NCT03703869

Brief Summary

Primary Objective: Assess effectiveness of insulin glargine (U300) in achieving glycemic goal measured by hemoglobin A1c (HbA1c). Secondary Objectives:

  • Assess effectiveness in achieving glycemic goal measured by HbA1c;
  • Assess effectiveness on change in HbA1c, fasting plasma glucose (FPG) and self-monitored plasma glucose (SMPG) ;
  • Assess requirement for intensification of therapy by additional antidiabetics.
  • Assess incidence of hypoglycemia;
  • Assess other safety endpoints: adverse events (AEs), serious adverse events (SAEs);
  • Assess change in body weight.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
4,589

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Mar 2018

Geographic Reach
18 countries

388 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 6, 2018

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

October 9, 2018

Completed
3 days until next milestone

First Posted

Study publicly available on registry

October 12, 2018

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 28, 2019

Completed
8 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 24, 2020

Completed
Last Updated

April 25, 2022

Status Verified

April 1, 2022

Enrollment Period

1.3 years

First QC Date

October 9, 2018

Last Update Submit

April 21, 2022

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in HbA1c at month 6

    Percentage of patients achieving Hemoglobin A1c \<7.0%.

    Baseline, month 6

Secondary Outcomes (7)

  • Change in HbA1c

    Baseline, months 3, 6, 12

  • Change in fasting plasma glucose

    Baseline, months 3, 6, 12

  • Change in Self-Monitored Plasma Glucose

    Baseline, months 3, 6, 12

  • Hypoglycemia

    Baseline to month 12

  • Adverse events

    Baseline to month 12

  • +2 more secondary outcomes

Study Arms (1)

Insulin glargine (U300)

Insulin glargine (U300) dosage and dosing time as per local product labeling

Drug: Insulin glargine (U300)

Interventions

Pharmaceutical form: Solution for injection Route of administration: Subcutaneous injection

Also known as: HOE901, Toujeo, Toujeo Solostar
Insulin glargine (U300)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Insulin-naïve patients with type 2 diabetes mellitus and Oral Antidiabetic Drug failure

You may qualify if:

  • Signed patient informed consent;
  • Type 2 diabetes mellitus;
  • Treated with at least 1 oral antidiabetic drug (OAD) for at least 6 months;
  • Hemoglobin A1c (HbA1c) \>7.0 % and ≤11% within 3 months of study baseline;
  • Physicians' decision in accordance with the current local guidelines to add basal insulin glargine U300 to an existing OAD regimen

You may not qualify if:

  • Diabetes mellitus other than type 2;
  • Contraindication to insulin glargine U300 according to local product labelling;
  • The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (388)

Investigational Site Number 1700001

Barranquilla, Colombia

Location

Investigational Site Number 1700004

Bogotá, Colombia

Location

Investigational Site Number 1700010

Bogotá, Colombia

Location

Investigational Site Number 1700005

Cali, Colombia

Location

Investigational Site Number 1700009

Cali, Colombia

Location

Investigational Site Number 1700003

Ibagué, Colombia

Location

Investigational Site Number 1700007

Manizales, 170, Colombia

Location

Investigational Site Number 1700006

Popayán, Colombia

Location

Investigational Site Number 1700002

Zipaquirá, Colombia

Location

Investigational Site Number 8180017

Al Mansurah, Egypt

Location

Investigational Site Number 8180015

Alexandria, 21575, Egypt

Location

Investigational Site Number 8180007

Alexandria, Egypt

Location

Investigational Site Number 8180008

Alexandria, Egypt

Location

Investigational Site Number 8180012

Alexandria, Egypt

Location

Investigational Site Number 8180018

Alexandria, Egypt

Location

Investigational Site Number 8180001

Cairo, Egypt

Location

Investigational Site Number 8180005

Cairo, Egypt

Location

Investigational Site Number 8180006

Cairo, Egypt

Location

Investigational Site Number 8180016

Cairo, Egypt

Location

Investigational Site Number 8180020

Cairo, Egypt

Location

Investigational Site Number 8180003

Giza, 11535, Egypt

Location

Investigational Site Number 8180011

Giza, 28452, Egypt

Location

Investigational Site Number 8180002

Giza, Egypt

Location

Investigational Site Number 8180009

Giza, Egypt

Location

Investigational Site Number 8180014

Giza, Egypt

Location

Investigational Site Number 8180013

Portsaeid, Egypt

Location

Investigational Site Number 3560056

Ahmedabad, 380006, India

Location

Investigational Site Number 3560021

Ahmedabad, 380007, India

Location

Investigational Site Number 3560049

Ahmedabad, 380009, India

Location

Investigational Site Number 3560077

Ahmedabad, 380009, India

Location

Investigational Site Number 3560068

Ahmedabad, 380054, India

Location

Investigational Site Number 3560014

Aurangabad, 431001, India

Location

Investigational Site Number 3560081

Bangalore, 560005, India

Location

Investigational Site Number 3560088

Bangalore, 560019, India

Location

Investigational Site Number 3560066

Bangalore, 560078, India

Location

Investigational Site Number 3560009

Bangalore, 560079, India

Location

Investigational Site Number 3560059

Bangalore, India

Location

Investigational Site Number 3560064

Bangalore, India

Location

Investigational Site Number 3560075

Bangalore, India

Location

Investigational Site Number 3560122

Bangalore, India

Location

Investigational Site Number 3560044

Belagavi, India

Location

Investigational Site Number 3560074

Bengaluru, 560003, India

Location

Investigational Site Number 3560046

Bengaluru, 560040, India

Location

Investigational Site Number 3560116

Bhabaneswar, 751012, India

Location

Investigational Site Number 3560062

Bhubaneswar, 751003, India

Location

Investigational Site Number 3560106

Chandigarh, 160012, India

Location

Investigational Site Number 3560126

Chandigarh, 160043, India

Location

Investigational Site Number 3560110

Chennai, 600005, India

Location

Investigational Site Number 3560029

Chennai, 600008, India

Location

Investigational Site Number 3560080

Chennai, 600014, India

Location

Investigational Site Number 3560067

Chennai, 600017, India

Location

Investigational Site Number 3560030

Chennai, 600032, India

Location

Investigational Site Number 3560008

Chennai, 600040, India

Location

Investigational Site Number 3560031

Chennai, 600042, India

Location

Investigational Site Number 3560011

Chennai, 600083, India

Location

Investigational Site Number 3560124

Chennai, 600085, India

Location

Investigational Site Number 3560105

Chennai, 600090, India

Location

Investigational Site Number 3560098

Chennai, 600100, India

Location

Investigational Site Number 3560104

Chennai, 600106, India

Location

Investigational Site Number 3560133

Chennai, India

Location

Investigational Site Number 3560012

Coimbatore, 641004, India

Location

Investigational Site Number 3560131

Coimbatore, 641009, India

Location

Investigational Site Number 3560032

Delhi, 110005, India

Location

Investigational Site Number 3560041

Delhi, 110017, India

Location

Investigational Site Number 3560108

Delhi, 110021, India

Location

Investigational Site Number 3560002

Delhi, 110060, India

Location

Investigational Site Number 3560019

Delhi, 110063, India

Location

Investigational Site Number 3560047

Delhi, 110063, India

Location

Investigational Site Number 3560102

Delhi, 110076, India

Location

Investigational Site Number 3560020

Delhi, 110085, India

Location

Investigational Site Number 3560085

Delhi, 110087, India

Location

Investigational Site Number 3560118

Erode, 638011, India

Location

Investigational Site Number 3560051

Guwahati, 781001, India

Location

Investigational Site Number 3560094

Guwahati, 781005, India

Location

Investigational Site Number 3560087

Guwahati, 781006, India

Location

Investigational Site Number 3560113

Guwahati, 781006, India

Location

Investigational Site Number 3560070

Guwahati, 781011, India

Location

Investigational Site Number 3560097

Guwahati, 781022, India

Location

Investigational Site Number 3560109

Gwalior, 474001, India

Location

Investigational Site Number 3560089

Haryāna, India

Location

Investigational Site Number 3560135

Howrah, 711201, India

Location

Investigational Site Number 3560096

Howrah, India

Location

Investigational Site Number 3560045

Hyderabad, 500002, India

Location

Investigational Site Number 3560058

Hyderabad, 500016, India

Location

Investigational Site Number 3560036

Hyderabad, 500029, India

Location

Investigational Site Number 3560069

Hyderabad, 500033, India

Location

Investigational Site Number 3560035

Hyderabad, 500073, India

Location

Investigational Site Number 3560024

Hyderabad, 500081, India

Location

Investigational Site Number 3560027

Hyderabad, India

Location

Investigational Site Number 3560043

Hyderabad, India

Location

Investigational Site Number 3560100

Hyderabad, India

Location

Investigational Site Number 3560107

Hyderabad, India

Location

Investigational Site Number 3560034

Hyderabd, India

Location

Investigational Site Number 3560111

Jaipur, 302015, India

Location

Investigational Site Number 3560123

Jaipur, 302015, India

Location

Investigational Site Number 3560134

Jaipur, 302016, India

Location

Investigational Site Number 3560017

Jaipur, 302018, India

Location

Investigational Site Number 3560022

Jaipur, India

Location

Investigational Site Number 3560073

Jalandhar, 144003, India

Location

Investigational Site Number 3560005

Kanpur, 208002, India

Location

Investigational Site Number 3560125

Kanpur, 208002, India

Location

Investigational Site Number 3560026

Kochi, 682019, India

Location

Investigational Site Number 3560018

Kochi, 682020, India

Location

Investigational Site Number 3560050

Kochi, 682041, India

Location

Investigational Site Number 3560016

Kochi, India

Location

Investigational Site Number 3560091

Kolkata, 700020, India

Location

Investigational Site Number 3560083

Kolkata, India

Location

Investigational Site Number 3560090

Kolkata, India

Location

Investigational Site Number 3560092

Kolkata, India

Location

Investigational Site Number 3560093

Kolkata, India

Location

Investigational Site Number 3560099

Kolkata, India

Location

Investigational Site Number 3560115

Kolkata, India

Location

Investigational Site Number 3560120

Kolkata, India

Location

Investigational Site Number 3560129

Kolkata, India

Location

Investigational Site Number 3560130

Kolkata, India

Location

Investigational Site Number 3650120

Kolkata, India

Location

Investigational Site Number 3560103

Lucknow, India

Location

Investigational Site Number 3560117

Madurai, 625020, India

Location

Investigational Site Number 3560033

Mumbai, 400005, India

Location

Investigational Site Number 3560121

Mumbai, 400007, India

Location

Investigational Site Number 3560136

Mumbai, 400053, India

Location

Investigational Site Number 3560042

Mumbai, 400064, India

Location

Investigational Site Number 3560065

Mumbai, 400068, India

Location

Investigational Site Number 3560015

Mumbai, 400092, India

Location

Investigational Site Number 3560079

Mumbai, 400601, India

Location

Investigational Site Number 3560003

Mumbai, India

Location

Investigational Site Number 3560023

Mumbai, India

Location

Investigational Site Number 3560040

Mumbai, India

Location

Investigational Site Number 3560119

Mumbai, India

Location

Investigational Site Number 3560112

Navi Mumbai, 400706, India

Location

Investigational Site Number 3560010

Nellore, 524001, India

Location

Investigational Site Number 3560086

Noida, India

Location

Investigational Site Number 3560132

Noida, India

Location

Investigational Site Number 3560053

Puducherry, 605005, India

Location

Investigational Site Number 3560004

Pune, 411001, India

Location

Investigational Site Number 3560038

Pune, 411004, India

Location

Investigational Site Number 3560055

Pune, 411021, India

Location

Investigational Site Number 3560060

Pune, 411037, India

Location

Investigational Site Number 3560072

Rajahmundry, 533103, India

Location

Investigational Site Number 3560025

Rajkot, 360001, India

Location

Investigational Site Number 3560076

Rajkot, 360002, India

Location

Investigational Site Number 3560063

Surat, India

Location

Investigational Site Number 3560084

Tinsukia, 786125, India

Location

Investigational Site Number 3560006

Trichy, 620017, India

Location

Investigational Site Number 3560001

Trichy, 620018, India

Location

Investigational Site Number 3560101

Trichy, 620018, India

Location

Investigational Site Number 3560114

Tripura, 799001, India

Location

Investigational Site Number 3560039

Trivandrum, 695033, India

Location

Investigational Site Number 3560013

Trivandrum, India

Location

Investigational Site Number 3560127

Vijayawada, 520002, India

Location

Investigational Site Number 3560061

Visakhapatnam, 530002, India

Location

Investigational Site Number 3560054

Visakhapatnam, 530016, India

Location

Investigational Site Number 3560128

Yamuna Nagar, India

Location

Investigational Site Number 3600003

Denpasar, 80234, Indonesia

Location

Investigational Site Number 3600001

Jakarta, 10220, Indonesia

Location

Investigational Site Number 3600002

Jakarta, 10630, Indonesia

Location

Investigational Site Number 3760001

Haifa, Israel

Location

Investigational Site Number 3760002

Petah Tikva, Israel

Location

Investigational Site Number 3760005

Rishon LeZiyyon, Israel

Location

Investigational Site Number 3760003

Tel Aviv, Israel

Location

Investigational Site Number 3760004

Tel Aviv, Israel

Location

Investigational Site Number 4000002

Amman, 11183, Jordan

Location

Investigational Site Number 4000005

Amman, 11183, Jordan

Location

Investigational Site Number 4000006

Amman, 11183, Jordan

Location

Investigational Site Number 4000008

Amman, 11183, Jordan

Location

Investigational Site Number 0004

Amman, Jordan

Location

Investigational Site Number 4000009

Amman, Jordan

Location

Investigational Site Number 0007

Irbid, 211-81, Jordan

Location

Investigational Site Number 4140001

Al Jabriya, Kuwait

Location

Investigational Site Number 4140010

Al Jabriya, Kuwait

Location

Investigational Site Number 4140003

Kuwait City, Kuwait

Location

Investigational Site Number 4140004

Kuwait City, Kuwait

Location

Investigational Site Number 4140006

Kuwait City, Kuwait

Location

Investigational Site Number 4140009

Kuwait City, Kuwait

Location

Investigational Site Number 4140011

Kuwait City, Kuwait

Location

Investigational Site Number 4140012

Kuwait City, Kuwait

Location

Investigational Site Number 4220017

Airport Road, Lebanon

Location

Investigational Site Number 4220008

Aley, Lebanon

Location

Investigational Site Number 4220001

Beirut, Lebanon

Location

Investigational Site Number 4220015

Beirut, Lebanon

Location

Investigational Site Number 4220012

Bir Al Abed, Lebanon

Location

Investigational Site Number 4220007

Chtoura, Lebanon

Location

Investigational Site Number 4220011

Corniche El Mazraa, Lebanon

Location

Investigational Site Number 4220006

El Achrafiyé, Lebanon

Location

Investigational Site Number 4220016

El Achrafiyé, Lebanon

Location

Investigational Site Number 4220018

Hadath, Lebanon

Location

Investigational Site Number 4220013

Hamra, Lebanon

Location

Investigational Site Number 4220019

Jal El Baher, Lebanon

Location

Investigational Site Number 4220014

Jounieh, Lebanon

Location

Investigational Site Number 4220010

Metn, Lebanon

Location

Investigational Site Number 4220004

Mount Lebanon, Lebanon

Location

Investigational Site Number 4220005

Saida, Lebanon

Location

Investigational Site Number 4220003

Sarba, Lebanon

Location

Investigational Site Number 4220009

Tyre, Lebanon

Location

Investigational Site Number 4840001

Aguascalientes, 20230, Mexico

Location

Investigational Site Number 4840009

Celaya, 38000, Mexico

Location

Investigational Site Number 4840008

Chihuahua City, 31200, Mexico

Location

Investigational Site Number 4840004

Cuernavaca, 62250, Mexico

Location

Investigational Site Number 4840007

Durango, Mexico

Location

Investigational Site Number 4840006

Guadalajara, 44130, Mexico

Location

Investigational Site Number 4840003

Guadalajara, 44500, Mexico

Location

Investigational Site Number 4840005

México, 06470, Mexico

Location

Investigational Site Number 4840010

México, 07760, Mexico

Location

Investigational Site Number 4840002

México, 40100, Mexico

Location

Investigational Site Number 6040003

Arequipa, Peru

Location

Investigational Site Number 6040001

Lima, Peru

Location

Investigational Site Number 6040002

Lima, Peru

Location

Investigational Site Number 6080001

Dasmarinas Cavite, 4114, Philippines

Location

Investigational Site Number 6430108

Anapa, 353440, Russia

Location

Investigational Site Number 6430170

Arkhangelsk, 163045, Russia

Location

Investigational Site Number 6430171

Arkhangelsk, 163045, Russia

Location

Investigational Site Number 6430172

Arkhangelsk, 163045, Russia

Location

Investigational Site Number 6430019

Astrakhan, 414018, Russia

Location

Investigational Site Number 6430010

Barnaul, 656050, Russia

Location

Investigational Site Number 6430138

Barnaul, 656050, Russia

Location

Investigational Site Number 6430081

Barnaul, 656056, Russia

Location

Investigational Site Number 6430182

Barnaul, 656056, Russia

Location

Investigational Site Number 6430160

Barnaul, 656066, Russia

Location

Investigational Site Number 6430181

Barnaul, 656922, Russia

Location

Investigational Site Number 6430157

Belorechensk, 352630, Russia

Location

Investigational Site Number 6430156

Bryansk, 241047, Russia

Location

Investigational Site Number 6430060

Chaltyr, 346801, Russia

Location

Investigational Site Number 6430087

Cheboksary, 428009, Russia

Location

Investigational Site Number 6430097

Chelyabinsk, 454046, Russia

Location

Investigational Site Number 6430036

Chelyabinsk, 454076, Russia

Location

Investigational Site Number 6430092

Chelyabinsk, 454084, Russia

Location

Investigational Site Number 6430107

Chelyabinsk, 454091, Russia

Location

Investigational Site Number 6430111

Gorodets, 606500, Russia

Location

Investigational Site Number 6430012

Kazan', 420064, Russia

Location

Investigational Site Number 6430184

Kazan', 420103, Russia

Location

Investigational Site Number 6430011

Kemerovo, 650066, Russia

Location

Investigational Site Number 6430109

Kemerovo, 650066, Russia

Location

Investigational Site Number 6430072

Kemerovo, 650099, Russia

Location

Investigational Site Number 6430125

Kolomna, 140405, Russia

Location

Investigational Site Number 6430143

Krasnodar, 350000, Russia

Location

Investigational Site Number 6430047

Krasnodar, 350001, Russia

Location

Investigational Site Number 6430136

Krasnodar, 350002, Russia

Location

Investigational Site Number 6430083

Krasnodar, 350072, Russia

Location

Investigational Site Number 6430140

Krasnodar, 350075, Russia

Location

Investigational Site Number 6430021

Krasnodar, 350915, Russia

Location

Investigational Site Number 6430115

Krasnoyarsk, 660003, Russia

Location

Investigational Site Number 6430004

Krasnoyarsk, 660052, Russia

Location

Investigational Site Number 6430068

Lipetsk, 398043, Russia

Location

Investigational Site Number 6430067

Lipetsk, Russia

Location

Investigational Site Number 6430024

Livny, 303858, Russia

Location

Investigational Site Number 6430128

Moscow, 105005, Russia

Location

Investigational Site Number 6430168

Moscow, 105005, Russia

Location

Investigational Site Number 6430064

Moscow, 109145, Russia

Location

Investigational Site Number 6430065

Moscow, 109457, Russia

Location

Investigational Site Number 6430148

Moscow, 111555, Russia

Location

Investigational Site Number 6430079

Moscow, 115211, Russia

Location

Investigational Site Number 6430101

Moscow, 115409, Russia

Location

Investigational Site Number 6430100

Moscow, 115516, Russia

Location

Investigational Site Number 6430120

Moscow, 115516, Russia

Location

Investigational Site Number 6430130

Moscow, 115516, Russia

Location

Investigational Site Number 6430026

Moscow, 119311, Russia

Location

Investigational Site Number 6430005

Moscow, 121601, Russia

Location

Investigational Site Number 6430017

Moscow, 124482, Russia

Location

Investigational Site Number 6430027

Moscow, 125222, Russia

Location

Investigational Site Number 6430057

Moscow, 125373, Russia

Location

Investigational Site Number 6430035

Moscow, 127018, Russia

Location

Investigational Site Number 6430118

Moscow, 127273, Russia

Location

Investigational Site Number 6430146

Moscow, 127549, Russia

Location

Investigational Site Number 6430147

Moscow, 141411, Russia

Location

Investigational Site Number 6430051

Moscow, Russia

Location

Investigational Site Number 6430149

Moscow, Russia

Location

Investigational Site Number 6430132

Nizhny Novgorod, 603004, Russia

Location

Investigational Site Number 6430066

Nizhny Novgorod, 603035, Russia

Location

Investigational Site Number 6430129

Nizhny Novgorod, 603163, Russia

Location

Investigational Site Number 6430110

Novomoskovsk, 301650, Russia

Location

Investigational Site Number 6430007

Novosibirsk, 630047, Russia

Location

Investigational Site Number 6430061

Novosibirsk, 630060, Russia

Location

Investigational Site Number 6430023

Novosibirsk, 630106, Russia

Location

Investigational Site Number 6430117

Omsk, 644010, Russia

Location

Investigational Site Number 6430014

Orenburg, 460018, Russia

Location

Investigational Site Number 6430112

Oryol, 302030, Russia

Location

Investigational Site Number 6430137

Oryol, Russia

Location

Investigational Site Number 6430039

Penza, 440052, Russia

Location

Investigational Site Number 6430164

Penza, 440052, Russia

Location

Investigational Site Number 6430126

Perm, Russia

Location

Investigational Site Number 6430040

Petrozavodsk, 185014, Russia

Location

Investigational Site Number 6430054

Petrozavodsk, 185014, Russia

Location

Investigational Site Number 6430084

Petrozavodsk, 185014, Russia

Location

Investigational Site Number 6430038

Pushkin, 196607, Russia

Location

Investigational Site Number 6430151

Rostov-on-Don, 344029, Russia

Location

Investigational Site Number 6430090

Rostov-on-Don, 344092, Russia

Location

Investigational Site Number 6430037

Rybinsk, 152912, Russia

Location

Investigational Site Number 6430086

Saint Petersburg, 19323, Russia

Location

Investigational Site Number 6430139

Saint Petersburg, 19323, Russia

Location

Investigational Site Number 6430022

Saint Petersburg, 193312, Russia

Location

Investigational Site Number 6430070

Saint Petersburg, 194156, Russia

Location

Investigational Site Number 643085

Saint Petersburg, 195220, Russia

Location

Investigational Site Number 6430028

Saint Petersburg, 195256, Russia

Location

Investigational Site Number 6430074

Saint Petersburg, 195256, Russia

Location

Investigational Site Number 6430135

Saint Petersburg, 195256, Russia

Location

Investigational Site Number 6430150

Saint Petersburg, 195256, Russia

Location

Investigational Site Number 6430095

Saint Petersburg, 195426, Russia

Location

Investigational Site Number 6430032

Saint Petersburg, 197082, Russia

Location

Investigational Site Number 6430144

Saint Petersburg, 197101, Russia

Location

Investigational Site Number 6430031

Saint Petersburg, 197341, Russia

Location

Investigational Site Number 6430099

Saint Petersburg, 197349, Russia

Location

Investigational Site Number 6430131

Saint Petersburg, 197349, Russia

Location

Investigational Site Number 6430163

Saint Petersburg, 197371, Russia

Location

Investigational Site Number 6430152

Saint Petersburg, 199155, Russia

Location

Investigational Site Number 6430073

Sal'sk, 347630, Russia

Location

Investigational Site Number 6430177

Samara, 443031, Russia

Location

Investigational Site Number 6430046

Samara, 443111, Russia

Location

Investigational Site Number 6430029

Shatura, 140700, Russia

Location

Investigational Site Number 6430155

Smolensk, 214006, Russia

Location

Investigational Site Number 6430121

Smolensk, 214019, Russia

Location

Investigational Site Number 6430089

Sochi, 354382, Russia

Location

Investigational Site Number 6430044

Stavropol, 355035, Russia

Location

Investigational Site Number 6430134

Stavropol, 355035, Russia

Location

Investigational Site Number 6430153

Stavropol, 355035, Russia

Location

Investigational Site Number 6430076

Tambov, 392023, Russia

Location

Investigational Site Number 6430142

Tambov, 392023, Russia

Location

Investigational Site Number 6430013

Tolyatti, 445000, Russia

Location

Investigational Site Number 6430058

Tomsk, 634034, Russia

Location

Investigational Site Number 6430030

Tver', 170019, Russia

Location

Investigational Site Number 6430169

Tver', 170028, Russia

Location

Investigational Site Number 6430166

Tver', 170036, Russia

Location

Investigational Site Number 6430123

Tyumen, 625003, Russia

Location

Investigational Site Number 6430098

Tyumen, 625031, Russia

Location

Investigational Site Number 6430078

Tyumen, 660077, Russia

Location

Investigational Site Number 6430189

Ufa, 450099, Russia

Location

Investigational Site Number 6430041

Ulyanovsk, 432063, Russia

Location

Investigational Site Number 6430114

Vladimir, Russia

Location

Investigational Site Number 6430018

Volgograd, 400001, Russia

Location

Investigational Site Number 6430052

Vsevolozhsk, Russia

Location

Investigational Site Number 6430008

Vyksa, 607060, Russia

Location

Investigational Site Number 6430055

Yaroslavl, 150042, Russia

Location

Investigational Site Number 6430033

Yartsevo, Russia

Location

Investigational Site Number 6430006

Yoshkar-Ola, Russia

Location

Investigational Site Number 6820009

Al Ehsa, Saudi Arabia

Location

Investigational Site Number 6820006

Jeddah, 21412, Saudi Arabia

Location

Investigational Site Number 6820001

Jeddah, 21589, Saudi Arabia

Location

Investigational Site Number 6820008

Jeddah, Saudi Arabia

Location

Investigational Site Number 6820010

Jeddah, Saudi Arabia

Location

Investigational Site Number 6820007

Jubail, Saudi Arabia

Location

Investigational Site Number 6820004

Najrān, Saudi Arabia

Location

Investigational Site Number 6820003

Riyadh, Saudi Arabia

Location

Investigational Site Number 7020001

Singapore, 308433, Singapore

Location

Investigational Site Number 1580007

Changhua, 500, Taiwan

Location

Investigational Site Number 1580005

Kaohsiung Hsien,, Taiwan

Location

Investigational Site Number 1580003

New Taipei City, Taiwan

Location

Investigational Site Number 1580004

Taichung, 402, Taiwan

Location

Investigational Site Number 1580002

Tainan, Taiwan

Location

Investigational Site Number 1580006

Taipei, 100, Taiwan

Location

Investigational Site Number 7640002

Bangkok, 10400, Thailand

Location

Investigational Site Number 7640001

Bangkok, Thailand

Location

Investigational Site Number 8040020

Cherkasy, 18009, Ukraine

Location

Investigational Site Number 8040002

Chernivtsi, 58022, Ukraine

Location

Investigational Site Number 8040006

Dnipro, 49005, Ukraine

Location

Investigational Site Number 8040014

Dnipro, 49038, Ukraine

Location

Investigational Site Number 8040010

Ivano-Frankivsk, 76008, Ukraine

Location

Investigational Site Number 8040013

Kharkiv, 61037, Ukraine

Location

Investigational Site Number 8040016

Kharkiv, 61037, Ukraine

Location

Investigational Site Number 8040001

Kharkiv, 61157, Ukraine

Location

Investigational Site Number 8040012

Khmelnytskyi, 29000, Ukraine

Location

Investigational Site Number 8040019

Kyiv, 02091, Ukraine

Location

Investigational Site Number 8040005

Kyiv, 04053, Ukraine

Location

Investigational Site Number 8040008

Kyiv, 04073, Ukraine

Location

Investigational Site Number 8040011

Kyiv, 04114, Ukraine

Location

Investigational Site Number 8040017

Kyiv, 04114, Ukraine

Location

Investigational Site Number 8040007

Poltava, 36003, Ukraine

Location

Investigational Site Number 8040004

Sumy, 40022, Ukraine

Location

Investigational Site Number 8040009

Ternopil, 46002, Ukraine

Location

Investigational Site Number 8040018

Ternopil, 46002, Ukraine

Location

Investigational Site Number 8040003

Vinnytsia, 21010, Ukraine

Location

Investigational Site Number 8040015

Zaporizhzhia, 69001, Ukraine

Location

Investigational Site Number 7840017

Abu Dhabi, United Arab Emirates

Location

Investigational Site Number 7840018

Abu Dhabi, United Arab Emirates

Location

Investigational Site Number 7840007

Ajman, United Arab Emirates

Location

Investigational Site Number 7840001

Dubai, United Arab Emirates

Location

Investigational Site Number 7840002

Dubai, United Arab Emirates

Location

Investigational Site Number 7840003

Dubai, United Arab Emirates

Location

Investigational Site Number 7840004

Dubai, United Arab Emirates

Location

Investigational Site Number 7840005

Dubai, United Arab Emirates

Location

Investigational Site Number 7840008

Dubai, United Arab Emirates

Location

Investigational Site Number 7840009

Dubai, United Arab Emirates

Location

Investigational Site Number 7840010

Dubai, United Arab Emirates

Location

Investigational Site Number 7840012

Dubai, United Arab Emirates

Location

Investigational Site Number 7840013

Dubai, United Arab Emirates

Location

Investigational Site Number 7840014

Dubai, United Arab Emirates

Location

Investigational Site Number 7840015

Dubai, United Arab Emirates

Location

Investigational Site Number 7840016

Dubai, United Arab Emirates

Location

Investigational Site Number 7840019

Umm Al Quwain City, United Arab Emirates

Location

Investigational Site Number 7840020

Umm Al Quwain City, United Arab Emirates

Location

Related Publications (3)

  • Tirosh A, Khan N, Vargas-Uricoechea H, Galstyan G, Al Shaikh AR, Makkar BM, Mabunay MA, Melas-Melt L, Pilorget V, Karalliedde J. Effectiveness and Safety of Insulin Glargine 300 U/ml in High-Risk Subgroups (Renal Impairment and Older Age >/= 70 years) of Insulin-Naive People with Type 2 Diabetes: A Post hoc Analysis of Real-World ATOS Study. Diabetes Ther. 2025 Oct;16(10):2045-2061. doi: 10.1007/s13300-025-01785-w. Epub 2025 Sep 8.

  • Khan NE, Al Shaikh AAM, Hassoun AAK, Hassan AM, Salah MM, Al Abdella NA, Safarini SSM, Al Dahi WA, Akil YA. Real-World Study on Effectiveness of Insulin Glargine U300 After Oral Antidiabetic Drug Failure in Patients with Type 2 Diabetes in the Gulf Region. Diabetes Ther. 2024 Mar;15(3):691-704. doi: 10.1007/s13300-024-01537-2. Epub 2024 Feb 15.

  • Galstyan GR, Tirosh A, Vargas-Uricoechea H, Mabunay MA, Coudert M, Naqvi M, Pilorget V, Khan N. Real-World Effectiveness and Safety of Insulin Glargine 300 U/mL in Insulin-Naive People with Type 2 Diabetes: the ATOS Study. Diabetes Ther. 2022 Jun;13(6):1187-1202. doi: 10.1007/s13300-022-01266-4. Epub 2022 May 9.

MeSH Terms

Conditions

Diabetes Mellitus

Interventions

Insulin Glargine

Condition Hierarchy (Ancestors)

Glucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System Diseases

Intervention Hierarchy (Ancestors)

Insulin, Long-ActingInsulinsPancreatic HormonesPeptide HormonesHormonesHormones, Hormone Substitutes, and Hormone AntagonistsPeptidesAmino Acids, Peptides, and Proteins

Study Officials

  • Clinical Sciences & Operations

    Sanofi

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

October 9, 2018

First Posted

October 12, 2018

Study Start

March 6, 2018

Primary Completion

June 28, 2019

Study Completion

February 24, 2020

Last Updated

April 25, 2022

Record last verified: 2022-04

Data Sharing

IPD Sharing
Will share

Qualified researchers may request access to patient level data and related study documents including the clinical study report, study protocol with any amendments, blank case report form, statistical analysis plan, and dataset specifications. Patient level data will be anonymized and study documents will be redacted to protect the privacy of trial participants. Further details on Sanofi's data sharing criteria, eligible studies, and process for requesting access can be found at: https://vivli.org

Locations