Surface Respiratory Electromyography Measurements During Treadmill Exercise in Stable Patients With COPD

NCT03238209 | Completed

• 1 other identifier: GuangzhouInsReD
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

To evaluate the compatibility and correlation between noninvasive surface respiratory electromyography and invasive transesophageal diaphragmatic electromyography measurements, as facilitating indicators of neural respiratory drive evaluation during treadmill exercise. Transesophageal diaphragmatic EMG (EMGdi,es) and surface inspiratory EMG, including surface diaphragmatic EMG (EMGdi,sur), surface parasternal intercostal muscle EMG (EMGpara) and surface sternocleidomastoid EMG (EMGsc) were detected simultaneously during increasing capacity exercise in stable patients with COPD. EMGdi,es, EMGdi,sur, EMGpara and EMGsc was quantified using root mean square (RMS), which represent as RMSdi,es, RMSdi,sur, RMSpara and RMSsc.

Conditions

Respiratory Disease

Keywords

neural respiratory drive; transesophageal diaphragmatic EMG; surface diaphragmatic EMG; surface sternocleidomastoid EMG; surface parasternal intercostal muscle EMG

Outcome Measures

Primary Outcomes (1)

• transesophageal diaphragmatic EMG

  transesophageal diaphragmatic EMG was measured using a multipair esophageal electrode consisting of nine consecutive coils composed of five electrode pairs positioned in the esophagus and traversing the cardia

  30 minute

Secondary Outcomes (3)

• Surface diaphragmatic EMG

  30 minute

• Surface parasternal EMG

  30 minute

• Surface sternocleidomastoid EMG

  30 minute

Study Arms (1)

Exercise testing

EXPERIMENTAL

The test consisted of a steady-state resting period of 3 min followed by 1 min of unloaded pedaling at 60 cycles/min for each individual; the exercise load was increased by 10 W each min until the test had to be stopped because symptoms prevented further exercise. After test results were recorded, EMGdi,es and each surface inspiratory EMG of maximal exercise capacity were analysed.

Diagnostic Test: Exercise testing

Interventions

Exercise testing DIAGNOSTIC_TEST

The test consisted of a steady-state resting period of 3 min followed by 1 min of unloaded pedaling at 60 cycles/min for each individual; the exercise load was increased by 10 W each min until the test had to be stopped because symptoms prevented further exercise. After test results were recorded, EMGdi,es and each surface inspiratory EMG of maximal exercise capacity were analysed.

Exercise testing

Eligibility Criteria

• Age: 40 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• post bronchodilator forced expiratory volume in 1 s \[FEV1\]/forced vital capacity \[FVC\] ,70% and FEV1 ,50% of the predicted value);
• bronchial dilation test (BDT) negative.

You may not qualify if:

• acute exacerbation in the previous 4 weeks;
• use of oral corticosteroids within 4 weeks;
• smoking more than 10 cigarettes daily;
• history of other respiratory, cardiovascular, neuromuscular, and musculoskeletal diseases that could interfere with the exercise performance and inspiratory muscle activities.

Sponsors & Collaborators

• Guangzhou Institute of Respiratory Disease: lead

MeSH Terms

Conditions

Respiration Disorders

Interventions

Exercise Test

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Heart Function Tests; Diagnostic Techniques, Cardiovascular; Diagnostic Techniques and Procedures; Diagnosis; Respiratory Function Tests; Diagnostic Techniques, Respiratory System; Ergometry; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: August 1, 2017
• First Posted: August 3, 2017
• Study Start: July 1, 2016
• Primary Completion: December 15, 2016
• Study Completion: December 30, 2016
• Last Updated: August 3, 2017

Record last verified: 2017-08