Epicardial Adipose Tissue Thickness PredIcts Obstructive Coronary Artery Disease in Acute Coronary Syndrome Patients

NCT03787797 | Completed

• 1 other identifier: 18-8402-BO
• Study Type: observational
• Target: 657
• Locations: 1 country
• Sites: 1

Brief Summary

Epicardial adipose tissue (EAT) is a visceral adipose tissue that surrounds the heart and the coronary arteries. It is metabolically active, secreting pro- and anti-inflammatory mediators and cytokines. With increasing EAT volume, inflammatory activity increasing, which suggests that EAT may locally influence atherosclerosis development in the coronary artery tree. The amount of EAT is associated with cardiovascular disease risk factors as well as presence and progression of subclinical atherosclerosis. Likewise, EAT volume is increased in patient with prevalent and incident coronary artery disease manifestation. In the setting of acute coronary syndrome, EAT was found to be associated with the TIMI risk score and Syntax II score. While CT imaging of the heart is the gold standard for EAT quantification, transthoracic echocardiography allows for a quick and reliable assessment of EAT thickness, as has been used in research studies and may qualify for routine EAT assessment in clinical routine.However, currently data on how quantification of EAT in clinical routine may impact patient management is lacking. We aim to investigate, whether quantification of EAT thickness via transthoracic echocardiography enables improved risk stratification in patients presenting with acute chest pain to the emergency department.

Conditions

Acute Coronary Syndrome

Keywords

Epicardial adipose tissue; Chest pain; Echocardiography; Coronary artery disease

Outcome Measures

Primary Outcomes (1)

• Coronary revascularization

  Number of Participants with need for coronary revascularization therapy

  within 90 days after initial presentation

Secondary Outcomes (1)

• Invasive coronary angiography

  within 90 days after initial presentation

Interventions

Echocardiography DIAGNOSTIC_TEST

Assessment of epicardial adipose tissue thickness

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Inclusion of patients without known coronary artery disease undergoing workup for suspected acute coronary syndrome at the emergency department of the University Hospital Essen.

You may qualify if:

• admission to the emergency department of the University Hospital Essen with acute chest pain suggestive of an acute coronary syndrome

You may not qualify if:

• Known obstructive coronary artery disease prior to presentation, prior revascularization therapy, unwillingness to provide informed consent

Sponsors & Collaborators

• University Hospital, Essen: lead

Study Sites (1)

University Hospital Essen

Essen, North Rhine-Westphalia, 4, Germany

Location

Related Publications (1)

• Roggel A, Jehn S, Dykun I, Balcer B, Al-Rashid F, Totzeck M, Risse J, Kill C, Rassaf T, Mahabadi A. Regional wall motion abnormalities on focused transthoracic echocardiography in patients presenting with acute chest pain: a predefined post hoc analysis of the prospective single-centre observational EPIC-ACS study. BMJ Open. 2024 Sep 10;14(9):e085677. doi: 10.1136/bmjopen-2024-085677.

  PMID: 39260858 DERIVED

MeSH Terms

Conditions

Acute Coronary Syndrome; Chest Pain; Coronary Artery Disease

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Coronary Disease; Arteriosclerosis; Arterial Occlusive Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Study Officials

• Amir A Mahabadi, MD

  University Hospital, Essen

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 21, 2018
• First Posted: December 26, 2018
• Study Start: December 6, 2018
• Primary Completion: December 14, 2020
• Study Completion: August 30, 2022
• Last Updated: November 3, 2022

Record last verified: 2022-11

Data Sharing

• IPD Sharing: Will share

Locations

DE (1)