Multiple Biomarkers in ICU Sepsis Patients
Prognostic Value of Early Oxidative Stress Biomarkers in Patients With Sepsis
1 other identifier
observational
120
1 country
1
Brief Summary
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Dec 2018
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
December 30, 2018
CompletedFirst Submitted
Initial submission to the registry
January 2, 2019
CompletedFirst Posted
Study publicly available on registry
January 14, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2019
CompletedJanuary 14, 2019
January 1, 2019
5 months
January 2, 2019
January 11, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
presence of AKI
Use serum creatinine or urine output（The KDIGO Guidelines 2012) to asess whether AKI happens to the studied subjects within a week after admission to ICU
a week after admission to ICU
Death of the patients
Mortality of the studied patients
2 weeks after admission to ICU
Secondary Outcomes (1)
Use serum creatinine to assess renal function of the patients
the 1 day when the patients admitted to ICU
Study Arms (2)
high concentration of biomarkers
the patients with biomarkers level over the normal max value
low concentration of biomarkers
the patients with biomarkers level below the normal max value
Eligibility Criteria
patients admitted to ICU of Zhongnan Hospital
You may qualify if:
- sepsis patients in appropriate age
You may not qualify if:
- ever blood transfusion ever CPR（cardiopulmonary resuscitation)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, 430000, China
Biospecimen
serum and centrifuged urine will be retained in a -80℃ fridge
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
zhiyong peng, professor
Zhongnan Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- professor
Study Record Dates
First Submitted
January 2, 2019
First Posted
January 14, 2019
Study Start
December 30, 2018
Primary Completion
June 1, 2019
Study Completion
June 1, 2019
Last Updated
January 14, 2019
Record last verified: 2019-01