Fatty Acid Biomarkers of Carbohydrate Intake

NCT03295448 | Completed

• 1 other identifier: CARBIO
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The overall aim is to investigate if circulating fatty acids and lipids are influenced by alterations in carbohydrate amount and quality.

Conditions

Dyslipidemias

Keywords

fatty acids; biomarker; carbohydrate; lipogenesis

Outcome Measures

Primary Outcomes (1)

• Palmitic acid in different plasma fractions

  Measured by liquid gas chromatography (GC)

  14-20 days

Secondary Outcomes (1)

• Even-chain saturated fatty acids (i.e. 14:0, 18:0) and monounsaturated fatty acids

  14-20 days

Other Outcomes (1)

• Desaturation indices end lipogenic indices

  14-20 days

Study Arms (6)

Fat - Sugar - Fiber

ACTIVE COMPARATOR

Intervention: consuming diets rich in fat, rich in sugar, and rich in fibers during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Other: Low carbohydrate diet; Other: High carbohydrate, high sugar diet; Other: High carbohydrate, low sugar diet

Fat - Fiber - Sugar

ACTIVE COMPARATOR

Intervention: consuming diets rich in fat, rich in fiber, and rich sugar during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Other: Low carbohydrate diet; Other: High carbohydrate, high sugar diet; Other: High carbohydrate, low sugar diet

Sugar - Fiber - Fat

ACTIVE COMPARATOR

Intervention: Consuming diets rich in sugar, rich in fiber, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Other: Low carbohydrate diet; Other: High carbohydrate, high sugar diet; Other: High carbohydrate, low sugar diet

Sugar - Fat - Fiber

ACTIVE COMPARATOR

Intervention: Consuming diets rich in sugar, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Other: Low carbohydrate diet; Other: High carbohydrate, high sugar diet; Other: High carbohydrate, low sugar diet

Fiber - Sugar - Fat

ACTIVE COMPARATOR

Intervention: Consuming diets rich in fiber, rich in sugar, and rich in fat during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Other: Low carbohydrate diet; Other: High carbohydrate, high sugar diet; Other: High carbohydrate, low sugar diet

Fiber - Fat - Sugar

ACTIVE COMPARATOR

Intervention: consuming diets rich in fiber, rich in fat, and rich in fiber during treatment periods 1, 2, and 3, respectively. Treatment periods are separated by one week of habitual diet.

Other: Low carbohydrate diet; Other: High carbohydrate, high sugar diet; Other: High carbohydrate, low sugar diet

Interventions

Low carbohydrate diet OTHER

Diet low in carbohydrates (38%E), but higher in total and saturated fat.

Fat - Fiber - Sugar; Fat - Sugar - Fiber; Fiber - Fat - Sugar; Fiber - Sugar - Fat; Sugar - Fat - Fiber; Sugar - Fiber - Fat

High carbohydrate, high sugar diet OTHER

Diet high in carbohydrates (53%E) and sugars, but low in wholegrain, rye and wheat fibre.

Fat - Fiber - Sugar; Fat - Sugar - Fiber; Fiber - Fat - Sugar; Fiber - Sugar - Fat; Sugar - Fat - Fiber; Sugar - Fiber - Fat

High carbohydrate, low sugar diet OTHER

Diet high in carbohydrates (53%E), wholegrain, rye and wheat fibre, but low in sugars.

Fat - Fiber - Sugar; Fat - Sugar - Fiber; Fiber - Fat - Sugar; Fiber - Sugar - Fat; Sugar - Fat - Fiber; Sugar - Fiber - Fat

Eligibility Criteria

• Age: 20 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• BMI 20-38

You may not qualify if:

• abnormal lab tests (assessed by screening and judged by a physician), diabetes, cardiovascular, kidney, liver or malignant disease, and weight-loss (±3kg) the preceding 3 months of screening. Extreme diets, i.e. very-low carbohydrate diets, intermittent fasting, vegan diets or allergic to gluten

Sponsors & Collaborators

• Uppsala University: lead

Study Sites (1)

Uppsala univeristy hospital

Uppsala, 75185, Sweden

Location

Related Publications (1)

• Bajahzer MF, Rosqvist F, Friden M, Iggman D, Pingel R, Marklund M, Riserus U. Contrasting Carbohydrate Quantity and Quality and the Effects on Plasma Saturated and Monounsaturated Fatty Acids in Healthy Adults: A Randomized Controlled Trial. J Nutr. 2023 Mar;153(3):683-690. doi: 10.1016/j.tjnut.2023.01.005. Epub 2023 Jan 13.

  PMID: 36797136 DERIVED

MeSH Terms

Conditions

Dyslipidemias

Interventions

Diet, Carbohydrate-Restricted

Condition Hierarchy (Ancestors)

Lipid Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Diet Therapy; Nutrition Therapy; Therapeutics; Diet; Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Officials

• Ulf Riserus, PhD

  Uppsala University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 22, 2017
• First Posted: September 27, 2017
• Study Start: October 25, 2017
• Primary Completion: June 1, 2018
• Study Completion: June 1, 2018
• Last Updated: November 15, 2018

Record last verified: 2018-11

Locations

SE (1)