saratov, 410031, Russia

Location

Regional clinical cardiology dispensary

Saratov, 410039, Russia

Location

Sverdlovsk Regional Clinical Hospital #1

Yekaterinburg, 620102, Russia

Location

Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.

Novi Sad, Vojvodina, 21000, Serbia

Location

CHC Zvezdara, Clinical department for endocrinology

Belgrade, 11000, Serbia

Location

Endocrinology, Diabetes and Metabolism Diseases Clinic

Belgrade, 11000, Serbia

Location

Clinical Hospital Center Bezanijska Kosa

Belgrade, 11080, Serbia

Location

Clinical Centre Nis, Endocrinology, Diabetes and Metabolism

Niš, 18000, Serbia

Location

V. interna klinika LF UK a UNB

Bratislava, 82606, Slovakia

Location

Nemocnica akademika L. Derera, UNB

Bratislava, 833 05, Slovakia

Location

Diabetologicka ambulancia, Dia Zilina s.r.o.

Žilina, 01001, Slovakia

Location

Medivasa s.r.o., Diabetologicka ambulancia

Žilina, 01001, Slovakia

Location

MEDIVASA, s.r.o., Diabetologicka ambulancia

Žilina, 01001, Slovakia

Location

Complejo Hospitalario Universitario A Coruña

A Coruña, 15006, Spain

Location

Hospital Vall d'Hebron

Barcelona, 08035, Spain

Location

Hospital de Bellvitge

L'Hospitalet de Llobregat, 08907, Spain

Location

Clinica Universitaria de Navarra

Pamplona, 31008, Spain

Location

Hospital Virgen de la Macarena

Seville, 41009, Spain

Location

Hospital La Fe - Endocrinología y Nutrición

Valencia, 46026, Spain

Location

Harrogate District Hospital

Harrogate, North Yorkshire, HG2 7SX, United Kingdom

Location

Queen's Medical Centre University Hospital

Nottingham, Nottinghamshire, NG7 2UH, United Kingdom

Location

University Hospital, Queens Medical Centre

Nottingham, Nottinghamshire, NG7 2UH, United Kingdom

Location

Yeovil Hospital

Yeovil, Somerset, BA21 4AT, United Kingdom

Location

King's College Hospital

London, SE5 9RS, United Kingdom

Location

Norfolk and Norwich University Hospital

Norfolk, NR4 7UQ, United Kingdom

Location

George Eliot Hospital NHS Trust

Nuneaton, CV10 7DJ, United Kingdom

Location

George Eliot Hospital

Nuneaton, CV10 7DJ, United Kingdom

Location

Clinical Research Unit

Somerset, BA21 4AT, United Kingdom

Location

Royal Cornwall Hospital (Treliske)

Truro, TR1 3LJ, United Kingdom

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Interventions

semaglutide

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Study Officials

  • Clinical Reporting Anchor and Disclosure (1452)

    Novo Nordisk A/S

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
Sponsor staff involved in the clinical trial is masked according to company standard procedures.
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 18, 2019

First Posted

January 22, 2019

Study Start

May 8, 2019

Primary Completion (Estimated)

November 7, 2027

Study Completion (Estimated)

November 7, 2027

Last Updated

April 30, 2026

Record last verified: 2026-04

Data Sharing

IPD Sharing
Will share

According to the Novo Nordisk disclosure commitment on novonordisk-trials.com

More information

Locations