Predicting Pancreatic Necrosis Using mitDNA
Study of Plasma mitDNA in Predicting Pancreatic Necrosis in Acute Pancreatitis
1 other identifier
observational
25
0 countries
N/A
Brief Summary
Multiple predictors have been used for early pancreatic necrosis, prediction, detection, and monitoring. These include clinical score systems and circulating biomarkers. Ranson and APACHE II score systems are widely used albeit complex and time-consuming. Recently, the role of circulating biomarkers . Of these novel biomarkers, only CRP has been used routinely in cases of pancreatic necrosis prediction. Mitochondrial DNA (mtDNA) is an extra chromosomal genome occurring in the mitochondria of eukaryotic cells. High levels of mtDNA suggest the presence of pancreatic necrosis and close observation should be given to avoid the development of SAP and pancreatitis infection.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Jan 2019
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
December 25, 2018
CompletedFirst Posted
Study publicly available on registry
December 28, 2018
CompletedStudy Start
First participant enrolled
January 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2020
CompletedDecember 28, 2018
December 1, 2018
1 year
December 25, 2018
December 25, 2018
Conditions
Outcome Measures
Primary Outcomes (1)
level of serum mitochondrial DNA
level of serum mitochondrial DNA in severe acute pancreatitis
baseline
Interventions
serum mitochondrial DNA will be measured using RT-PCR within first 72 hours of symptoms of acute pancreatitis
Eligibility Criteria
Patients will be enrolled from Raghi hospital ,Assiut university who will be diagnosed with acute pancreatitis
You may qualify if:
- all patients diagnosed as acute pancreatitis using elevated serum amylase and contrast enhanced CT scan.
You may not qualify if:
- Alchoholics
- Renal impairment
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (1)
Wu L, Xu W, Wang F, Lv T, Yin Z, Song Y. Plasma mtDNA Analysis Aids in Predicting Pancreatic Necrosis in Acute Pancreatitis Patients: A Pilot Study. Dig Dis Sci. 2018 Nov;63(11):2975-2982. doi: 10.1007/s10620-018-5227-9. Epub 2018 Aug 9.
PMID: 30094625BACKGROUND
Biospecimen
Mitochondrial dna serum using qt\_PCR
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- spechialist
Study Record Dates
First Submitted
December 25, 2018
First Posted
December 28, 2018
Study Start
January 1, 2019
Primary Completion
January 1, 2020
Study Completion
December 1, 2020
Last Updated
December 28, 2018
Record last verified: 2018-12