The Validity of Peripheral Perfusion Index to Predict Fluid Responsiveness
1 other identifier
observational
57
1 country
1
Brief Summary
Fluid therapy is an essential component of the management of patients with acute circulatory failure. Nevertheless, unnecessary administration of fluids in non-responders is harmful. Thus, the concept of fluid responsiveness has been suggested to guide fluid administration in critically ill patients to avoid either over or under-transfusion. The aim of this work is to investigate the ability of peripheral perfusion index to predict the hemodynamic response to mini-fluid challenge in patients with septic shock .
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 11, 2019
CompletedFirst Posted
Study publicly available on registry
January 15, 2019
CompletedStudy Start
First participant enrolled
January 27, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 25, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2019
CompletedDecember 23, 2020
December 1, 2020
5 months
January 11, 2019
December 21, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Peripheral perfusion index
It is a number describing the ratio between pulsatile and non-pulsatile blood flow measured by pulse oximeter. It is measured in percent. with the best value of 20% and the worst value of 0.1%
2 hours
Secondary Outcomes (6)
Velocity time integral
2 hours
Mean arterial blood pressure
2 hours
Central venous pressure
2 hours
Systolic arterial blood pressure
2 hours
Diastolic arterial blood pressure
2 hours
- +1 more secondary outcomes
Eligibility Criteria
The study will include septic shock patients undergoing fluid resuscitation. Patients will be enrolled during evaluation of fluid responsiveness.
You may qualify if:
- Septic shock patients
You may not qualify if:
- Evident blood loss
- Peripheral vascular disorders
- Upper limb injury or burns
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Cairo Universitylead
Study Sites (1)
Ahmed Mohamed Hasanin
Cairo, 11432, Egypt
Related Publications (1)
Hasanin A, Karam N, Mukhtar AM, Habib SF. The ability of pulse oximetry-derived peripheral perfusion index to detect fluid responsiveness in patients with septic shock. J Anesth. 2021 Apr;35(2):254-261. doi: 10.1007/s00540-021-02908-w. Epub 2021 Feb 22.
PMID: 33616758DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Ahmed Shash, Professor
Head of department of anesthesia, Cairo University, Egypt
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant professor of anesthesia and critical care
Study Record Dates
First Submitted
January 11, 2019
First Posted
January 15, 2019
Study Start
January 27, 2019
Primary Completion
June 25, 2019
Study Completion
July 1, 2019
Last Updated
December 23, 2020
Record last verified: 2020-12
Data Sharing
- IPD Sharing
- Will not share