Trials Sponsors Conditions Drugs Pricing

Conditions

Quality of Life

Outcome Measures

Primary Outcomes (1)

HRQoL (Health Related Quality of Life)
To longitudinally and quantitatively describe the HRQoL of a diverse nation-wide cohort of sibling pediatric Hematopoietic Stem Cell (HSC) donors (Peripheral Blood Stem Cell or Bone Marrow) and to compare their HRQoL to that of (1) healthy non-donor sibling from the same family, (2) siblings of children with similar diseases who receive alternate treatments (e.g., unrelated cord blood transplants), and (3) healthy age, gender, and race/ethnicity-matched controls.
1 year

Secondary Outcomes (2)

1 year post-donation
1 year
Donor characteristics
1 year

Study Arms (6)

Sibling pediatric donors

Donors who are donating to a sibling

Sibling recipients and caregivers

Recipients who are receiving a transplant from a sibling

Non-donor sibling

From the donor-recipient families

Non-donor siblings

Of patients receiving unrelated transplants

Healthy comparison

A matched sample

Parents

Parent/caregiver of study participating donor.

Eligibility Criteria

Age5 Years+

Sexall

Healthy VolunteersYes

Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Pediatric donors, their recipients and caregivers, non-donor siblings from the donor-recipient families, and non-donor siblings of patients receiving unrelated transplants.

You may qualify if:

Participants must fall into one of the following categories:

Sponsors & Collaborators

Center for International Blood and Marrow Transplant Research
Research networklead
University of Pittsburgh
Othercollaborator

Study Sites (31)

University of Alabama at Birmingham

Birmingham, Alabama, 35233, United States

Phoenix Children's Hospital

Phoenix, Arizona, 85016, United States

City of Hope

Duarte, California, 91010, United States

Loma Linda University

Loma Linda, California, 92354, United States

Children's Hospital of Los Angeles

Los Angeles, California, 90027, United States

Rady Children's Hospital San Diego

San Diego, California, 92123, United States

University of California San Francisco Medical Center

San Francisco, California, 94143, United States

Study Officials

Galen Switzer, Ph.D
University of Pittsburgh
PRINCIPAL INVESTIGATOR

Enrollment

754 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: COHORT
Time Perspective: PROSPECTIVE
Sponsor Type: NETWORK
Responsible Party: SPONSOR

Study Record Dates

First Submitted

October 23, 2018

First Posted

October 24, 2018

Study Start

April 3, 2019

Actual (reported)

Identifying Predictors of Poor Health-Related Quality-of-Life Among Pediatric Hematopoietic Stem Cell Donors

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (6)

Sibling pediatric donors

Sibling recipients and caregivers

Non-donor sibling

Non-donor siblings

Healthy comparison

Parents

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (31)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (2)

Study Arms (6)

Sibling pediatric donors

Sibling recipients and caregivers

Non-donor sibling

Non-donor siblings

Healthy comparison

Parents

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (31)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations