Plasticity of Neonatal Neuronal Networks Temporal Theta Activity, the First Endogenous

NCT03677908 | Completed

• 1 other identifier: PI2017_843_0048
• Study Type: observational
• Target: 28
• Locations: 0 countries
• Sites: N/A

Brief Summary

Temporal theta slow-wave activity (TTA-SW) in premature infants is a specific signature of the early development of temporal networks, as it is observed at the turning point between non-sensory driven spontaneous local processing and cortical network functioning. The role in development and the precise location of TTA-SW remain unknown. Previous studies have demonstrated that preterms from 28 weeks of gestational age (wGA) are able to discriminate phonemes and voice, supporting the idea of a prior genetic structural or activity-dependent fingerprint that would prepare the auditory network to compute auditory information at the onset of thalamocortical connectivity. They recorded TTA-SW in 26-32 wGA preterms. The rate of TTA-SW in response to click stimuli was evalu- ated using low-density EEG in 30 preterms. The sources of TTA-SW were localized by high-density EEG using different tissues conductivities, head models and mathematical models.

Conditions

Premature Birth

Keywords

Temporoparietal Areas; Neural Biomarker

Outcome Measures

Primary Outcomes (1)

• specific temporal TTA-SW

  The objective of this study is to evaluate the spatial organization of the specific Temporal theta slow-wave activity (TTA-SW) with the Low-Density Electroencephalography (LD-EEG) at an early stage of development in humans to demonstrate that TTA-SW were independent of auditory stimuli.

  2 months

Study Arms (2)

13 high

High-Density ElectroEncephaloGraphy analysis of 13 healthy premature infants

Other: ElectroEncephaloGraphy

15 low

Low-Density ElectroEncephaloGraphy analysis of other 15 healthy premature infants

Other: ElectroEncephaloGraphy

Interventions

ElectroEncephaloGraphy OTHER

Density ElectroEncephaloGraphy analysis

13 high; 15 low

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

28 healthy premature infants follow-up between the Gestational Ages of 26 and 32 wGA between December 2014 and June 2015. These infants were divided into two groups accord- ing to age (26-30 wGA and 30-32 wGA).

You may qualify if:

• healthy premature infants
• Gestational Ages of 26 and 32 wGA

You may not qualify if:

• unhealthy premature infants

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

MeSH Terms

Conditions

Premature Birth

Condition Hierarchy (Ancestors)

Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases

Study Officials

• Fabrice Wallois, MD, PhD

  CHU AMIENS

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 14, 2018
• First Posted: September 19, 2018
• Study Start: July 1, 2016
• Primary Completion: January 1, 2017
• Study Completion: January 1, 2017
• Last Updated: September 19, 2018

Record last verified: 2018-09

Data Sharing

• IPD Sharing: Will not share