Preserving Left Colonic Artery During Radical Resection of Rectal Cancer

NCT03776370 | Completed DMC

• 1 other identifier: 20181155
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 2

Brief Summary

To evaluate the feasibility and clinical significance of preserving left colonic artery in rectal cancer surgery.The investigators will focus on the effect of preserving left colonic artery during radical resection of rectal cancer on anastomotic leakage and oncology efficacy.

Conditions

Postoperative Complications; Proteinosis

Keywords

rectal cancer; Postoperative Complications; Preserve the left colonic artery

Outcome Measures

Primary Outcomes (4)

• The incidence of postoperative anastomotic leakage was compared between the two groups.

  The incidence of anastomotic leakage within 30 days after surgery was compared between the intervention group and the control group.

  Within 30 days after surgery

• The distant metastasis rates of rectal cancer between the two groups were compared.

  The incidence of distant metastasis rectal cancer within two years after surgery was compared between the intervention group and the control group.

  Two years after surgery

• The local recurrence rates of rectal cancer between the two groups were compared.

  The incidence of local recurrence rectal cancer within two years after surgery was compared between the intervention group and the control group.

  Two years after surgery

• The five-year survival rates of rectal cancer between the two groups were compared.

  The 5-year survival rates of rectal cancer in the intervention group and the control group were compared.

  Five years after surgery

Study Arms (2)

Preserve the left colonic artery

Preservation of left colonic artery in rectal cancer surgery.

Procedure: Preserve the left colonic artery

The left colonic artery is not preserved

The left colonic artery was dissected in rectal cancer surgery

Procedure: The left colonic artery is not preserved

Interventions

Preserve the left colonic artery PROCEDURE

Preservation of left colonic artery in rectal cancer surgery.

Preserve the left colonic artery

The left colonic artery is not preserved PROCEDURE

The left colonic artery was dissected in rectal cancer surgery.

The left colonic artery is not preserved

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who underwent laparoscopic or robotic anterior rectal resections carried out by two surgeons at Daping Hospital.

You may qualify if:

• Pathological biopsy confirmed adenocarcinoma of the rectum；
• Preoperative assessment of tolerance to surgery without major organ dysfunction；
• Patients must be able to understand and voluntarily sign written informed consent；
• The surgical method is laparoscopic or robotic anterior rectal cancer resection.

You may not qualify if:

• The patient cannot tolerate the operation；
• Refusal to sign informed consent；
• Patients with distant metastasis of rectal cancer；
• The surgical method was changed to miles or Hartman;
• Unable to complete the follow - up

Sponsors & Collaborators

• Third Military Medical University: lead

Study Sites (2)

zongming,Kang

Chongqing, Chongqing Municipality, 400000, China

Location

zongming,Kang

Yuzhong, Chongqing Municipality, 400000, China

Location

Related Publications (3)

• Fan YC, Ning FL, Zhang CD, Dai DQ. Preservation versus non-preservation of left colic artery in sigmoid and rectal cancer surgery: A meta-analysis. Int J Surg. 2018 Apr;52:269-277. doi: 10.1016/j.ijsu.2018.02.054. Epub 2018 Mar 1.

  PMID: 29501795 RESULT

• Sekimoto M, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Doki Y, Mori M. Laparoscopic lymph node dissection around the inferior mesenteric artery with preservation of the left colic artery. Surg Endosc. 2011 Mar;25(3):861-6. doi: 10.1007/s00464-010-1284-7. Epub 2010 Aug 20.

  PMID: 20725744 RESULT

• Zheng H, Li F, Xie X, Zhao S, Huang B, Tong W. Preservation versus nonpreservation of the left colic artery in anterior resection for rectal cancer: a propensity score-matched analysis. BMC Surg. 2022 May 10;22(1):164. doi: 10.1186/s12893-022-01614-y.

  PMID: 35538516 DERIVED

MeSH Terms

Conditions

Postoperative Complications; Rectal Neoplasms

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Intestinal Diseases; Rectal Diseases

Study Officials

• Wei d tong, PhD

  Army Military Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Professor

Study Record Dates

• First Submitted: December 9, 2018
• First Posted: December 14, 2018
• Study Start: December 1, 2018
• Primary Completion: January 1, 2022
• Study Completion: January 1, 2022
• Last Updated: May 4, 2022

Record last verified: 2022-04

Data Sharing

• IPD Sharing: Will not share

Locations

CN (2)