Characterization of the Genetic Profile of Type 2 Endometrial Carcinoma in Martinique

NCT03766672 | Completed

• 2 other identifiers: 18_RIPH2_152018-A02091-54
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

In Martinique, about 33 new cases are diagnosed per year, with a high incidence rate of type 2 endometrial carcinoma which has a poor prognosis with few therapeutic options. Although targeted therapies are used in many types of cancer, they are still possible a minority of patients. In current practice, endometrial cancers do not benefit these therapies. Characterization of the molecular mechanisms involved in the genesis of type 2 endometrial carcinoma could help to identify biomarkers predictive of a response to targeted therapies. We propose to identify the genetic profile of type 2 endometrial carcinomas in Martinique.

Conditions

Endometrial Neoplasms

Keywords

Endometrial carcinoma

Outcome Measures

Primary Outcomes (1)

• Number of biomarkers identified by Next Generation Sequencing involved in type 2 endometrial tumors in Martinique

  Characterization of potentially operable mutations in type 2 endometrial tumors from DNA sample withdraw at inclusion and during follow visit

  24 Months

Study Arms (1)

Intervention Arm

Identify the genetic profile of type 2 endometrial carcinomas in Martinique from tumor sample for extraction of tumor DNA .

Diagnostic Test: Intervention Arm

Interventions

Intervention Arm DIAGNOSTIC_TEST

The intervention consists to the characterization of molecular mechanisms using to Next Generation Sequencing (NGS) technique.

Intervention Arm

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Women aged more 18 years living in Martinique with a type 2 endometrial cancer confrimed by with anatomopathological reports.

You may qualify if:

• Major subject living in Martinique with the following characteristics :
• Patients with type 2 endometrial cancer, with anatomopathological confirmation
• Affiliate or beneficiary of french social security.

You may not qualify if:

• Type 1 adenocarcinoma
• Patients not affiliated to french social security
• Refusal to participate.

Sponsors & Collaborators

• University Hospital Center of Martinique: lead
• Martinique Cancer Registry: collaborator

Study Sites (1)

Chu Martinique

Fort-de-France, Martinique

Location

Biospecimen

Retention: SAMPLES WITH DNA

Samples for extraction of DNA on whole blood

MeSH Terms

Conditions

Endometrial Neoplasms

Condition Hierarchy (Ancestors)

Uterine Neoplasms; Genital Neoplasms, Female; Urogenital Neoplasms; Neoplasms by Site; Neoplasms; Uterine Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Diseases

Study Officials

• Medhi JEAN-LAURENT, MD

  CHU Martinique

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 30, 2018
• First Posted: December 6, 2018
• Study Start: November 22, 2019
• Primary Completion: November 22, 2021
• Study Completion: July 22, 2024
• Last Updated: August 21, 2024

Record last verified: 2024-08

Data Sharing

• IPD Sharing: Will not share

Locations

MA (1)