The "Motoric Cognitive Risk" Syndrome in the Canadian Population

NCT03679026 | Active Not Recruiting

• 1 other identifier: CODIM-FLP-16 261
• Study Type: observational
• Target: 1,461
• Locations: 1 country
• Sites: 1

Brief Summary

Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that "motoric cognitive risk" (MCR) syndrome, which has been described in cognitively healthy individuals and combines subjective cognitive complaint with objective slow gait speed, is a pre-dementia syndrome. The uniqueness of "motoric cognitive risk" (MCR)syndrome is that it does not rely on a complex evaluation or laboratory investigations. Thus, it is easy to apply in population-based settings. The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, in the Quebec population using the database of the NuAge study.

Conditions

Cognition Disorders in Old Age; Cardiovascular Diseases; Dementia

Outcome Measures

Primary Outcomes (1)

• Cardio-vascular risk factors and diseases assessed using reported health condition

  medical history

  1 day

Secondary Outcomes (16)

• Cardio-vascular risk factors and diseases assessed using physical examination: BMI

  1 day

• Cardio-vascular risk factors and diseases assessed using physical examination: HW ratio

  1 day

• Cardio-vascular risk factors and diseases assessed using physical examination: blood pressure

  1 day

• Disability and functional limitations

  1 day

• Disability and functional limitations

  1 day

Study Arms (2)

CVRF

individuals with cardio-vascular risk factors and diseases

Other: Summarize of participants' characteristics using means and standard deviations or frequencies and percentages

WCVRF

individuals without cardio-vascular risk factors and diseases

Other: Summarize of participants' characteristics using means and standard deviations or frequencies and percentages

Interventions

Summarize of participants' characteristics using means and standard deviations or frequencies and percentages OTHER

Participants' baseline characteristics will be summarized using means and standard deviations or frequencies and percentages, as appropriate.

CVRF; WCVRF

Eligibility Criteria

• Age: 45 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Individuals eligible for this study will be participants of the comprehensive Canadian Longitudinal Study on Aging (n=30,097). They are separated in four age groups (i.e.; 45-54, 54-64, 65-74 and 75-85). Each group will be divided in two subgroups: individuals with and without cardio-vascular risk factors and diseases.

You may qualify if:

• Individuals eligible for this study will be participants of the NuAge study

You may not qualify if:

• Individuals not eligible for the NuAge study
• dementia
• mobility disability
• no information about cognitive complaint
• no measure of walking speed

Sponsors & Collaborators

• Jewish General Hospital: lead

Study Sites (1)

Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada

Location

MeSH Terms

Conditions

Cardiovascular Diseases; Dementia

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Geriatrics

Study Record Dates

• First Submitted: August 21, 2018
• First Posted: September 20, 2018
• Study Start: August 22, 2017
• Primary Completion: August 21, 2021
• Study Completion: December 21, 2024
• Last Updated: April 5, 2024

Record last verified: 2024-04

Locations

CA (1)