Cardiac Arrest Pursuit Trial With Unique Registration and Epidemiologic Surveillance

NCT03700203 | Recruiting

• 1 other identifier: 2017NE330060
• Study Type: observational
• Target: 5,340
• Locations: 1 country
• Sites: 1

Brief Summary

Identification of Causes and Risk Factors for Out-of-Hospital Cardiac Arrest through Development of Prediction Model and Novel Biomarkers Study Objectives:

1. 1.To identify causes and risk factors of OHCA incidence that are associated with chronic diseases and health behaviors
2. 2.To identify high risk population for OHCA incidence through development of a prediction model
3. 3.To develop novel biomarkers associated with OHCA incidence, survival, and disabilities

Conditions

Cardiac Arrest, Out-Of-Hospital

Keywords

Cardiac Arrest

Outcome Measures

Primary Outcomes (1)

• Number of Participants With Out-of-hospital Cardiac Arrests

  Number of participants with out-of-hospital cardiac arrests, from 19 to 79 years old.

  A total 1,780 cases (200 cases between September 2017 and August 2018, 600 cases between September 2018 and August 2020, 80 cases between September 2020 and December 2020, and 900 cases between January 2021 and December 2023)

Study Arms (2)

Early cardiac arrest patients

Cases will be consecutive adult patients with EMS-treated OHCA and transport to the 14 emergency departments of participating hospitals. A prospective OHCA patient cohort will be developed and all survived OHCA cases will be followed at 1-month and 6-month after ED discharge by telephone. During the study period, the investigators aim to recruit a total 1,780 cases (200 cases between September 2017 and August 2018, 600 cases between September 2018 and August 2020, 80 cases between September 2020 and December 2020, and 900 cases between January 2021 and December 2023).

Matched community-based controls

Matched community-based controls (2:1 matching) will be selected from two health screening centers. Controls are those who visit the participating health screening centers for their annual routine physical examinations. During the study period, the investigators aim to recruit a total 3,560 controls (400 controls between September 2017 and August 2018, 1200 controls between September 2018 and August 2020, 160 controls between September 2020 and December 2020, and 1800 controls between January 2021 and December 2023).

Eligibility Criteria

• Age: 19 Years - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

* Cases will be consecutive adult patients with EMS-treated OHCA and transport to the 14 emergency departments of participating hospitals. * Matched community-based controls (2:1 matching) will be selected from two health screening centers. Controls are those who visit the participating health screening centers for their health screening program.

You may qualify if:

• to 79 years old
• Out-of-hospital-cardiac arrest providing resuscitation at the site and visiting the emergency department of the participating hospital or transporting from another hospital emergency room (EMS-treated OHCA)
• The cardiac arrest event must not have been predicted for 24 hours before the incident

You may not qualify if:

• People who do not consent to personal information and blood supply for research
• Trauma, submersion, poisoning, hanging, suffocation, or other causes of external causes directly contribute to the cardiac arrest
• Patients with a terminal condition known to have no further treatment plans due to malignancy, neurological disease, respiratory disease, rheumatic disease, hematologic disease, renal disease or infectious disease. The terminal condition had to be checked by a doctor or recorded in medical records.
• "Do not have a resuscitation" card or record issued by a doctor.
• Hospice setting at the time of acute cardiac arrest for terminal illness or other reasons.
• pregnant patient
• With a family cannot provide information about patient
• Without a family
• Patients who were transported after admission at the other hospital
• Foreign patients

Sponsors & Collaborators

• Seoul National University Hospital: lead
• Korean Center for Disease Control and Prevention: collaborator

Study Sites (1)

Seoul National University Hospital

Seoul, 110-744, South Korea

RECRUITING

Related Publications (1)

• Jung E, Ryu HH, Ro YS, Cha KC, Shin SD, Hwang SO. Interactions between Sleep Apnea and Coronary Artery Disease on the Incidence of Sudden Cardiac Arrest: A Multi-Center Case-Control Study. Yonsei Med J. 2023 Jan;64(1):48-53. doi: 10.3349/ymj.2022.0417.

  PMID: 36579379 DERIVED

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest; Heart Arrest

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Jeong Ho Park

CONTACT

82-10-3542-6282; timthe@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Months
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 21, 2018
• First Posted: October 9, 2018
• Study Start: September 7, 2017
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: January 7, 2026

Record last verified: 2025-12

Locations

KR (1)