Clinical and Suicidal Features of Urban, Turkish Middle Age Depressive Patients With Comorbid ADHD

NCT03721588 | Completed

• 1 other identifier: dresinerdogan
• Study Type: observational
• Target: 96
• Locations: 0 countries
• Sites: N/A

Brief Summary

In the presence of attention deficit hyperactivity disorder (ADHD) together with additional psychiatric diseases, the treatment process and prognosis of both ADHD and psychiatric comorbidity are adversely affected. The aim of this study is to compare the characteristics concerning the suicidal behavior of the patients with major depressive disorder (MDD) who have (ADHD+) or do not have (ADHD-) adult ADHD comorbidity and their responses to depression treatment. 96 inpatients were included in the study. Socio-demographic data form, Hamilton Depression Scale (HDRS), Wender Utah Rating Scale (WURS), Adult ADD/ADHD DSM IV- Based Diagnostic Screening and Rating Scale (A-ADHD), Personal and Social Performance Scale (PSP) were applied to the cases. In the study, depression starts at an early age in individuals with comorbid ADHD and the depression treatment progress changes negatively. This group of patients is at greater risk in terms of suicidal behavior. For these reasons, clinicians should be careful during ADHD and depression management in adults.

Conditions

Depressive Disorder, Major; Adult Attention Deficit Hyperactivity Disorder; Suicide

Outcome Measures

Primary Outcomes (1)

• depressive inpatients with comorbid ADHD (n=48) and without comorbid ADHD (n=48) were compared according to the suicidal behavior, the onset age of depression, the response to the treatment, and psychosocial functioning.

  Clinical interviews, psychometric scales such as, Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Hamilton Depression Rating Scale (HDRS), Adult ADD/ADHD DSM IV- Based Diagnostic Screening and Rating Scale (A-ADHDS), Wender Utah Rating Scale (WURS), Personal and Social Performance Scale (PSP) were applied. 96 inpatients were included in the study. In our study, depression starts at an early age in individuals with comorbid ADHD and the depression treatment progress changes negatively. This group of patients is at greater risk in terms of suicidal behavior.

  2 years

Study Arms (2)

Major depressive disorder

MDD; patients with diagnosis of major depressive disorder, Clinical interviews, psychometric scales were applied.

Other: Clinical interviews, psychometric scales were applied.

MDD and ADHD

MDD; major depressive disorder ADHD; attention deficit hyperactivity disorder, Clinical interviews, psychometric scales were applied.

Other: Clinical interviews, psychometric scales were applied.

Interventions

Clinical interviews, psychometric scales were applied. OTHER

MDD and ADHD; Major depressive disorder

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

inpatiets with diagnosis of major depressive disorder

You may qualify if:

• Complying with DSM-IV (Diagnostic and Statistical Manual of Mental Disorders, Fourth) criteria for major depression
• Hamilton Depression Scale (HDRS) being over 16 points during hospitalization

You may not qualify if:

• Mental retardation
• Psychotic disorder
• Alcohol or substance addiction
• History of head trauma
• Being under psychostimulant treatment

Sponsors & Collaborators

• Bozyaka Training and Research Hospital: lead

Related Publications (4)

• Duran S, Fistikci N, Keyvan A, Bilici M, Caliskan M. [ADHD in adult psychiatric outpatients: prevalence and comorbidity]. Turk Psikiyatri Derg. 2014 Summer;25(2):84-93. Turkish.

  PMID: 24936755 RESULT

• Agosti V, Chen Y, Levin FR. Does Attention Deficit Hyperactivity Disorder increase the risk of suicide attempts? J Affect Disord. 2011 Oct;133(3):595-9. doi: 10.1016/j.jad.2011.05.008. Epub 2011 Jun 11.

  PMID: 21658780 RESULT

• Tamam L, Demirkol ME. Adult attention deficit/hyperactivity disorder and mood disorders. Turkiye Klin J Psychiatry-Special Top 2012;5:48-3.

  RESULT

• Ekinci S, Öncü B, Canat S. Adult attention deficit hyperactivity disorder: comorbidity and functioning. Anadolu Psikiyatr Derg 2011;12:185-1.

  RESULT

MeSH Terms

Conditions

Depressive Disorder, Major; Attention Deficit Disorder with Hyperactivity; Suicide

Condition Hierarchy (Ancestors)

Depressive Disorder; Mood Disorders; Mental Disorders; Attention Deficit and Disruptive Behavior Disorders; Neurodevelopmental Disorders; Self-Injurious Behavior; Behavioral Symptoms; Behavior

Study Officials

• Esin Erdogan, MD

  Bozyaka Training and Research Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Psychiatry Department, MD

Study Record Dates

• First Submitted: October 12, 2018
• First Posted: October 26, 2018
• Study Start: September 1, 2015
• Primary Completion: June 1, 2017
• Study Completion: September 1, 2017
• Last Updated: October 30, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share