Short and Long Term Prognosis of Patients Admitted to the ED With Acute Heart Failure

NCT03806972 | Recruiting DMC

• 1 other identifier: CRF
• Study Type: observational
• Target: 3,000
• Locations: 1 country
• Sites: 1

Brief Summary

Heart failure (HF) is the leading cause of hospitalization ,rehospitalization and mortality for adults over 65 years of age. This study aimed to assess mortality, and hospitalization rates at 30 days and one year after dicharge of patients with heart failure (HF) with reduced ejection fraction (HFrEF) compared to HF with preserved ejection fraction (HFpEF).

Conditions

Acute Heart Failure

Keywords

acute heart failure prognosis

Outcome Measures

Primary Outcomes (1)

• Death or readmission rates

  A composite outcome of Death or readmission within 365 days of hospital discharge

  within 365 days after hospital discharge

Secondary Outcomes (1)

• Death or readmission rates

  within 30 days after hospital discharge

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study included all patients ,with either reduced ejection fraction (HFrEF) defined as LVEF \<45% or preserved ejection fraction (HFpEF) defined as LVEF ≥45% ,admitted to the ED of Monastir from 2009 with a principal discharge diagnosis code for HF. The diagnosis of HF categories should rely on the recent transthoracic echocardiographic findings and clinical judgement according to the guidelines.Collected data include clinical features biological markers (BNP or NTpro BNP) and echocardiography findings. The diagnosis of HF categories should rely on the recent transthoracic echocardiographic findings and clinical judgement according to the guidelines. A follow-up period of at least 1 year was required to notice all cause mortality and preferably HF-specific rehospitalization .

You may qualify if:

• patients admitted to the ED of Monastir with a principal discharge diagnosis code for HF.

You may not qualify if:

• Pregnant or breast feeding women. Alteration of consciousness GCS \< 15 Critically ill patients needing immediate mechanical hemodynamic of ventilatory support.
• Inability to follow instructions or comply with follow-up procedures.

Sponsors & Collaborators

• University of Monastir: lead

Study Sites (1)

Emergency Departement

Monastir, Monastir Governorate, 5000, Tunisia

RECRUITING

Related Publications (2)

• Castello LM, Molinari L, Renghi A, Peruzzi E, Capponi A, Avanzi GC, Pirisi M. Acute decompensated heart failure in the emergency department: Identification of early predictors of outcome. Medicine (Baltimore). 2017 Jul;96(27):e7401. doi: 10.1097/MD.0000000000007401.

  PMID: 28682895 BACKGROUND

• Searle J, Frick J, Mockel M. Acute heart failure facts and numbers: acute heart failure populations. ESC Heart Fail. 2016 Jun;3(2):65-70. doi: 10.1002/ehf2.12092. Epub 2016 Apr 25.

  PMID: 27818780 BACKGROUND

Study Officials

• Nouira Semir, Professor

  university Hospital of Monastir

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Nouira Semir, Professor

CONTACT

73106000; semir.nouira@rns.tn

Bel haj Ali Khaoula, MD

CONTACT

29777277; belhajalikhaoula@yahoo.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: January 15, 2019
• First Posted: January 16, 2019
• Study Start: June 1, 2009
• Primary Completion (Estimated): December 1, 2030
• Study Completion (Estimated): December 1, 2030
• Last Updated: July 22, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)