Comparative Analysis of Serum Lipid Profiles in Patients With and Without Gallstones

NCT03804775 | Completed

• 1 other identifier: s10
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Gallbladder disease is one of the most common diseases of the gastrointestinal tract. Various studies have shown an association between gallstones and an alteration in the serum lipids. The objective of this study will be to compare serum lipid profile of gallstone patients with the controls.

Conditions

Gallstone; Dyslipidemias

Outcome Measures

Primary Outcomes (4)

• serum cholesterol levels

  serum cholesterol levels of patients and case group will be compared with Students t- test was (p\<0.05 will be considered statistically significant)

  1 week

• serum triglyceride levels

  serum triglyceride levels of gallstone patients and control group will be compared via student t-test (p\<0.05 was considered statistically significant)

  1 week

• serum HDL levels

  serum HDL levels of patients and contoled will be compared with student t-test (p\<0.05 was considered statistically significant)

  1 week

• serum LDL leves

  serum LDL leves of patients and control will be compared through student t-test (p\<0.05 was considered statistically significant)

  1 week

Study Arms (2)

case group

patients presenting with gallstone disease

Diagnostic Test: Serum lipid profile

control group

inpatients with no history of gallstones

Diagnostic Test: Serum lipid profile

Interventions

Serum lipid profile DIAGNOSTIC_TEST

Blood samples drawn from the patients and controls will be analyzed for serum cholesterol, serum triglycerides, serum LDLs and serum HDL levels. All the results will be recorded on a performa

case group; control group

Eligibility Criteria

• Age: 20 Years - 70 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Case group: patients from lahore city presented with gallstone disease in Services Hospital lahore Control group: Patients admitted to Services Hospital with other diseases belonging from lahore

You may qualify if:

• Male or female patients with the gall stone disease
• Age from 20 to 70 years
• Gallstones were diagnosed through the ultrasound

You may not qualify if:

• Patients with acalculous gallbladder disease on ultrasound,
• Patients with terminal ileal resection,
• Patients with hemolytic diseases (hereditary spherocytosis, sickle cell anemia on history and CBC film),
• Patients with liver cirrhosis (on abdominal ultrasound) and
• Patients on antihyperlipidemic drugs

Sponsors & Collaborators

• Services Hospital, Lahore: lead

Study Sites (1)

Services hospital

Lahore, Punjab Province, 54000, Pakistan

Location

MeSH Terms

Conditions

Gallstones; Dyslipidemias

Condition Hierarchy (Ancestors)

Cholelithiasis; Biliary Tract Diseases; Digestive System Diseases; Cholecystolithiasis; Gallbladder Diseases; Calculi; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Mahmmood Ayyaz, mbbs, fcps

  Services Hospital, Lahore

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principle investigator

Study Record Dates

• First Submitted: January 9, 2019
• First Posted: January 15, 2019
• Study Start: August 1, 2017
• Primary Completion: August 30, 2018
• Study Completion: August 30, 2018
• Last Updated: January 15, 2019

Record last verified: 2019-01

Locations

PA (1)