Incidence of Pulmonary and Venous Thromboembolism in IVF Pregnancies After Fresh and Frozen Embryo Transfer

NCT03660007 | Completed

• 1 other identifier: Fresh or Frozen IVF
• Study Type: observational
• Target: 902,891
• Locations: 0 countries
• Sites: N/A

Brief Summary

In vitro fertilization (IVF) is associated with an increased risk of venous thromboembolism and in particular pulmonary embolism during the first trimester. It is not known whether this increased risk of pulmonary embolism is present both after fresh and frozen embryo transfer. Objective: To assess whether the risk of pulmonary embolism and venous thromboembolism during the first trimester of IVF pregnancies is associated with both fresh and frozen embryo transfer. A population-based cohort study with linked data from nationwide registries on women in Sweden giving birth to their first child 1992-2012

Conditions

Assisted Reproductive Techniques; Pregnancy; Pulmonary Embolism; Venous Thromboembolism; Fresh Embryo Transfer; Frozen Embryo Transfer

Keywords

In vitro fertilization; Assisted Reproductive Techniques; Pulmonary embolism; Venous Thromboembolism; Pregnancy

Outcome Measures

Primary Outcomes (1)

• First incident pulmonary embolism

  Pulmonary embolism during the period from start of pregnancy until pregnancy day 90

  Estimated start of pregnancy until day 90

Secondary Outcomes (1)

• First incident venous thromboembolism

  Estimated start of pregnancy until day 90

Study Arms (3)

Fresh embryo transfer

This exposure is an IVF pregnancy with fresh embryo transfer performed directly after ovarian stimulation

Procedure: Fresh or frozen embryo transfer IVF

Frozen embryo transfer

This exposure is an IVF pregnancy with frozen embryo transfer, which was thawed and transferred in a later, non-stimulated cycle

Procedure: Fresh or frozen embryo transfer IVF

Natural pregnancy

Spontaneous pregnancy without IVF

Interventions

Fresh or frozen embryo transfer IVF PROCEDURE

Fresh embryo transfer; Frozen embryo transfer

Eligibility Criteria

• Age: 15 Years - 50 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

All Swedish women who had given birth at the age of 15-50 years to a first child from the 1st of January 1992 until the 31st of December 2012 .

You may qualify if:

• Women who had given birth to a first child

You may not qualify if:

• Women with previous pregnancies

Sponsors & Collaborators

• Karolinska Institutet: lead

Related Publications (1)

• Olausson N, Discacciati A, Nyman AI, Lundberg F, Hovatta O, Westerlund E, Wallen HN, Mobarrez F, Bottai M, Ekbom A, Henriksson P. Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilization with fresh respectively frozen-thawed embryo transfer: Nationwide cohort study. J Thromb Haemost. 2020 Aug;18(8):1965-1973. doi: 10.1111/jth.14840. Epub 2020 May 11.

  PMID: 32289205 DERIVED

MeSH Terms

Conditions

Pulmonary Embolism; Venous Thromboembolism

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Thromboembolism

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 10 Months
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 30, 2018
• First Posted: September 6, 2018
• Study Start: January 1, 1992
• Primary Completion: December 31, 2012
• Study Completion: December 31, 2014
• Last Updated: September 6, 2018

Record last verified: 2018-09

Data Sharing

• IPD Sharing: Will not share