Fluid Responsiveness Tested by the Effective Pulmonary Blood Flow During a Positive End-expiratory Trial
The Reliability of Noninvasive Effective Pulmonary Blood Flow to Detect Fluid Responsiveness During a Positive End-expirator Trial in Ventilated Patients
1 other identifier
observational
30
1 country
1
Brief Summary
Fluid responsiveness is difficult to assess at the bedside. The accuracy of published techniques to detect preload-dependent patients have many pitfalls and limitations. The present study test the role of noninvasive effective pulmonary blood flow measured by expired carbon dioxide to detect fluid responsivess in mechanically ventilated patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Sep 2018
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 5, 2018
CompletedFirst Submitted
Initial submission to the registry
October 1, 2018
CompletedFirst Posted
Study publicly available on registry
October 3, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
April 12, 2022
CompletedAugust 26, 2022
April 1, 2022
3.6 years
October 1, 2018
August 24, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Fluid responsivess assessment with the effective pulmonary blood flow
Comparison between standard method (pulse pressure variation) with a new method of fluid responsiveness (Effective pulmonary blood flow).
10 months
Study Arms (1)
Patients undergoing surgeries
Patients undergoing surgery with general anesthesia and controlled mechanical ventilation with indication of invasive arterial blood pressure. Classification ASA 2-4
Interventions
Positive end-expiratory pressure (PEEP) is increased from 5 to 10 cmH2O during one minute.
Eligibility Criteria
Cardiac and noncardiac surgery patients ASA 2-4
You may qualify if:
- Written informed consent
- Programmed cardiac and noncardiac surgeries
- Need of invasive arterial blood pressure monitoring.
You may not qualify if:
- Emergency surgeries.
- Acute pulmonary diseases
- Arrhytmias
- Congestive cardiac failure
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hospital Privado de Comunidad
Mar del Plata, Buenos Aires, 7600, Argentina
Related Publications (1)
Tusman G, Groisman I, Maidana GA, Scandurra A, Arca JM, Bohm SH, Suarez-Sipmann F. The Sensitivity and Specificity of Pulmonary Carbon Dioxide Elimination for Noninvasive Assessment of Fluid Responsiveness. Anesth Analg. 2016 May;122(5):1404-11. doi: 10.1213/ANE.0000000000001047.
PMID: 26505574RESULT
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gerardo Tusman, MD
Hospital Privado de Comunidad de Mar del Plata
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
October 1, 2018
First Posted
October 3, 2018
Study Start
September 5, 2018
Primary Completion
April 1, 2022
Study Completion
April 12, 2022
Last Updated
August 26, 2022
Record last verified: 2022-04
Data Sharing
- IPD Sharing
- Will not share