Does the Embryo Transfer Technique Affect the Success of in Vitro Fertilization?

NCT03756857 | Unknown

• 1 other identifier: AcibademKD
• Study Type: interventional
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

Prospective, open, randomized, parallel, two-arm trial to compare the clinical pregnancy rate between most commonly used two embryo transfer techniques: trial followed by transfer technique and afterloading technique

Conditions

Infertility; Assisted Reproductive Technology; IVF

Outcome Measures

Primary Outcomes (1)

• clinical pregnancy rate

  the presence of gestational sac on ultrasound

  5-6 weeks after embryo transfer

Secondary Outcomes (1)

• implantation rate

  3-4 weeks after embryo transfer

Study Arms (2)

Afterload transfer

EXPERIMENTAL

First, an empty catheter passes to the level of the lower uterine segment under ultrasound guidance to a point where the inner catheter enters the endometrial cavity. The inner sheath is removed slowly, leaving the outer sheath just beyond the internal os. After verifying the catheter's position on the TA ultrasound scan, the physician gives the signal to the embryologist to start the embryo loading. The embryologist brings the loaded inner catheter and inserts it into the outer sheath, which is maintained in its position by the physician.

Procedure: Afterload Transfer

Trial Followed by Transfer

EXPERIMENTAL

First a trial transfer is performed using both the inner catheter and outer sheath connected together in standard configuration, just before the actual embryo transfer. It is passed up to and just through the the internal os. When it appears that the actual transfer will be possible without great difficulty ,the trial catheter is withdrawn. An embryo transfer catheter is loaded and the actual transfer is performed

Procedure: Trial followed by transfer

Interventions

Afterload Transfer PROCEDURE

Embryo transfer is done by using "afterload transfer" method

Afterload transfer

Trial followed by transfer PROCEDURE

Embryo transfer is done by using "afterload transfer" method

Trial Followed by Transfer

Eligibility Criteria

• Age: 20 Years - 37 Years
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patient has given written informed consent
• BMI 18-30 kg/m2
• \< 2 previous failed IVF trials
• At least two good quality embryos on the day of transfer

You may not qualify if:

• Congenital uterine anomaly
• Untreated endometrial polyp or fibroid distorting uterine cavity
• Presence of hydrosalpinx 4.2 or more prior IVF trial failure
• Moderate to severe endometriosis 6.Recurrent pregnancy loss history

Sponsors & Collaborators

• Acibadem Kadiköy Hospital: lead

Study Sites (1)

Acibadem Altunizade Hospital, Unit of ART

Istanbul, 34662, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Infertility

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Central Study Contacts

Elif Esra UYAR, MD

CONTACT

+902166494444; esra.uyar@acibadem.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medical Doctor

Model Details: Prospective, open, randomized, parallel, two-arm trial

Study Record Dates

• First Submitted: November 27, 2018
• First Posted: November 28, 2018
• Study Start: January 21, 2019
• Primary Completion: September 1, 2021
• Study Completion: December 1, 2021
• Last Updated: March 23, 2021

Record last verified: 2021-03

Locations

TU (1)