NCT03704012

Brief Summary

The purpose of this study was to analyze the efficacy of massage therapy and kinesiotherapy, applied by the parents of hospitalized preterm infants, in the improvement of the biological state, neuromotor activity and other associated factors.

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
143

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Sep 2012

Longer than P75 for not_applicable

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 2012

Completed
4 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 2, 2013

Completed
3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2015

Completed
2.2 years until next milestone

First Submitted

Initial submission to the registry

February 23, 2018

Completed
8 months until next milestone

First Posted

Study publicly available on registry

October 12, 2018

Completed
Last Updated

October 12, 2018

Status Verified

October 1, 2018

Enrollment Period

4 months

First QC Date

February 23, 2018

Last Update Submit

October 3, 2018

Conditions

Keywords

Premature InfantMassageTactile Kinesthetic Stimulation

Outcome Measures

Primary Outcomes (4)

  • Effect on weight

    Effect of treatment on weight

    From baseline to hospital discharge, approximately 10 days

  • Effect of lenght

    Effect of treatment on lenght

    From baseline to hospital discharge, approximately 10 days

  • Effect on head circumference

    Effect of treatment on head circumference

    From baseline to hospital discharge, approimately 10 days

  • Effect on neuromotor development

    Effect of treatment on neuromotor development. Neuromotor development were measured using the Spanish Premie-Neuro Scale, a scale for the neurological examination of premature babies, between 23 and 37 gestational weeks. It consists of twenty-four items divided into three factors: Neurological, movement and responsiveness, each with eight items. Each of the items is assigned a score of 1, 3 or 5. The scores for items are added up to yield a total raw score, with the possible figures for this ranging from 24 to 120 (higher values represent a better neuromotor development).

    From baseline to up to 37 gestational weeks

Secondary Outcomes (1)

  • Average daily weight gain

    From baseline to hospital discharge, approimately 10 days

Study Arms (2)

Routine Care

NO INTERVENTION

Control Group receives routine care.

Massage and kinesiotherapy

EXPERIMENTAL

Intervention Group, receives massage and kinesiotherapy. Behavioral: Protocol of massage therapy and kinesiotherapy. Infants received massage and kinesiotherapy twice a day; 15 minutes each.

Behavioral: Protocol of massage therapy and kinesiotherapy

Interventions

Infants received massage and kinesiotherapy, applied by parents, twice a day; 15 minutes each.

Also known as: Massage, Massage Therapy, Tactile Kinesthetic Stimulation
Massage and kinesiotherapy

Eligibility Criteria

Age26 Weeks - 37 Weeks
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • Gestational age between 26 to 37 gestational weeks.
  • Low birth weight, less than 2249 grams.
  • Weight of at least 1250 grams at time of entry into study.
  • Must be at least 48 hours of age.
  • Must have hemodynamic stability.
  • Absence of congenital and genetic anomalies.
  • Absence of alterations of the central nervous system.
  • Intact skin.
  • Stable parameters (according to the neonatologist´s criteria) to participate in the intervention.

You may not qualify if:

  • Family refusal to participate in the study.
  • High frequency mechanical ventilation.
  • Fraction of Inspired Oxygen (FiO2)\>70%.
  • Inotropic support.
  • Septic shock.
  • Persistent tachycardia.
  • Persistent bradycardia.
  • Gastrointestinal disorders.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (3)

  • Alvarez MJ, Fernandez D, Gomez-Salgado J, Rodriguez-Gonzalez D, Roson M, Lapena S. The effects of massage therapy in hospitalized preterm neonates: A systematic review. Int J Nurs Stud. 2017 Apr;69:119-136. doi: 10.1016/j.ijnurstu.2017.02.009. Epub 2017 Feb 14.

  • Fernandez D, Alvarez MJ, Rodriguez D, Rodriguez M, Fernandez E, Urdiales P. Spanish Validation of the Premie-Neuro Scale in Premature Infants. J Pediatr Nurs. 2015 Jul-Aug;30(4):560-7. doi: 10.1016/j.pedn.2014.11.002. Epub 2014 Nov 26.

  • Alvarez-Alvarez MJ, Fernandez-Garcia D, Gomez-Salgado J, Ordas B, Rodriguez-Gonzalez MD, Martinez-Isasi S. Effectiveness of the application of massage therapy and kinesitherapy by parents on premature neonates: A research protocol. J Adv Nurs. 2019 Nov;75(11):3097-3104. doi: 10.1111/jan.14135. Epub 2019 Jul 30.

MeSH Terms

Conditions

Premature Birth

Interventions

Massage

Condition Hierarchy (Ancestors)

Obstetric Labor, PrematureObstetric Labor ComplicationsPregnancy ComplicationsFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital Diseases

Intervention Hierarchy (Ancestors)

Therapy, Soft TissueMusculoskeletal ManipulationsComplementary TherapiesTherapeuticsPhysical Therapy ModalitiesRehabilitation

Study Officials

  • Daniel Fernández-García, PhD

    Proffesor. Nursing and Physical Therapy Department. University of León.

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
SINGLE
Who Masked
INVESTIGATOR
Purpose
TREATMENT
Intervention Model
FACTORIAL
Model Details: The control group included all preterm infants from months 1-6 and 19-24 of the study. The intervention group included all the premature newborns from the 7-18 months of the study.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Collaborating Professor, Nursing and Physical Therapy Department, Universidad de León (Spain)

Study Record Dates

First Submitted

February 23, 2018

First Posted

October 12, 2018

Study Start

September 1, 2012

Primary Completion

January 2, 2013

Study Completion

December 30, 2015

Last Updated

October 12, 2018

Record last verified: 2018-10