Luftibus in the School: a Study on the Respiratory Health of Schoolchildren.

NCT03659838 | Completed

• 1 other identifier: LUIS
• Study Type: observational
• Target: 3,500
• Locations: 1 country
• Sites: 1

Brief Summary

This study assessed the respiratory health of schoolchildren from the canton of Zurich by combining self-reported information on respiratory symptoms with lung function test results and air pollution measurements. Luftibus in the school (LUIS) is a population-based study conducted in the canton of Zurich, Switzerland. Between the years 2013 and 2016 a bus with equipment for lung function testing and air pollution measurement visited numerous schools across the canton Zurich. The parents of the schoolchildren filled in a questionnaire with validated questions on upper and lower respiratory symptoms, trigger factors, diagnosis, treatment of respiratory symptoms, health behavior and environmental factors. The children were interviewed using a shorter questionnaire. Fieldworkers measured lung function (spirometry and double tracer gas single-breath washout) and an airway inflammation test (fractional exhaled nitric oxide) in the bus. The recruited population included 3500 schoolchildren aged 6 to 16 years from the canton of Zurich. Respiratory symptoms and their influence on physical activity and sleep have a strong impact on children's quality of life and school performance. The results of this study will provide new insights on schoolchildren's respiratory health that may help to establish new recommendations and influence policy makers' decisions.

Conditions

Respiratory Disease

Keywords

Asthma; Wheeze; Cough; Snoring; Bronchial obstruction; Air pollution

Outcome Measures

Primary Outcomes (6)

• Parent-reported respiratory symptoms

  Prevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using parent questionnaires.

  At baseline

• Self-reported respiratory symptoms

  Prevalence of upper and lower respiratory tract symptoms including wheeze, cough, rhinitis and snoring, reported using participant questionnaires.

  At baseline

• Lung function measurements: Spirometry, forced expiratory volume in 1 second z-scores

  Forced expiratory volume in 1 second (FEV1) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.

  At baseline

• Lung function measurements: Spirometry, forced vital capacity z-scores

  Forced vital capacity (FVC) z-scores calculated based on Global Lung Function Initiative (GLI) reference values.

  At baseline

• Lung function measurements: Single-breath washout

  Slope from the tidal (alveolar) phase III (SIII) from double-tracer gas single-breath washout test curves.

  At baseline

• Airway inflammation

  Airway inflammation measured by levels of fractional concentration of exhaled nitric oxide.

  At baseline

Secondary Outcomes (6)

• Parent-reported respiratory symptoms

  One year after baseline

• Self-reported respiratory symptoms

  One year after baseline

• Lung function measurements: Spirometry, forced expiratory volume in 1 second z-scores

  One year after baseline

• Lung function measurements: Spirometry, forced vital capacity z-scores

  One year after baseline

• Lung function measurements: Single-breath washout

  One year after baseline

Study Arms (1)

Participants

Schoolchildren from the canton of Zürich aged 6 to 16 years

Eligibility Criteria

• Age: 6 Years - 16 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Community sample of schoolchildren from the canton of Zürich

You may qualify if:

• Schoolchildren living in the canton of Zürich
• Age range 6 to 16 years
• Parental consent to participate

Sponsors & Collaborators

• University Children's Hospital, Zurich: lead
• University of Bern: collaborator

Study Sites (1)

University Children's Hospital Zürich

Zurich, 8032, Switzerland

Location

Related Publications (1)

• Kentgens AC, Kurz JM, Mozun R, Usemann J, Pedersen ESL, Kuehni CE, Latzin P, Moeller A, Singer F; LuftiBus In the School (LUIS) Study Group. Evaluation of the Double-Tracer Gas Single-Breath Washout Test in a Pediatric Field Study. Chest. 2024 Feb;165(2):396-404. doi: 10.1016/j.chest.2023.09.006. Epub 2023 Sep 15.

  PMID: 37716474 DERIVED

MeSH Terms

Conditions

Respiration Disorders; Asthma; Respiratory Sounds; Cough; Snoring

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Bronchial Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Alexander Möller, PD Dr.med

  University Children's Hospital, Zurich

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2018
• First Posted: September 6, 2018
• Study Start: November 28, 2013
• Primary Completion: December 15, 2016
• Study Completion: December 15, 2016
• Last Updated: September 6, 2018

Record last verified: 2018-08

Data Sharing

• IPD Sharing: Will share

Locations

CH (1)