Sleep Subtypes in Adolescent Depression

NCT03742960 | Completed

• 1 other identifier: Sleep Subtypes
• Study Type: interventional
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to compare sleep neurophysiology and behavior in adolescents with MDD with hypersomnia (MDD-HYP) and insomnia (MDD-INS) with healthy controls (HC). In addition, the investigators will test the efficacy of a simple behavioral sleep restriction on mood and sleep in their sample.

Conditions

Major Depressive Disorder

Outcome Measures

Primary Outcomes (2)

• Change in self-reported sleep efficiency (defined as total sleep time divided by time in bed and thus expressed as a percentage) as assessed via sleep diary

  Changes in self-reported sleep efficiency will be measured via sleep diary. The data will be collected by ecological momentary assessment (EMA). Time in bed (TIB) is defined as the time between participants reporting going to bed and waking up. Total sleep time (TST) is defined as TIB minus the amount of time participants report taking to fall asleep (sleep onset latency; SOL) and the duration of waking after sleep onset (WASO).

  Two weeks

• Change in self-reported mood assessed via the Multidimensional Mood Questionnaire

  Changes in self-reported mood will be measured via ecological momentary assessment. Participants will fill out the Multidimensional Mood Questionnaire four times a day (morning, after school, at dusk and 30 minutes before bedtime). The Multidimensional Mood Questionnaire assesses the state "happy/sad" on a visual analog scale from 0 to 100. The mean across the day will be calculated.

  Two weeks

Secondary Outcomes (4)

• Change in Repetitive Negative Thinking (focus on problems) assessed by one question from the Response Style Questionnaire

  Two weeks

• Change in Repetitive Negative Thinking (focus on feelings) assessed by one question from the Response Style Questionnaire

  Two weeks

• Change in depressive symptoms from 1 to 3 days prior to the sleep manipulation and the end of the manipulation (second to last or last day of sleep manipulation)

  Two weeks

• Change in anxiety symptoms from 1 to 3 days prior to the sleep manipulation and the end of the manipulation (second to last or last day of sleep manipulation)

  Two weeks

Study Arms (1)

Behavioral Sleep Restriction

EXPERIMENTAL

Participants will be required to go to sleep half an hour later than their usual bedtime. Wake up time will be determined via their usual wake time.

Behavioral: Behavioral Sleep Restriction

Interventions

Behavioral Sleep Restriction BEHAVIORAL

Participants will be instructed to go to bed 30 minutes later than their usual bedtime. On the other hand, wake up time will be unchanged resulting a nightly sleep restriction of 30 minutes. This protocol will be followed for two weeks.

Behavioral Sleep Restriction

Eligibility Criteria

• Age: 14 Years - 17 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• \- This study will recruit adolescents (ages 14 to 17 years) with major depressive disorder (MDD) with insomnia (MDD-INS) and with hypersomnia (MDD-HYP) and age and gender matched controls (HC).
• MDD as determined through the MINI-KID
• Determination of hypersomnia as defined by excessive daytime sleepiness, or long sleep duration.
• Written informed consent
• MDD as determined through the MINI-KID
• Determination of insomnia as defined by the insomnia severity index
• Written informed consent

You may not qualify if:

• Current or lifetime experience of frank psychosis or mania
• Presence of suicidal intent representing imminent risk as indicated during clinical interview
• Medical or neurological condition that could impact brain functioning
• History of physical brain injury or blow to the head resulting in loss of consciousness greater than 5 minutes
• Do not meet criteria for substance or alcohol dependence in the last three months
• Presence of an organic sleep disorder (e.g., narcolepsy, sleep apnea)
• Presence of psychiatric disorder
• Self-reported disrupted, short or ill-timed sleep
• No sleep difficulties

Sponsors & Collaborators

• University of Bern: lead
• University Hospital for Child and Adolescent Psychiatry and Psychotherapy Bern: collaborator

Study Sites (1)

Leila Tarokh

Bern, 3000, Switzerland

Location

MeSH Terms

Conditions

Depressive Disorder, Major

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders

Study Officials

• Leila Tarokh, PhD

  Universitätsklinik für Kinder- und Jugendpsychiatrie und Psychotherapie

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 31, 2018
• First Posted: November 15, 2018
• Study Start: April 24, 2019
• Primary Completion: July 1, 2023
• Study Completion: July 1, 2023
• Last Updated: November 30, 2023

Record last verified: 2023-11

Locations

CH (1)