Brain Oxygenation During Cardiopulmonary Resuscitation

NCT03464123 | Completed

• 1 other identifier: 54/13/03/02/16
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The study is aimed to assess (a) the incidence of hyperoxia at the point of return of spontaneous circulation (ROSC) and (b) the role of arterial blood oxygen partial pressure to brain oxygenation during out-of-hospital cardiac arrest. 80 adult patients will be recruited in a physician staffed helicopter emergency medical services. Brain regional oxygen saturation and invasive blood pressure are monitored until hospital admission and arterial blood gases are analyzed immediately when the unit arrives to the patient and again at the time of ROSC.

Conditions

Cardiac Arrest, Out-Of-Hospital

Outcome Measures

Primary Outcomes (1)

• Arterial oxygen partial pressure

  Arterial oxygen partial pressure at the time of return of spontaneous circulation (ROSC)

  5-60 minutes

Secondary Outcomes (1)

• Forehead regional oxygen saturation during resuscitation

  0-60 minutes

Interventions

Standard cardiopulmonary resuscitation OTHER

Standard Advanced Life Support based on guidelines 2015, including mechanical chest compression device

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All adult patients met in cardiac arrest by the physician-led prehospital critical care team are to be screened and recruited based the eligibility criteria. The patients include patients in all primary rhythms.

You may qualify if:

• out-of-hospital cardiac arrest of presumed cardiac origin
• resuscitation will be continued at least 5 minutes (if return of spontaneous circulation not achieved earlier) after arrival of physician team

You may not qualify if:

• do-not-attempt-resuscitation (DNAR) order or withdrawal of treatment by prehospital critical care physician
• return of spontaneous circulation achieved before physician-led critical team arrives
• external cause for cardiac arrest (e.g. trauma, suffocation)
• workload too high or environment too dangerous to perform study procedures

Sponsors & Collaborators

• Helsinki University Central Hospital: lead

Study Sites (1)

FinnHEMS 10, Emergency Medicine and Services, Helsinki University Hospital

Vantaa, Finland

Location

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest

Condition Hierarchy (Ancestors)

Heart Arrest; Heart Diseases; Cardiovascular Diseases

Study Officials

• Jouni Nurmi, MD, PhD

  Helsinki University Central Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Consultant in Anaesthesia and Intensive Care Medicine

Study Record Dates

• First Submitted: February 9, 2018
• First Posted: March 13, 2018
• Study Start: February 24, 2017
• Primary Completion: April 30, 2019
• Study Completion: April 30, 2019
• Last Updated: May 9, 2019

Record last verified: 2019-05

Data Sharing

• IPD Sharing: Will not share

Locations

FI (1)