Effect of Dumbbell Exercise on Arteriovenous Fistula in Patients With Hemodialysis

NCT03741985 | Unknown

• 1 other identifier: GDREC2016329H
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Isometric exercise has been shown to increase the diameter and the blood flow rate of forearm veins.At present, more studies focus on the perioperative period to promote the maturation of arteriovenous fistula(AVF), while there are few reports on functional maintenance measures for the patients with maintenance hemodialysis.This study aims to explore the effect of dumbbell exercise on AVF，and evaluate whether patients can carry a 6-pound item with the fistula limb in a reasonable way.

Conditions

Arteriovenous Fistula

Outcome Measures

Primary Outcomes (1)

• Changes in blood flow of AVF draining vein

  The blood flow measurement was repeated three times at a location 5 cm proximal to the anastomosis in the draining vein by Doppler ultrasound.

  from Baseline to 3 months

Secondary Outcomes (5)

• Changes in diameter of AVF draining vein

  from Baseline to 3 months

• The ratio of pre-pump arterial pressure and blood flow

  from Baseline to 3 months

• Adverse event

  from Baseline to 3 months

• Changes in blood flow of AVF proximal artery

  from Baseline to 3 months

• Changes in blood flow of brachial artery

  from Baseline to 3 months

Study Arms (2)

The handgrip exercise

PLACEBO COMPARATOR

Patients are asked to squeeze a rubber ring 30 times per min for altogether 20 minutes on non-dialysis days.The 20-minute exercise can be divided into 3 parts according to individual circumstances.

Behavioral: The handgrip exercise

The dumbbell exercise

EXPERIMENTAL

Patients are asked to hold 6-pound dumbbells to exercise 30 times per min for altogether 20 minutes on non-dialysis days.The 20-minute exercise can be divided into 3 parts according to individual circumstances.

Behavioral: The dumbbell exercise

Interventions

The handgrip exercise BEHAVIORAL

The control group was given routine dialysis treatment and daily handgrip exercise .Patients are asked to squeeze a rubber ring 30 times per min for altogether 20 minutes on non-dialysis days.The 20-minute exercise can be divided into 3 parts according to individual circumstances.

The handgrip exercise

The dumbbell exercise BEHAVIORAL

The experimental group was given routine dialysis treatment and daily dumbbell exercise .Patients are asked to hold 6-pound dumbbells to exercise 30 times per min for altogether 20 minutes on non-dialysis days.The 20-minute exercise can be divided into 3 parts according to individual circumstances.

The dumbbell exercise

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients who have established arteriovenous fistula
• Patients whose muscle strength of the fistula limb is graded 4-5, which can overcome the 6-pound gravity and external resistance to complete the range of joint activity
• Patients who provided informed consent.

You may not qualify if:

• Left ventricular cardiac ejection fraction \<30%;
• Using a arteriovenous graft or a long-term catheter as a permanent access;
• The diameter of the aneurysm is greater than 2 cm or the aneurysm has a risk of rupture;
• Participation in other clinical trials at the same time;
• Severe cardiovascular diseases and other organ complications,malignant tumors, mental illnesses, etc.

Sponsors & Collaborators

• Guangdong Provincial People's Hospital: lead

Study Sites (1)

Guangdong General Hospital

Guangzhou, Guangdong, China

RECRUITING

Related Publications (1)

• Nantakool S, Reanpang T, Prasannarong M, Pongtam S, Rerkasem K. Upper limb exercise for arteriovenous fistula maturation in people requiring permanent haemodialysis access. Cochrane Database Syst Rev. 2022 Oct 3;10(10):CD013327. doi: 10.1002/14651858.CD013327.pub2.

  PMID: 36184076 DERIVED

MeSH Terms

Conditions

Arteriovenous Fistula

Condition Hierarchy (Ancestors)

Arteriovenous Malformations; Vascular Malformations; Cardiovascular Abnormalities; Cardiovascular Diseases; Vascular Fistula; Vascular Diseases; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Fistula; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 28, 2018
• First Posted: November 15, 2018
• Study Start: November 10, 2018
• Primary Completion: February 28, 2019
• Study Completion: February 28, 2019
• Last Updated: November 15, 2018

Record last verified: 2018-09

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)