Investigation of Psychophysiological Correlation of Aggression and Response to Aversive Stimuli

NCT03725371 | Completed

• 1 other identifier: YNC-SASSI-Quanti-1
• Study Type: observational
• Target: 133
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study investigates the psychophysiological correlations of aggression and response to aversive stimuli in a population of 133 children clinically diagnosed with conduct disorder (CD) and/or attention-deficit/hyperactivity disorder (ADHD). Data was gathered about participants' level of aggression through the Reactive-Proactive Aggression Questionnaire (RPQ). The stimuli that were presented to the participants included 1) a loud sound, 2) threatening photographs from the International Affective Picture System (IAPS), and 3) the Trier Social Stress Task (TSST). Participants' psychophysiological features of heart rate and galvanic skin conductance were measured and analyzed in relation to their RPQ scores and clinical diagnosis.

Conditions

Conduct Disorder; ADHD; Oppositional Defiant Disorder

Outcome Measures

Primary Outcomes (3)

• Heart Rate

  For Trier Social Stress Task

  7 minutes

• Skin Conductance Response

  For loud sound

  4 minutes

• Skin Conductance Response

  For threatening photograph

  4 minutes

Interventions

No intervention was administered for the purpose of this study. OTHER

No intervention was administered for the purpose of this study. Observations were carried out for all participants.

Eligibility Criteria

• Age: 7 Years - 16 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

The study involves children and adolescents diagnosed with disruptive behaviour disorder (DBD, i.e. conduct disorder or oppositional defiant disorder) or attention deficit / hyperactivity disorder (ADHD, i.e. combined type or ADHD predominantly inattentive type or ADHD predominantly hyperactive-impulsive type).

You may qualify if:

• Subjects between ages 7 and 16 years
• Subjects who fulfil all criteria for a DSM-IV diagnosis of ADHD, conduct disorder, or oppositional defiant disorder
• Subjects with willingness to participate in a randomized, double-blind controlled trial
• Subjects with complete written, informed parental consent and child assent
• Subjects with IQ of 70 or more

You may not qualify if:

• Subjects who have IQ in the below 70
• Subjects who are younger than 7 years old or older than 16 years old
• Those without written parental consent
• Those with brain pathology such as serious head injury, epilepsy, etc.

Sponsors & Collaborators

• Yale-NUS College: lead

MeSH Terms

Conditions

Conduct Disorder; Attention Deficit Disorder with Hyperactivity; Oppositional Defiant Disorder

Condition Hierarchy (Ancestors)

Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Mental Disorders

Study Officials

• Daniel Fung

  Institute of Mental Health, Singapore

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor, Yale-NUS College and Adjunct Assistant Professor, Duke-NUS Graduate Medical School

Study Record Dates

• First Submitted: October 29, 2018
• First Posted: October 31, 2018
• Study Start: August 1, 2011
• Primary Completion: August 1, 2015
• Study Completion: August 1, 2015
• Last Updated: October 31, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share