The Effect of 10-Week Exercise Training on Children With Asthma

NCT03716219 | Withdrawn

• 1 other identifier: 2012-9253
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this research is to determine whether 10-weeks of exercise training can benefit asthmatic children and young adults with a history of exercise-induced bronchoconstriction (EIB). The investigators will also study an exciting newly discovered aspect of gene expression regulation in the white blood cells known as epigenetics: a process that takes place when genomic changes happen as a result of exposure to the environment. This study is based on emerging exciting new data from this and other laboratories demonstrating that (a) white blood cells play an important role in bronchoconstriction in children, (b) gene and cytokine expression in circulating white blood cells are abnormal in asthma and (c) brief exercise may change genomic and inflammatory- profiles of these cells.Physical activity is an essential component of growth and health in children, thus, this research will lead to improved clinical uses of exercise as preventive and adjunctive therapy in the current epidemic of childhood asthma

Conditions

Asthma in Children

Outcome Measures

Primary Outcomes (1)

• Gene and microRNA expression will be compared between healthy and asthmatic subjects

  Monocyte gene expression profiling before and after acute bout of exercise before and after 10-week exercise intervention is gauged using RNA seq in a group of children with asthma and age and sex match healthy controls

  12 weeks

Secondary Outcomes (1)

• Pro/anti-inflammatory cytokines and markers of oxidative stress will be compared between the groups

  12 weeks

Study Arms (2)

Healthy Subjects

OTHER

Healthy control group which received the same exercise training intervention as the experimental group

Other: Exercise Training

Subjects with Asthma

EXPERIMENTAL

Subjects with asthma who received exercise training

Other: Exercise Training

Interventions

Exercise Training OTHER

Physical activity in children and adults with asthma.

Healthy Subjects; Subjects with Asthma

Eligibility Criteria

• Age: 8 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)

You may qualify if:

• Good health
• Physical activity
• No evidence of disease or disability
• Diagnosed with persistent asthma (asthma subjects)
• BMI\<95 percentile

You may not qualify if:

• Use of illegal drugs or alcohol
• Very high physical fitness
• Pregnancy
• More than two asthma attack per week (asthma subjects)

Sponsors & Collaborators

• University of California, Irvine: lead

Study Sites (1)

Pediatric Exercise and Genomics Research Center, University of California, Irvine

Irvine, California, 92697/92617, United States

Location

Related Publications (7)

• Drews AC, Pizzichini MM, Pizzichini E, Pereira MU, Pitrez PM, Jones MH, Sly PD, Stein RT. Neutrophilic airway inflammation is a main feature of induced sputum in nonatopic asthmatic children. Allergy. 2009 Nov;64(11):1597-601. doi: 10.1111/j.1398-9995.2009.02057.x. Epub 2009 Apr 14.

  PMID: 19392986 BACKGROUND

• Dougherty RH, Fahy JV. Acute exacerbations of asthma: epidemiology, biology and the exacerbation-prone phenotype. Clin Exp Allergy. 2009 Feb;39(2):193-202. doi: 10.1111/j.1365-2222.2008.03157.x.

  PMID: 19187331 BACKGROUND

• Baines KJ, Simpson JL, Scott RJ, Gibson PG. Immune responses of airway neutrophils are impaired in asthma. Exp Lung Res. 2009 Sep;35(7):554-69. doi: 10.1080/01902140902777490.

  PMID: 19842845 BACKGROUND

• Baines KJ, Simpson JL, Bowden NA, Scott RJ, Gibson PG. Differential gene expression and cytokine production from neutrophils in asthma phenotypes. Eur Respir J. 2010 Mar;35(3):522-31. doi: 10.1183/09031936.00027409. Epub 2009 Sep 24.

  PMID: 19797135 BACKGROUND

• Radom-Aizik S, Zaldivar F Jr, Oliver S, Galassetti P, Cooper DM. Evidence for microRNA involvement in exercise-associated neutrophil gene expression changes. J Appl Physiol (1985). 2010 Jul;109(1):252-61. doi: 10.1152/japplphysiol.01291.2009. Epub 2010 Jan 28.

  PMID: 20110541 BACKGROUND

• Cooper DM, Radom-Aizik S, Schwindt C, Zaldivar F Jr. Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity. J Appl Physiol (1985). 2007 Aug;103(2):700-9. doi: 10.1152/japplphysiol.00225.2007. Epub 2007 May 10.

  PMID: 17495117 BACKGROUND

• Petersen AM, Pedersen BK. The role of IL-6 in mediating the anti-inflammatory effects of exercise. J Physiol Pharmacol. 2006 Nov;57 Suppl 10:43-51.

  PMID: 17242490 BACKGROUND

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 3, 2018
• First Posted: October 23, 2018
• Study Start: October 10, 2013
• Primary Completion: October 10, 2013
• Study Completion: October 10, 2013
• Last Updated: February 12, 2021

Record last verified: 2021-02

Locations

US (1)