NCT03694522

Brief Summary

The main objective of the Phase 2 part of the study is to evaluate the efficacy of bemarituzumab (FPA144), a targeted antibody, in combination with modified FOLFOX6 compared to placebo in combination with modified FOLFOX6 in participants with advanced gastrointestinal cancer.

Trial Health

98
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
155

participants targeted

Target at P75+ for phase_2 gastric-cancer

Timeline
Completed

Started Sep 2018

Typical duration for phase_2 gastric-cancer

Geographic Reach
18 countries

189 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 14, 2018

Completed
Same day until next milestone

Study Start

First participant enrolled

September 14, 2018

Completed
19 days until next milestone

First Posted

Study publicly available on registry

October 3, 2018

Completed
2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 23, 2020

Completed
1.6 years until next milestone

Study Completion

Last participant's last visit for all outcomes

May 13, 2022

Completed
11 days until next milestone

Results Posted

Study results publicly available

May 24, 2022

Completed
Last Updated

February 28, 2024

Status Verified

February 1, 2024

Enrollment Period

2 years

First QC Date

September 14, 2018

Results QC Date

April 28, 2022

Last Update Submit

February 23, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Progression-Free Survival (PFS)

    PFS was defined as time from randomization until the date of radiographic disease progression based on investigator assessment using Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 or death from any cause, whichever came first. PFS was analyzed using Kaplan-Meier methods. Participants with no progression or death, or who started new anticancer therapy before documented progression or death without documented progression, or who had ≥ 2 consecutive missing tumor assessments before documented progression or death without documented progression were censored on the date of last adequate tumor assessment. Participants with no baseline tumor assessment, were censored at the date of randomization. The primary efficacy analysis was pre-specified to be conducted after at least 84 PFS events were observed.

    From randomization until the primary analysis data cut-off date of 23 September 2020; median time on follow-up was 10.9 months.

Secondary Outcomes (3)

  • Overall Survival (OS)

    From randomization until the primary analysis data cut-off date of 23 September 2020; median time on follow-up was 10.9 months.

  • Overall Response Rate (ORR)

    Tumor assessments were performed every 8 weeks until 12 months and then every 12 weeks thereafter until disease progression or additional anticancer therapy was initiated; the median duration of follow-up time was 10.9 months.

  • Number of Participants With Treatment-emergent Adverse Events (TEAEs)

    From first dose of study drug to 28 days after last dose of study drug. Actual median (min, max) duration of treatment emergent period was 29 (4.1, 157) weeks in the bemarituzumab + mFOLFOX6 group and 28 (4.3, 133) weeks in the placebo + mFOLFOX6 group.

Study Arms (2)

Bemarituzumab + mFOLFOX6

EXPERIMENTAL

Participants received 15 mg/kg bemarituzumab administered every 2 weeks (Q2W) with a single additional bemarituzumab 7.5 mg/kg dose on cycle 1 day 8. Participants also received mFOLFOX6 chemotherapy administered Q2W. Treatment continued until unacceptable toxicity, disease progression, or death.

Biological: BemarituzumabDrug: Modified FOLFOX6

Placebo + mFOLFOX6

PLACEBO COMPARATOR

Participants received placebo for bemarituzumab administered every 2 weeks with a single additional placebo dose on cycle 1 day 8. Participants also received mFOLFOX6 chemotherapy administered Q2W. Treatment continued until unacceptable toxicity, disease progression, or death.

Drug: PlaceboDrug: Modified FOLFOX6

Interventions

BemarituzumabBIOLOGICAL

Administered by intravenous infusion over approximately 30 minutes

Also known as: FPA144, AMG 552
Bemarituzumab + mFOLFOX6

Administered by intravenous infusion over approximately 30 minutes

Placebo + mFOLFOX6

mFOLFOX6 regimen consists of the following: * Oxaliplatin 85 mg/m² IV infusion over 120 minutes * Leucovorin 400 mg/m² IV infusion over 120 minutes, or 200 mg/m² levo-leucovorin if leucovorin is unavailable * 5-fluorouracil (5-FU) 400 mg/m² bolus over approximately 5 minutes then 5-FU 2400 mg/m² as a continuous IV infusion over approximately 48 hours

Also known as: mFOLFOX6
Bemarituzumab + mFOLFOX6Placebo + mFOLFOX6

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Histologically documented gastric or gastroesophageal junctional adenocarcinoma (not amenable to curative therapy)
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
  • Adequate hematological, liver and kidney function. Measurable or non-measurable, but evaluable disease using RECIST v1.1
  • Fibroblast growth factor receptor 2b (FGFR2b) overexpression as determined by a centrally performed immunohistochemistry tissue test and/or FGFR2 gene amplification as determined by a centrally performed circulating tumor deoxyribonucleic acid (ctDNA) blood based assay
  • Candidate for mFOLFOX6 chemotherapy

You may not qualify if:

  • Untreated or symptomatic central nervous system (CNS) metastases
  • Clinically significant cardiac disease,
  • Peripheral sensory neuropathy \>/= Common Terminology Criteria for Adverse Events (CTCAE) Grade 2
  • Active infection requiring systemic treatment
  • Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)-related illness, or known active or chronic hepatitis B or C infection
  • Prior treatment with any selective inhibitor of the fibroblast growth factor (FGF)-FGFR pathway
  • Known abnormalities of the cornea that may pose an increased risk of developing a corneal ulcer
  • Known positivity for human epidermal growth factor receptor 2 (HER2)
  • Women who are pregnant or breastfeeding

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (189)

University of Arizona Cancer Center

Tucson, Arizona, 85724, United States

Location

The Oncology Institute of Tuscon

Tucson, Arizona, 85745, United States

Location

Marin Cancer Care, Inc-California Cancer Care A Medical Group, Inc

Greenbrae, California, 94904, United States

Location

Sutter Medical Group

Sacramento, California, 95816, United States

Location

UCLA Medical Centre - Santa Monica Hematology and Oncology

Santa Monica, California, 90404, United States

Location

Innovative Clinical Research Institute (ICRI)

Whittier, California, 90603, United States

Location

Yale Cancer Center

New Haven, Connecticut, 06519, United States

Location

Hartford Healthcare Cancer Institute at The Hospital of Central Connecticut

Plainville, Connecticut, 06062, United States

Location

University of Chicago

Chicago, Illinois, 60637, United States

Location

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555, United States

Location

University of Kansas Medical Center

Westwood, Kansas, 66205, United States

Location

Oschsner Clinic Foundation

New Orleans, Louisiana, 70121, United States

Location

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States

Location

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States

Location

University of Michigan Health System

Ann Arbor, Michigan, 48109, United States

Location

Karmanos Cancer Institute

Detroit, Michigan, 48201, United States

Location

Josephine Ford Cancer Center-Henry Ford Cancer Center

Detroit, Michigan, 48202, United States

Location

Summit Medical Group. Morristown Oncology

Morristown, New Jersey, 07960, United States

Location

University of Rochester Medical Center (URMC) - Wilmot Cancer Institute (WCI) (James P. Wilmot Cancer Center)

Rochester, New York, 14642, United States

Location

Stony Brook Cancer Center

Stony Brook, New York, 11794, United States

Location

Westchester Institute For Treatment Of Cancer & Blood Disorders

White Plains, New York, 10601, United States

Location

UNC- Chapel Hill

Chapel Hill, North Carolina, 27599, United States

Location

FirstHealth Outpatient Cancer Center

Pinehurst, North Carolina, 28374, United States

Location

St. Luke's Physician Group - St. Luke's Cancer Care Associates

Bethlehem, Pennsylvania, 18015, United States

Location

Medical University of South Carolina

Charleston, South Carolina, 29435, United States

Location

Tennessee Cancer Specialists

Knoxville, Tennessee, 37909, United States

Location

Arlington Cancer Center

Arlington, Texas, 76012, United States

Location

Utah Cancer Specialists (Intermountain Hematology - Oncology Associates) UCS Cancer Center

South Salt Lake, Utah, 84106, United States

Location

Virginia Mason Seattle Main Clinic

Seattle, Washington, 98101, United States

Location

Chris O'brien Lifehouse

Camperdown, Australia

Location

The Townsville Hospital

Douglas, Australia

Location

Sydney Adventist Hospital

Wahroonga, Australia

Location

AZ Sint Jan

Bruges, Belgium

Location

CH de l'Ardenne

Libramont, 6800, Belgium

Location

CHC Clinique Saint-Joseph

Liège, 04000, Belgium

Location

CHU UCL Namur, site Godinne

Yvoir, 05530, Belgium

Location

Anhui Provincial Cancer Hospital

Hefei, Anhui, 230031, China

Location

Shiyan Taihe Hospital

Shiyan, Hubei, 442000, China

Location

Wuhan Union Hospital of China

Wuhan, Hubei, 430000, China

Location

The 81st Hospital of Chinese PLA

Nanjing, Jiangsu, 210002, China

Location

Beijing Cancer Hospital

Beijing, 100412, China

Location

Chinese PLA General Hospital

Beijing, China

Location

The First Hospital of Jilin University

Changchun, 130021, China

Location

Sino Japanese Friendship Hospital of Jilin University

Changchun, 130033, China

Location

Hunan Cancer Hospital

Changsha, 410006, China

Location

Xiangya Hospital of Central South University

Changsha, China

Location

Chongqing Daping Hospital

Chongqing, 400000, China

Location

Fujian Cancer Hospital

Fuzhou, 350014, China

Location

The First Affiliated Hospital, Zhejiang University

Hangzhou, 310003, China

Location

Sir Run Run Shaw Hospital

Hangzhou, China

Location

Zhejiang Cancer Hospital

Hangzhou, China

Location

Harbin Medical University Cancer Hopsital

Harbin, China

Location

Nanton Tumor Hospital

Nantong, China

Location

Shanghai East Hospital

Shanghai, 200123, China

Location

Fudan University Shanghai Cancer Center

Shanghai, 210032, China

Location

Ruijin Hospital Affiliated to Shanghai Jiatong University School of Medicine

Shanghai, China

Location

Cancer Hospital of Shantou University Medical College

Shantou, 515041, China

Location

Liaoning Cancer Hospital

Shenyang, 110042, China

Location

Fourth Hospital of Hebei Medical University

Shijiazhuang, China

Location

The Second Affiliated Hospital of Soochow University

Suzhou, 215004, China

Location

Tianjin Medical University Cancer Institute and Hospital

Tianjin, 300060, China

Location

Henan Cancer Hospital

Zhengzhou, 450008, China

Location

CHRU Jean MINJOZ

Besançon, 25000, France

Location

Chu Morvan - Institut de Cancerologie

Brest, France

Location

Hopital Nord France Comte - Site Le Mittan

Montbéliard, 25200, France

Location

Polyclinique de Gentilly

Nancy, France

Location

CHU de Saint Etienne

Saint-Etienne, 42055, France

Location

Centre de Radiotherapie - Clinique Sainte Anne

Strasbourg, 67000, France

Location

Centre Paul Strauss

Strasbourg, France

Location

Klinik fur Innere Medizin, Shwerpunkt Gastroenterologie, Hamatologie, Onkologie, Nephrologie

Berlin, 12559, Germany

Location

Stadtisches Klinikum Braunschweig

Braunschweig, 38114, Germany

Location

Krankenhaus Nordwest gGmbH, Institut fur Klinisch-Onkologische Forschung

Frankfurt am Main, 60488, Germany

Location

Klinikum Ludwigsburg

Ludwigsburg, 71640, Germany

Location

Universitatsmedizin Manheim, II. Medizinische Klinik

Mannheim, Germany

Location

Klinikum Ostalb, Stauferklinikum Schwabisch Gmund, Zentrum fur Innere Medizin

Mutlangen, Germany

Location

Kliniken Nordoberpfalz AG, Klinikum Weiden, Medizinische Klinik I

Oberpfalz, 92637, Germany

Location

National Institute of Oncology

Budapest, 1122, Hungary

Location

Del-Pesti Centrumkorhaz - Orszangos Hematologiai es Infektologiai Intezet, Onkologiai Osztaly

Budapest, Hungary

Location

Sugarterapias es Klinikai Onkologaiai Intezet B-A-Z Megyei Korhaz

Miskolc, Hungary

Location

Josa Andras Teaching Hospital

Nyíregyháza, 4400, Hungary

Location

University of Pecs, Clinic of Oncotherapy

Pécs, 7624, Hungary

Location

Jasz-Nagykun-Szolnok Megyei Hetenyi Geza Korhaz - Rendelointezet

Szolnok, 5000, Hungary

Location

AOU Ospedall Riuniti Umberto

Ancona, 60020, Italy

Location

AO "S.G. Moscati"

Avellino, Italy

Location

Centro di Riferimento Oncologico

Aviano, 33081, Italy

Location

Azienda Ospedaliera Spedali Civili di Brescia-Universita degli Studi Di Brescia

Brescia, Italy

Location

Istituto di Ricovero e Cura a Carattere Scientifico - IRCCS di Candiolo

Candiolo, 10060, Italy

Location

Azienda Socio-Sanitaria Territoriale di Cremona

Cremona, 26100, Italy

Location

Azienda Ospedaliero Universitaria Caregg - I S.O.D. Oncologia Medica

Florence, Italy

Location

Ospedale Policlinico S. Martino

Genova, 16132, Italy

Location

Ospedale Generale Mater Salutis" - Azienda ULSS n. 21 di Legnago

Legnago, 37045, Italy

Location

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori

Meldola, 47014, Italy

Location

Istituto Europeo di Oncologia

Milan, 20141, Italy

Location

Servizio Oncologia Medica ed Ematologia, AOU dell'Universita

Napoli, 80131, Italy

Location

Fondazione Irccs Policlinico San Matteo

Pavia, Italy

Location

Azienda Ospedaliera Universitaria Pisana

Pisa, Italy

Location

Policlinico Universitario Campus Bio-Medico di Roma

Roma, Italy

Location

Fondazione IRCSS Casa Sollievo Della Sofferenza

San Giovanni Rotondo, Italy

Location

ASST della Valtellina e dell'Alto Lario - PO di Sondrio

Sondrio, Italy

Location

A.O.U. Citta della Salute e della Scienza di Torino - Presidio Molinette

Torino, Italy

Location

Azienda Sanitaria Universitaria Integrata de Udine

Udine, 33100, Italy

Location

National Cancer Center Hospital East

Kashiwa, Chiba, 277-8577, Japan

Location

Kagawa University Hospital

Kita-gun, Kagawa-ken, 761-0793, Japan

Location

Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

Bunkyō City, Japan

Location

Hiroshima Citizens Hospital

Hiroshima, 730-8518, Japan

Location

St. Marianna University School of Medicine Hospital

Kawasaki, 216-8511, Japan

Location

Japan Community Health Care Organization Kyushu Hospital

Kitakyushu, Japan

Location

The Cancer Institute Hospital of JFCR

Kōtoku, Japan

Location

Niigata Cancer Center Hospital

Niigata, 951-8566, Japan

Location

Hyogo College of Medicine College Hospital

Nishinomiya, 663-8501, Japan

Location

Osaka General Medical Center

Osaka, 558-8558, Japan

Location

Osaka Medical College Hospital

Osaka, 569-8686, Japan

Location

Beskidzkie Centrum Onkologii - Szpital Miejski im. Jana Pawla II w Bielsku-Bialej

Bielsko-Biala, 43-300, Poland

Location

Szpital Specjalistyczny w Brzozowie, Podkarpacki Osrodek Onkologiczny

Brzozów, 36-200, Poland

Location

Samodzielny Publiczny Szpital Kliniczny Nr 1 w Lublinie

Lublin, Poland

Location

SP ZOZ Ministerstwa Spraw Wewnetrznych z Warminsko - Mazurskim Centrum Onkologii

Olsztyn, 10-228, Poland

Location

Europejskie Centrum Zdrowia Otwock Szpital im. F. Chopina

Otwock, 05-400, Poland

Location

Lekarz Beata Madej Mruk I Partner. Spolka Partnerska Oddzial nr 1 w Rzesowie

Rzeszów, 35-021, Poland

Location

Wojskowy Instytut Medyczny, Centralny Szpital Kliniczny Ministerstwa Obronty Narodowej

Warsaw, 04-141, Poland

Location

Centrum Onkologii - Instytut im. Marii Sklodowskiej-Curie Klinika Onkologi I Radioterapii

Warsaw, Poland

Location

Centro Hospitalar do Baixo Vouga, EPE

Aveiro, 3814-501, Portugal

Location

Hospital de Braga

Braga, 4710-243, Portugal

Location

Hospital Senhora Da Oliveira EPE

Guimarães, Portugal

Location

Centro Hospitalar Universitario do Porto E.P.E

Porto, 4099-011, Portugal

Location

Instituto Portugues de Oncologia do Porto Francisco Gentil E.P.E

Porto, Portugal

Location

Centro Hospitalar de Entre o Douro e Vouga EPE

Santa Maria da Feira, Portugal

Location

Unidade Local de Saude de Matosinhos EPE

Senhora da Hora, Portugal

Location

Institutul Clinic Fundeni - Clinica Pediatrie

Bucharest, 022328, Romania

Location

Institutul Oncologic, Prof. Dr. I. Chiricuta Cluj-Napoca

Cluj-Napoca, 400015, Romania

Location

S.C. Medisprof S.R.L

Cluj-Napoca, 400641, Romania

Location

Spitalul Clinic Judetean de Urgenta ,,Sf. Apostol Andrei" Constanta, Clinica Oncologie Medicala

Constanța, 900591, Romania

Location

S.C. Centrul de Oncologie Sf. Nectarie S.R.L., Oncologie Medicala

Craiova, 200347, Romania

Location

SC Oncolab SRL, Oncologie

Craiova, 200385, Romania

Location

S.C. Oncocenter Oncologie Clinica S.R.L

Timișoara, 300166, Romania

Location

Gangnam Severance Hospital, Yonsei University Health System

Seoul, Gangnam, 06273, South Korea

Location

Hallym University Sacred Heart Hospital

Anyang-si, Gyeonggi-do, 14068, South Korea

Location

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea

Location

Ajou University Hospital

Suwon, Gyeonggi-do, 16499, South Korea

Location

Kyungpook National University Chilgok Hospital

Daegu, Gyeongsangbuk-do, South Korea

Location

Chonbuk National University Hospital

Jeonju, Jeollabuk-do, 54907, South Korea

Location

Gachon University Gil Medical Center

Incheon, Namdong-gu, 21565, South Korea

Location

Dong-A University Hospital

Busan, 49201, South Korea

Location

Chungnam National University Hospital (CNUH)

Daejeon, 35015, South Korea

Location

Korea University Anam Hospital

Seoul, 02841, South Korea

Location

Yonsei University Health System

Seoul, 03722, South Korea

Location

Kangbuk Samsung Hospital

Seoul, 04514, South Korea

Location

Asan Medical Center

Seoul, 05505, South Korea

Location

The Catholic University of Korea, Seoul St. Mary's Hospital

Seoul, 06591, South Korea

Location

Korea University Guro Hospital

Seoul, 08308, South Korea

Location

Seoul National University Hospital

Seoul, 3080, South Korea

Location

Complejo Hospitalario Universitario A Coruna

A Coruña, Spain

Location

Hospital Universitario Fundacion Alcorcon

Alcorcón, Spain

Location

Hospital del Mar

Barcelona, 08003, Spain

Location

Hospital Duran I Reynals - Instituto Catalan de Oncologia

Barcelona, 08908, Spain

Location

Hospital de la Santa Creu I Sant Pau

Barcelona, Spain

Location

Hospital General de Catalunya

Barcelona, Spain

Location

Institut Catala d'Oncologia - Hospital Doctor Josep Trueta

Girona, 17007, Spain

Location

Hospital Universitari Arnau de Vilanova

Lleida, Spain

Location

Hospital Universitario Fundacion Jimenez Diaz

Madrid, 28040, Spain

Location

Hospital Universitario HM Sanchinarro

Madrid, 28050, Spain

Location

Hospital General Universitario Gregorio Maranon

Madrid, Spain

Location

Hospital Universitario Puerta de Hierro Majadahonda

Majadahonda, Spain

Location

Clinica Universidad de Navarra

Pamplona, 31008, Spain

Location

Complejo Hospital De Navarra

Pamplona, 31008, Spain

Location

Corporacio Sanitaria Parc Tauli

Sabadell, Spain

Location

Hosptial Universitario Virgen Macarena

Servilla, 41009, Spain

Location

Hospital Universitario Mutua de Terrassa

Terrassa, 08221, Spain

Location

China Medical University Hospital

Taichung, 40447, Taiwan

Location

Faculty of Medicine, Chulalongkorn University

Bangkok, Thailand

Location

Chiangrai Prachanukroh Hospital

Chiang Rai, Thailand

Location

Faculty of Medicine, Prince of Sonkla University

Hat Yai, 90110, Thailand

Location

Khon Kaen Hospital

Khon Kaen, Thailand

Location

Lampang Cancer Hospital

Lampang, Thailand

Location

Cukurova University Faculty of Medicine Paediatric Nephrology

Adana, Turkey (Türkiye)

Location

Hacettepe Universitesi Tip Fakultesi

Ankara, 06100, Turkey (Türkiye)

Location

Ankara Oncology Education and Research Hospital

Ankara, 06200, Turkey (Türkiye)

Location

Ondokuz Mayis University Medicine Faculty

Atakum, 55200, Turkey (Türkiye)

Location

Adnan Menderes Universitesi Uygulama ve Arastirma Hastanesi

Aydin, 09100, Turkey (Türkiye)

Location

Uludag Universitesi Tip Fakultesi

Bursa, 16059, Turkey (Türkiye)

Location

Gaziantep Universitesi Tip Fakultesi, Sahinbey Onkoloji Hastanesi

Gaziantep, Turkey (Türkiye)

Location

Bezmialem Vakif Universitesi Tip Fakultesi Hastanesi

Istanbul, 34093, Turkey (Türkiye)

Location

Istanbul Madeniyet Universitesi Tip Fakultesi

Istanbul, Turkey (Türkiye)

Location

Istanbul University Cerrahpasa Medical Faculty

Istanbul, Turkey (Türkiye)

Location

Medical Park Izmir Hastanesi

Izmir, 35575, Turkey (Türkiye)

Location

Ege University Hopsital

Izmir, Turkey (Türkiye)

Location

Kocaeli Universitesi Tip Fakultesi

Kocaeli, 41380, Turkey (Türkiye)

Location

Inonu Universitesi Tip Fakultesi Turgut Ozal Tip Merkezi

Malatya, 44300, Turkey (Türkiye)

Location

Yuzuncuyil Universitesi Tip Fakultesi

Van, 65080, Turkey (Türkiye)

Location

Ninewells Hospital and Medical School

Dundee, DD198Y, United Kingdom

Location

Related Publications (3)

  • Wainberg ZA, Kang YK, Lee KW, Qin S, Yamaguchi K, Kim IH, Saeed A, Oh SC, Li J, Turk HM, Teixeira A, Hitre E, Udrea AA, Cardellino GG, Sanchez RG, Zahlten-Kumeli A, Taylor K, Enzinger PC. Bemarituzumab as first-line treatment for locally advanced or metastatic gastric/gastroesophageal junction adenocarcinoma: final analysis of the randomized phase 2 FIGHT trial. Gastric Cancer. 2024 May;27(3):558-570. doi: 10.1007/s10120-024-01466-w. Epub 2024 Feb 3.

  • Wainberg ZA, Enzinger PC, Kang YK, Qin S, Yamaguchi K, Kim IH, Saeed A, Oh SC, Li J, Turk HM, Teixeira A, Borg C, Hitre E, Udrea AA, Cardellino GG, Sanchez RG, Collins H, Mitra S, Yang Y, Catenacci DVT, Lee KW. Bemarituzumab in patients with FGFR2b-selected gastric or gastro-oesophageal junction adenocarcinoma (FIGHT): a randomised, double-blind, placebo-controlled, phase 2 study. Lancet Oncol. 2022 Nov;23(11):1430-1440. doi: 10.1016/S1470-2045(22)00603-9. Epub 2022 Oct 14.

  • Xiang H, Liu L, Gao Y, Ahene A, Macal M, Hsu AW, Dreiling L, Collins H. Population pharmacokinetic analysis of phase 1 bemarituzumab data to support phase 2 gastroesophageal adenocarcinoma FIGHT trial. Cancer Chemother Pharmacol. 2020 Nov;86(5):595-606. doi: 10.1007/s00280-020-04139-4. Epub 2020 Sep 23.

MeSH Terms

Conditions

Stomach Neoplasms

Interventions

bemarituzumab

Condition Hierarchy (Ancestors)

Gastrointestinal NeoplasmsDigestive System NeoplasmsNeoplasms by SiteNeoplasmsDigestive System DiseasesGastrointestinal DiseasesStomach Diseases

Results Point of Contact

Title
Study Director
Organization
Amgen

Study Officials

  • MD

    Amgen

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
interventional
Phase
phase 2
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
PARTICIPANT, INVESTIGATOR
Masking Details
Double blinded (participant, treating physician)
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 14, 2018

First Posted

October 3, 2018

Study Start

September 14, 2018

Primary Completion

September 23, 2020

Study Completion

May 13, 2022

Last Updated

February 28, 2024

Results First Posted

May 24, 2022

Record last verified: 2024-02

Data Sharing

IPD Sharing
Will not share

Locations