The Impact of Altered Arterioventricular Coupling on Central Cardiovascular Energy Delivery
1 other identifier
observational
41
1 country
1
Brief Summary
This study will assess the amount of energy that the heart will deliver to the central circulation and the efficiency of that energy transfer, in patients undergoing a coronary artery bypass graft operation. Measurements will be taken just after induction of anaesthesia and repeated just after the end of the operation. The total energy delivered by the heart will be calculated by multiplying a pressure curve from the artery in the hand with the instantaneous ultrasound recorded cardiac output flow curve. The energy responsible for the acceleration of the blood volume, known as oscillatory power will also be calculated. The energy transfer will be calculated using a mathematical model based upon other ultrasound and blood pressure recorded variables. We would like to see if any alteration in energy delivered is in part due to impairment in energy transfer or alteration of fraction of oscillatory power rather than a change in total energy production. We would also like to study if there are changes in the oscillatory power after cardiac bypass surgery. The patients will be sampled sequentially into the study. We are not aware of any such studies undertaken in humans previously.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jan 2019
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
August 31, 2018
CompletedFirst Posted
Study publicly available on registry
September 4, 2018
CompletedStudy Start
First participant enrolled
January 2, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 13, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
March 13, 2019
CompletedMarch 21, 2019
March 1, 2019
2 months
August 31, 2018
March 19, 2019
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Arterioventricular coupling
The ratio between arterial elastance and ventricular elastance
1 day
Total Cardiac Power
The amount of energy per second delivered from the left ventricle to the arterial circulation
1 day
Oscillatory Cardiac Power
The part of total cardiac power which is responsible for acceleration of the blood volume during systole.
1 day
Secondary Outcomes (3)
Cardiac Output
1 day
Heart rate
1 day
Systemic vascular resistance
1 day
Eligibility Criteria
The population undergoing elective coronary artery bypass grafting typically have multiple cardiovascular risk factors such as hypertension, hyperlipidaemia, diabetes and smoking.
You may qualify if:
- Elective Coronary Artery Bypass Graft patients
- No contraindications to transoesophageal Echo
- Ejection fraction 40% or over
You may not qualify if:
- Lack of consent
- Emergency operation
- Prosthetic aortic valve
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Norwegian University of Science and Technologylead
- St. Olavs Hospitalcollaborator
Study Sites (1)
St Olavs Hospital
Trondheim, Norway
MeSH Terms
Conditions
Study Officials
- PRINCIPAL INVESTIGATOR
Idar Kirkeby-Garstad, md phd
Norwegian University of Science and Technology
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 31, 2018
First Posted
September 4, 2018
Study Start
January 2, 2019
Primary Completion
March 13, 2019
Study Completion
March 13, 2019
Last Updated
March 21, 2019
Record last verified: 2019-03
Data Sharing
- IPD Sharing
- Will not share