Study of Circulating Levels of Glicentin

NCT03671928 | Completed

• 1 other identifier: 18-AOI-12
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

Hormones derived from proglucagon represent a family of peptides produced by the alpha cells of the pancreas and by the intestinal L cells. In the pancreas, the maturation of proglucagon mainly leads to the synthesis of glucagon, while in the intestine, the cleavage of proglucagon allows the synthesis of different peptides including glicentine, oxyntomodulin, Glucagon Like Peptide-1 (GLP-1) and Glucagon Like Peptide-2 (GLP-2). Glicentin is produced by L cells throughout the digestive tract, from the small intestine to the rectum, with a majority secretion in the colon. Studies in humans and animals have shown its role in the intestinal mucosa. It has a stimulating effect on the proliferation of the intestinal mucosa as well as an effect on smooth muscle cells and regulates trophicity and intestinal motility. Its circulating rate could be modified in case of intestinal ischemia. Mesenteric ischemia is a major diagnostic problem with high morbidity and mortality, particularly in the event of delayed treatment. The sensitivity and specificity of current markers are low. The identification of new biomarkers of the disease would improve the diagnosis and management of patients with the disease. The objective of the project is to determine a difference in circulating glicentin levels in patients with intestinal ischemia versus a control group. On this prospective monocentric study, 40 patients with digestive ischemia will be included in the Emergency Department of the University Hospital of Nice. A control group of 40 patients with abdominal pain will be formed. The circulating glicentin levels will be measured on serum by Elisa technique at the Biochemistry Laboratory of the University Hospital of Nice, work that has been published in 3 scientific journals allowing us to develop and validate the technique.The staff will determine whether patients with digestive ischemia have impaired serum glicentin levels. The evaluation of the interest of new biological markers of mesenteric ischemia such as glicentine would constitute a definite diagnostic advance. This project could eventually offer new diagnostic and/or therapeutic perspectives in the management of these patients.

Conditions

Ischemia Bowel

Outcome Measures

Primary Outcomes (1)

• difference of at least 20% of the serum glicentin dosage in the "intestinal ischemia" group versus the "control" volunteers.

  glicentine dosage

  24 months

Study Arms (2)

bowel ischemia

OTHER

Other: additional blood tube

non-digestive abdominal pain

OTHER

Other: additional blood tube; Other: additional blood sample

Interventions

additional blood tube OTHER

sampling of an additional tube at the usual blood test to determine the glicentin level

bowel ischemia; non-digestive abdominal pain

additional blood sample OTHER

for le group control, another blood sample is taken outside the usual care.

non-digestive abdominal pain

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• For patients with intestinal ischemia
• The combination of abdominal pain, altered general condition with abdominal defence and venous or arterial hyperlactatemia will be signs suggestive of a diagnosis of digestive ischemia.
• Patients suspected of digestive ischemia with the following comorbidities may be included as clinical suspicion and excluded post-operatively: emboligenic heart disease, arteriopathy, aortic and/or digestive atheromatosis.
• Patients with suspected digestive ischemia and functional scanning ileus.
• Patients with intestinal ischemia proven by CT scan with contrast injection: arterial abnormality such as dissection of an artery for digestive use, thrombosis or embolism of an artery for digestive use; intestinal or colonic thickening suggestive of reversible ischemic suffering of the digestive tract; parietal pneumatosis; gastrointestinal parietal enhancement abnormality (hypo-density ranges or total absence of enhancement).
• The following pathologies will be taken into account: mesenteric ischemia by embolism or thrombosis.
• Age over 18 years old
• Able to understand the study
• Affiliation to a social security system
• Signing of an informed consent
• Accept participation in the study (collection of a Non-Opposition)
• For the control group
• Age over 18 years old
• Able to understand the study
• Affiliation to a social security system

You may not qualify if:

• History of bariatric or digestive surgery (stomach, small intestine, colon or rectum)
• History of chronic inflammatory bowel disease
• Obese patients (BMI\> 30kg/m2)
• History of type 1 diabetes or insulin treatment

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Nice: lead

Study Sites (1)

University Nice Hospital

Nice, 06000, France

Location

Related Publications (1)

• El Hamwi A, Hamard F, Hinault-Boyer C, Raffort J, Lareyre F, Grober J, Massalou D. New Biomarkers of Acute Intestinal Ischemia: A Prospective Study Validating the Interest of Glucagon-Like Peptide-1 and -2. J Am Coll Surg. 2025 Oct 1;241(4):610-618. doi: 10.1097/XCS.0000000000001453. Epub 2025 Sep 16.

  PMID: 40392545 RESULT

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 13, 2018
• First Posted: September 14, 2018
• Study Start: February 3, 2020
• Primary Completion: March 1, 2023
• Study Completion: March 1, 2023
• Last Updated: March 24, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)