NCT07399223

Brief Summary

Analytical techniques used in metabolomic studies include nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). The study will involve comparing the metabolomic profiles of patients receiving sevoflurane and desflurane during surgery to identify any differences in metabolic pathways affected by the two anaesthetic techniques. Metabolomic profiles are generated using spectroscopic and spectrometric techniques such as high-field NMR and MS, as well as separation techniques.

Trial Health

65
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
80

participants targeted

Target at P50-P75 for not_applicable

Timeline
0mo left

Started Feb 2026

Shorter than P25 for not_applicable

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress94%
Feb 2026May 2026

First Submitted

Initial submission to the registry

January 5, 2026

Completed
27 days until next milestone

Study Start

First participant enrolled

February 1, 2026

Completed
9 days until next milestone

First Posted

Study publicly available on registry

February 10, 2026

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 15, 2026

Completed
15 days until next milestone

Study Completion

Last participant's last visit for all outcomes

May 30, 2026

Expected
Last Updated

February 23, 2026

Status Verified

February 1, 2026

Enrollment Period

3 months

First QC Date

January 5, 2026

Last Update Submit

February 20, 2026

Conditions

Sevoflurane DesfluraneMetabolomic Effect

Outcome Measures

Primary Outcomes (2)

  • amino acid metabolism

    12 weeks

  • Our primary outcome measure will be the effect of both inhalation anaesthetics on amino acid metabolism.

    12 weeks

Study Arms (2)

sevoflurane group

ACTIVE COMPARATOR
Procedure: Sevoflurane

desflurane group

ACTIVE COMPARATOR
Procedure: Desflurane

Interventions

SevofluranePROCEDURE

This group will be operated on under sevoflurane.

sevoflurane group
DesfluranePROCEDURE

This group will be operated on under desflurane.

desflurane group

Eligibility Criteria

Age18 Years - 65 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Patients undergoing laparoscopic cholecystectomy surgery who have no active infection, Body mass index (BMI)\<35, Aged 18-65, ASA I-II, and who agree to participate in the study

You may not qualify if:

  • Individuals over 65 years of age ASA 3-4 patients Individuals with a body mass index (BMI) \>35 Smokers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

MeSH Terms

Interventions

SevofluraneDesflurane

Intervention Hierarchy (Ancestors)

Methyl EthersEthersOrganic ChemicalsHydrocarbons, FluorinatedHydrocarbons, HalogenatedHydrocarbonsEthyl Ethers

Central Study Contacts

Ahmet Atlas

CONTACT

+905322524176ahmetatlas@harran.edu.tr

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
associate professor

Study Record Dates

First Submitted

January 5, 2026

First Posted

February 10, 2026

Study Start

February 1, 2026

Primary Completion

May 15, 2026

Study Completion (Estimated)

May 30, 2026

Last Updated

February 23, 2026

Record last verified: 2026-02

Data Sharing

IPD Sharing
Will not share