NCT03726060

Brief Summary

The aim of study is evaluate the effectiveness of physical therapy in of the treatment myogenic temporomandibular disorders. They will enrolled 100 patient which will be divided into two groups. The primary objective is evaluate the effectiveness of physiotherapy on pain (measured with the Visual Analogic Scale - VAS scale). The second objective is evaluate mandibular motion (by measuring the range of motion - ROM) and investigate the presence of psychosocial factors (using the Anxiety and Depression Scale - HADS questionnaire).

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
62

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Oct 2018

Longer than P75 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

October 24, 2018

Completed
7 days until next milestone

First Posted

Study publicly available on registry

October 31, 2018

Completed
Same day until next milestone

Study Start

First participant enrolled

October 31, 2018

Completed
3.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 31, 2022

Completed
Last Updated

May 31, 2022

Status Verified

May 1, 2022

Enrollment Period

3.3 years

First QC Date

October 24, 2018

Last Update Submit

May 25, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Evaluate the effectiveness of physical therapy using the VAS scale which allows to measure the varation of pain

    The VAS measures the intensity of the pain that thethe patient perceived and it is represented by a 10 cm long scale with a score from 0 to 10. The VAS will be evaluated in 3 times: at rest; during the maximum buccal opening; during chewing

    Change from initial VAS at 3 and 6 months from the beginning of the treatment

Secondary Outcomes (1)

  • ROM (range of motion)

    The measurement of the ROM occurs at the recruitment then at 3 and 6 months from the beginning of the treatment

Study Arms (2)

splint therapy

OTHER

Alginate impressions will be taken and the plaster models of the dental arches will be made. The splint will be subsequently delivered to the patient with the relative indications of use. The splint therapy consist in the use of neuromuscoral splint every the night for 6 months.

Other: control group

physical therapy with splint therapy

OTHER

The treatment consists of a series of interventions: advice on self-treatment techniques to be performed at home and administering manual therapy techniques addressed to: temporomandibular district, cervical and cervico-thoracic junction. Each session will be carried out individually and will last for 45 minutes. This duration will be divided as follows: 25 minutes dedicated to the temporomandibular district, 15 minutes to the cervical and cervico-thoracic junction, 5 minutes to teaching self-treatment techniques to be carried out at home and to verify the correct way of performing them. The cycle will consist of 10 sessions distributed over 3 months.

Other: test group

Interventions

In the control group the patient will undergo gnathologic therapy for 6 months with neuromuscural splint every night for 3 months

Also known as: splint therapy
splint therapy

In the test group the patient will undergo gnathologic therapy with neuromuscural splint every night for 3 months in association with physical therapy

Also known as: splint therapy with physical therapy
physical therapy with splint therapy

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • patients with myogenic temporomandibular disorders assessed with clinical examination as established by the DC / TMD1;
  • patients older than 18 years;
  • good knowledge of Italian language;
  • patients who have signed informed consent

You may not qualify if:

  • edentulism which makes it impossible to apply gnathological bite;
  • patients with psychiatric problems;
  • patients included in other experimental protocols;
  • patients already undergoing surgical and / or radial therapy of the cervical and facial areas;
  • other temporomandibular disorders without a myogenic component;
  • treatment of the cervical and TMJ district in the previous 3 months;
  • history of drug abuse.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Bologna

Bologna, Emilia-Romagna, 40138, Italy

Location

Related Publications (2)

  • Romeo A, Incorvati C, Vanti C, Turolla A, Marinelli F, Defila L, Gulotta C, Marchetti C, Pillastrini P. Physical therapy in addition to occlusal splint in myogenic temporomandibular disorders: A randomised controlled trial. J Oral Rehabil. 2024 Aug;51(8):1566-1578. doi: 10.1111/joor.13729. Epub 2024 May 17.

  • Incorvati C, Romeo A, Fabrizi A, Defila L, Vanti C, Gatto MRA, Marchetti C, Pillastrini P. Effectiveness of physical therapy in addition to occlusal splint in myogenic temporomandibular disorders: protocol of a randomised controlled trial. BMJ Open. 2020 Aug 13;10(8):e038438. doi: 10.1136/bmjopen-2020-038438.

MeSH Terms

Conditions

Temporomandibular Joint Disorders

Interventions

Control GroupsPhysical Therapy Modalities

Condition Hierarchy (Ancestors)

Craniomandibular DisordersMandibular DiseasesJaw DiseasesMusculoskeletal DiseasesJoint DiseasesMuscular DiseasesStomatognathic Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Research DesignEpidemiologic MethodsInvestigative TechniquesResearch DesignMethodsTherapeuticsRehabilitation

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR INVESTIGATOR
PI Title
professor

Study Record Dates

First Submitted

October 24, 2018

First Posted

October 31, 2018

Study Start

October 31, 2018

Primary Completion

January 31, 2022

Study Completion

January 31, 2022

Last Updated

May 31, 2022

Record last verified: 2022-05

Data Sharing

IPD Sharing
Will not share

Locations