NCT03763305|Withdrawn
Study Stopped
Devices for measuring SKNA are need to be re-constructed, which takes considerable time.
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Sponsor study identifier
interventional
0
0 countries
N/A
Study Start
January 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Primary Completion
December 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Skin sympathetic nerve activity (SKNA) has recently been discovered from the electrocardiogram obtained from healthy volunteers. The raw physiologic electric signal from electrodes placed on the skin was reprocessed through filtering and integration using software to produce the SKNA signal. However, no study has yet provided knowledge on the effect of anesthetics on SKNA during general anesthesia.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 25, 2018
Actual (reported)December 4, 2018
Actual (reported)January 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
December 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
The skin sympathetic nerve activity (SKNA) presented as uV obtained via skin leads.
The average intraoperative SKNA divided by average SKNA before induction of general anesthesia (T0)
Intraoperative
Percent change of SKNA
T1: 1.5 minute after use of anesthetics, T2: 1.5 minute after use of muscle relaxant, T3: 30 seconds after intubation, T4: before bladder expansion, T5: 30 seconds after bladder expansion, T6: 30 sec after start of surgery, T7: 30sec after end of surgery
Study participants are anesthetized by total intravenous anesthesia (TIVA) using propofol continuous infusion and remifentanil continuous infusion. During induction of general anesthesia, participants receive 3\~5mcg/mL Propofol Fresenius and 3\~5ng/mL and Remifentanil \[Ultiva\] as initial effect site concentrations. The effect site concentration is controlled with target-controlled infusion to maintain bispectral index (BIS) values between 40 and 60.
Study participants receive fentanyl 1mcg/kg and propofol bolus injection 1.5\~2mg/kg for induction of general anesthesia. For maintenance of anesthesia, sevoflurane inhalant solution \[Sojourn\] is used to maintain 1 age-related minimum alveolar concentration (MAC).
Propofol intravenous continuous infusion for anesthetic induction and maintenance
Remifentanil intravenous continuous infusion for anesthetic induction and maintenance
These entries preserve how the registry describes the intervention. Their treatment roles are shown separately from molecular identities.
Administration procedure
Propofol continuous infusion
The registry describes an administration procedure or treatment schedule. Actual exposure and doses are not established by this entry.
View registry recordAdministration procedure
Propofol bolus injection
The registry describes an administration procedure or treatment schedule. Actual exposure and doses are not established by this entry.
View registry recordYunseok Jeon, MD, PhD
Seoul National University Hospital
0 participants (actual enrollment reported by the registry).
First Submitted
November 25, 2018
First Posted
December 4, 2018
Study Start
January 1, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Comparison of Desflurane, Sevoflurane, and Total Intravenous Anesthesia in Ear Surgery Under Controlled Hypotension
Study participants receive fentanyl 1mcg/kg and propofol bolus injection 1.5\~2mg/kg for induction of general anesthesia. For maintenance of anesthesia, desflurane \[Suprane\] is used to maintain 1 age-related minimum alveolar concentration (MAC).
Study participants receive fentanyl 1mcg/kg and propofol 1.5\~2mg/kg for induction of general anesthesia. For maintenance of anesthesia, desflurane is used to maintain 1 age-related minimum alveolar concentration (MAC).
1 age-related minimum alveolar concentration (MAC) of desflurane inhalation for anesthetic maintenance
Propofol intravenous injection for anesthetic induction
Contact the study team to confirm eligibility.
Primary Completion
December 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Study Completion
December 31, 2023
Estimated (date passed)This estimate has passed. The registry has not confirmed an actual date for this milestone.
Last Updated
May 11, 2022
Record last verified: 2022-05
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