NCT03770507

Brief Summary

The purpose of this research study is to understand how different kinds of exercise affect the human body and the health of the heart and lungs.Participants will exercise in different protocols on a bicycle ergometer or treadmill. This research could lead to improved and more accurate fitness assessment and pave the way to an improved personalized exercise program in health and illness.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
94

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Apr 2016

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 26, 2016

Completed
7 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2016

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2016

Completed
1.9 years until next milestone

First Submitted

Initial submission to the registry

November 8, 2018

Completed
1 month until next milestone

First Posted

Study publicly available on registry

December 10, 2018

Completed
7.3 years until next milestone

Results Posted

Study results publicly available

March 23, 2026

Completed
Last Updated

March 23, 2026

Status Verified

July 1, 2025

Enrollment Period

7 months

First QC Date

November 8, 2018

Results QC Date

February 15, 2024

Last Update Submit

March 19, 2026

Conditions

Methods of Exercise in Children

Outcome Measures

Primary Outcomes (1)

  • Maximum Oxygen Uptake (VO2) Measurements During Exercise

    Breath by breath gas exchange VO2 in response to exercise.

    At least 48 hours

Secondary Outcomes (1)

  • Heart Rate (HR) Measurements During Exercise

    At least 48 hours

Study Arms (6)

Cyclo Ergometer Exercise in Children

EXPERIMENTAL

Comparison of gas exchange kinetics and heart rate in cyclo ergometer exercises among children

Other: Exercise Training

Treadmill Exercise in Children

EXPERIMENTAL

Comparison of gas exchange kinetics and heart rate in treadmill exercises among children

Other: Exercise Training

Cyclo Ergometer Exercise in Adolescents

EXPERIMENTAL

Comparison of gas exchange kinetics and heart rate in cyclo ergometer exercises among adolescents

Other: Exercise Training

Treadmill Exercise in Adolescents

EXPERIMENTAL

Comparison of gas exchange kinetics and heart rate in treadmill exercises among adolescents

Other: Exercise Training

Cyclo Ergometer Exercise in Adults

EXPERIMENTAL

Comparison of gas exchange kinetics and heart rate in cyclo ergometer exercises among adults

Other: Exercise Training

Treadmill Exercise in Adults

EXPERIMENTAL

Comparison of gas exchange kinetics and heart rate in treadmill exercises among adults

Other: Exercise Training

Interventions

Exercise TrainingOTHER

Comparison of stationary bike and treadmill exercise among children, adolescents and adults

Cyclo Ergometer Exercise in AdolescentsCyclo Ergometer Exercise in AdultsCyclo Ergometer Exercise in ChildrenTreadmill Exercise in AdolescentsTreadmill Exercise in AdultsTreadmill Exercise in Children

Eligibility Criteria

Age7 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Between the ages of 7-35 years old without any known respiratory, cardiac or metabolic disease
  • Determined to be in good health by preparticipation history
  • No evidence of disease or disability that would impair participation in an exercise testing
  • No chronic prescribed medication

You may not qualify if:

  • Other limitation which in the eyes of the physician that would preclude ability to perform exercise testing
  • Use of illegal drugs or abuse of alcohol
  • Pregnancy or breastfeeding

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Pediatric Exercise and Genomics Research Center, University of California, Irvine

Irvine, California, 92697/92617, United States

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Limitations and Caveats

The same order of exercise test modalities may influence the second test session. Supramaximal test was not performed.

Results Point of Contact

Title
Dr. Peter Horvath (Administrative Contact)
Organization
University of California, Irvine
phorvath@hs.uci.edu
(714) 456-8248

Publication Agreements

PI is Sponsor Employee
No
Restrictive Agreement
No

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

November 8, 2018

First Posted

December 10, 2018

Study Start

April 26, 2016

Primary Completion

December 1, 2016

Study Completion

December 1, 2016

Last Updated

March 23, 2026

Results First Posted

March 23, 2026

Record last verified: 2025-07

Locations

US(1)