Multi-limb Dual-task Control in Parkinson's Disease
Multi-limb Control in Parkinson's Disease: Implicit and Explicit Control of Attention
2 other identifiers
observational
60
1 country
1
Brief Summary
People with Parkinson disease commonly experience difficulty driving, which requires the arms and legs to do different tasks simultaneously. Driving difficulties can lead to isolation, depression, loss of independence and mobility, and increased incidence of car accidents. Through understanding the impact of Parkinson disease on mechanisms underlying attention and multi-limb control, training and rehabilitation programs can better focus on the needs of drivers with Parkinson disease. The proposed study aims to address this need by taking measures of simulated driving at one point in time. Subjects with PD are tested at a single time point when they are at their "best" point in their day and on another day when they are at their worst and are about to take their next dose of medication. Healthy age-matched subjects are not taking anti-parkinson medication so are tested at only one point.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Sep 2017
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2017
CompletedFirst Submitted
Initial submission to the registry
August 30, 2018
CompletedFirst Posted
Study publicly available on registry
September 7, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 30, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
November 30, 2020
CompletedFebruary 7, 2022
February 1, 2022
3.2 years
August 30, 2018
February 4, 2022
Conditions
Outcome Measures
Primary Outcomes (1)
Dual Task Effect on Arm and Foot Tasks
The Dual Task Effect is the performance measure of the arm and foot task, respectively, in the dual task relative to the single task, expressed as a percentage.
Subjects with PD: Two 90-minute sessions within a week; Healthy controls: One 90-minute session, observation of simulated driving.
Study Arms (2)
Parkinson Disease
Observation of individuals with idiopathic Parkinson disease performing a multilimb dual task using the arm and the leg.
Control
Observation of healthy age-matched individuals will perform a multilimb dual task using the arm and the leg.
Interventions
control of arm and foot in two attentional contexts of simulated driving
Eligibility Criteria
Individuals will be recruited through collaboration with hospitals, clinics, physical therapy centers, private practice physicians and physical therapists, neurology-based fitness centers, community centers, PD support groups, online trial-matching services (e.g., FoxTrialFinder.michaeljfox.org), word of mouth, and advertising. Recruitment will be limited to the greater Phoenix metropolitan area.
You may qualify if:
- have a clinical diagnosis of mild to moderate idiopathic PD (Hoehn \& Yahr stages 1-3),
- hold a valid driver's license and drive at least once a week, and
- be capable of providing informed consent and complying with study procedures. Control group participants will be healthy, neurologically intact individuals, age-matched to within 2 years of the PD subjects.
You may not qualify if:
- impaired global cognition (i.e., a score of \< 20 on the Montreal Cognitive Assessment (MoCA) screening tool)
- sensory loss in the lower limb as assessed by clinical test of vibration perception at the ankle,
- orthopedic, visual, or neurological conditions that would prevent performance of the experimental tasks,
- inability to complete and pass the assessment testing,
- history of neurological illness such as head trauma, previous stroke, epilepsy, demyelinating disease, or
- complicating medical problems such as diabetes.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- A.T. Still University of Health Scienceslead
- National Institute of Neurological Disorders and Stroke (NINDS)collaborator
- University of Idahocollaborator
- Mayo Cliniccollaborator
Study Sites (1)
A.T. Still University Arizona School of Health Sciences
Mesa, Arizona, 85206, United States
Related Publications (3)
McIsaac TL, Benjapalakorn B. Allocation of attention and dual-task effects on upper and lower limb task performance in healthy young adults. Exp Brain Res. 2015 Sep;233(9):2607-17. doi: 10.1007/s00221-015-4333-6. Epub 2015 Jun 17.
PMID: 26080755BACKGROUNDMcIsaac TL, Lamberg EM, Muratori LM. Building a framework for a dual task taxonomy. Biomed Res Int. 2015;2015:591475. doi: 10.1155/2015/591475. Epub 2015 Apr 19.
PMID: 25961027BACKGROUNDThompson T, Poulter D, Miles C, Solmi M, Veronese N, Carvalho AF, Stubbs B, Uc EY. Driving impairment and crash risk in Parkinson disease: A systematic review and meta-analysis. Neurology. 2018 Sep 4;91(10):e906-e916. doi: 10.1212/WNL.0000000000006132. Epub 2018 Aug 3.
PMID: 30076275BACKGROUND
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Tara L McIsaac, PhD, PT
A.T. Still University
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
August 30, 2018
First Posted
September 7, 2018
Study Start
September 1, 2017
Primary Completion
November 30, 2020
Study Completion
November 30, 2020
Last Updated
February 7, 2022
Record last verified: 2022-02