Risk of Pulmonary and Venous Thromboembolism in Pregnancies After in Vitro Fertilization

NCT01524393 | Completed

• 1 other identifier: Dnr 2010/267-31/4
• Study Type: observational
• Target: 140,458
• Locations: 1 country
• Sites: 1

Brief Summary

Occurrence of venous thromboembolism during in Vitro Fertilization (IVF) pregnancies has been reported in numerous case reports and in two small consecutive series. The incidence of venous thromboembolism (VTE) after IVF has been claimed to be comparable to the incidence of VTE during normal pregnancy. No information exists concerning pulmonary embolism (PE). The aim is to estimate and compare the risk of both PE and VTE during the the different phases of pregnancy after IVF to that in age and period matched control women. The investigators will use the Swedish National Health Registers to estimate the risk.

Conditions

Pulmonary Embolism; Venous Thromboembolism

Keywords

Assisted Reproductive Techniques; Pregnancy; Pulmonary Embolism; Venous Thromboembolism

Study Arms (1)

IVF pregnancy

Eligibility Criteria

• Sex: female
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All mothers who had given birth to a child.

You may qualify if:

• Exposed women:
• All mothers who had given birth to a child as a result of IVF will be retrieved from the Swedish Medical Birth Register (MBR) at the National Board of Health and Welfare.
• Unexposed women:
• Each IVF woman will be matched with up to 5 unexposed women from the MBR by calendar year of delivery ±2 years and maternal age ±1 year.

Sponsors & Collaborators

• Danderyd Hospital: lead
• Karolinska Institutet: collaborator

Study Sites (1)

Karolinska Institutet

Stockholm, Sweden

Location

Related Publications (3)

• Chan WS, Dixon ME. The "ART" of thromboembolism: a review of assisted reproductive technology and thromboembolic complications. Thromb Res. 2008;121(6):713-26. doi: 10.1016/j.thromres.2007.05.023. Epub 2007 Jul 30.

  PMID: 17659766 BACKGROUND

• Mara M, Koryntova D, Rezabek K, Kapral A, Drbohlav P, Jirsova S, Zivny J. [Thromboembolic complications in patients undergoing in vitro fertilization: retrospective clinical study]. Ceska Gynekol. 2004 Jul;69(4):312-6. Czech.

  PMID: 15369253 BACKGROUND

• Henriksson P, Westerlund E, Wallen H, Brandt L, Hovatta O, Ekbom A. Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study. BMJ. 2013 Jan 15;346:e8632. doi: 10.1136/bmj.e8632.

  PMID: 23321489 DERIVED

MeSH Terms

Conditions

Pulmonary Embolism; Venous Thromboembolism

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Thromboembolism

Study Officials

• Anders Ekbom, Professor

  Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

  STUDY CHAIR

• Peter Henriksson, Professor

  Division of Cardiovascular Medicine, Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden

  PRINCIPAL INVESTIGATOR

• Outi Hovatta, Professor

  Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

  STUDY CHAIR

Study Design

• Study Type: observational
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 28, 2012
• First Posted: February 2, 2012
• Study Start: January 1, 1990
• Primary Completion: December 1, 2008
• Study Completion: December 1, 2010
• Last Updated: February 2, 2012

Record last verified: 2012-01

Locations

SE (1)