Effects of Supervised Exercise on Physical Health and Quality of Life Among Older HIV Adults

NCT03748797 | Completed

• 1 other identifier: supervised exercise
• Study Type: interventional
• Target: 21
• Locations: 1 country
• Sites: 1

Brief Summary

The effects of exercise for older HIV-infected adults have not been well studied, especially in Chinese population. This study aimed to investigate the effect of supervised exercise on physical health and quality of life among older people living with HIV (PLWH) in Hong Kong. HIV-infected adults were recruited from a community-based Non-Governmental Organization (NGO) for HIV patient services. Participants were randomized into exercise group or control group. The participants in exercise group performed an 8-week moderate intensity supervised exercise program. In the control group, participants were not given any supervised exercises. They were advised to continue their routine daily activities and self exercises. Outcomes were measured for both groups at baseline and after 8 weeks. Primary outcomes: grip strength, 30 seconds chair stand, 6 minutes-walk test and Short Form-36 questionnaire (SF-36). Secondary outcome: Subjective improvement At the end of the program, all participants from exercise group were interviewed individually by principle investigator to allow feedbacks.

Conditions

HIV/AIDS

Keywords

HIV, exercise, aging, physical health, quality of life

Outcome Measures

Primary Outcomes (4)

• Change of SF-36 scores

  Short Form 36 (SF-36) questionnaire is used to assess health related quality of life

  Change from Baseline SF-36 scores at 8 weeks

• Change of Grip strength

  Maximum grip strength of the participant in kg

  Change from Baseline grip strength at 8 weeks

• Change of 30 seconds chair stand

  Number of times that the participant stand up and sit down within 30 seconds

  Change from Baseline performance at 8 weeks

• Change of 6 minutes walk test

  The distance (in meters) which the participant is able to walk in 6 minutes

  Change from Baseline performance at 8 weeks

Secondary Outcomes (1)

• Subjective improvement

  Subjective change after 8 weeks compare to baseline

Study Arms (2)

Exercise group

EXPERIMENTAL

8-week moderate intensity exercise training under supervision

Other: Moderate intensity exercise training under supervision

Control group

NO INTERVENTION

No supervised exercise training given. Participants were advised to continue their routine daily activities and self exercises if they have

Interventions

Moderate intensity exercise training under supervision OTHER

Upper and lower limbs cycling, treadmill walking, multi-gym strengthening, stepper exercise, dumb bell and squatting exercise

Exercise group

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Participants with HIV age \> 50, treating with antiretroviral therapy
• No contraindication to moderate intensity exercise
• Independent Outdoor walker without assistance
• Sedentry participants who have not received any structural / supervised exercise program in the past 1 year

You may not qualify if:

• Age \<50
• Unstable or unfit for exercise
• Wheelchair user or assisted walker
• Already had regular exercise habit or under structural exercise program in the past 1 year

Sponsors & Collaborators

• The Society for AIDS Care: lead
• The University of Hong Kong: collaborator

Study Sites (1)

The Society for AIDS Care Day Centre

Hong Kong, Hong Kong

Location

MeSH Terms

Conditions

Acquired Immunodeficiency Syndrome; Motor Activity

Condition Hierarchy (Ancestors)

HIV Infections; Blood-Borne Infections; Communicable Diseases; Infections; Sexually Transmitted Diseases, Viral; Sexually Transmitted Diseases; Lentivirus Infections; Retroviridae Infections; RNA Virus Infections; Virus Diseases; Slow Virus Diseases; Genital Diseases; Urogenital Diseases; Immunologic Deficiency Syndromes; Immune System Diseases; Behavior

Study Officials

• Chi Hong Chung, MSc

  The Society for AIDS Care

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: A research assistant who was blinded for the participants grouping was responsible for data collection.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Physiotherapist

Model Details: Exercise group: Performed an 8-week, 2 times/week exercise training (moderate intensity) under physiotherapist supervision. Control group: No supervised exercise training given. Participants were advised to continue their routine daily activities and self exercises if they have.

Study Record Dates

• First Submitted: November 16, 2018
• First Posted: November 21, 2018
• Study Start: November 1, 2017
• Primary Completion: March 31, 2018
• Study Completion: March 31, 2018
• Last Updated: November 23, 2018

Record last verified: 2018-11

Locations

HK (1)