NCT03654235

Brief Summary

This study evaluates the effects of a pain neuroscience education (PNE) and physical exercise (PE) program in patients with chronic back pain. Half of participants receive PNE and PE program supervised by a physiotherapist and the other half receive usual physiotherapy care supported by physiotherapy protocols in primary care.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
170

participants targeted

Target at P75+ for not_applicable chronic-pain

Timeline
Completed

Started Feb 2017

Longer than P75 for not_applicable chronic-pain

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

February 1, 2017

Completed
1.6 years until next milestone

First Submitted

Initial submission to the registry

August 24, 2018

Completed
7 days until next milestone

First Posted

Study publicly available on registry

August 31, 2018

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2020

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

December 30, 2020

Completed
Last Updated

February 21, 2020

Status Verified

February 1, 2020

Enrollment Period

3.8 years

First QC Date

August 24, 2018

Last Update Submit

February 19, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change in Health-related Quality of Life at different time points

    Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) V2. Spanish version. The SF-36 is a 36-item scale constructed to survey health status and quality of life. It yields an 8-scale profile of functional health and well-being scores as well as psychometrically-based physical and mental health summary. Each scale is directly transformed into a 0-100 scale. Higher scores indicate better overall quality of life.

    Change from baseline to post-treatment, to 6 months and at 12 months follow-up

Secondary Outcomes (9)

  • Change in Pain assessment at different time points

    Change from baseline to post-treatment, to 6 months and at 12 months follow-up

  • Pressure pain threshold.

    Change from baseline to post-treatment, to 6 months and at 12 months follow-up

  • Change in Pain Catastrophism at different time points

    Change from baseline to post-treatment, to 6 months and at 12 months follow-up

  • Change in Kinesiophobia at different time points

    Change from baseline to post-treatment, to 6 months and at 12 months follow-up

  • Change in Disability at different time points

    Change from baseline to post-treatment, to 6 months and at 12 months follow-up

  • +4 more secondary outcomes

Study Arms (2)

PNE and PE program

EXPERIMENTAL

Pain neuroscience education (Health education) and Physical exercise program.

Other: Health EducationOther: Physical exercise

Usual care in Primary Care Physiotherapy

ACTIVE COMPARATOR

Usual care in Primary Care Physiotherapy Units

Other: Usual care in Primary Care Physiotherapy Units

Interventions

6 pain neuroscience education sessions (10 hours) and delivery of printed reinforcement material.

PNE and PE program

Group physical exercise program (18 sessions; 3 sessions/week) leaded by a physiotherapist. It includes exercises to improve strength, coordination, balance and aerobic capacity. Work with double tasks, recreational activities to overcome kinesiophobia and activities to do at home are used in the program.

PNE and PE program

Treatment supported by the protocol of primary care of physiotherapy in the health service of Castilla y León that was in force at the time of the intervention. Patients receive 15 sessions of analgesic electrotherapy, thermotherapy and standardized physical exercise

Usual care in Primary Care Physiotherapy

Eligibility Criteria

Age18 Years - 70 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Nonspecific back pain of at least 6 months.
  • Accept to participate in the study and sign the informed consent.

You may not qualify if:

  • Oncological pain.
  • Spine fracture or surgical intervention in last year.
  • Neurological cognitive alteration that prevents understanding the contents of PNE program (In case of doubt, assesment with Minimental test)
  • Motor control alteration that prevents the execution of the planned PE program (Minimum requirement: execution in normal time of the Timed Up and Go test)
  • Pregnancy.
  • Bladder or bowel incontinence.
  • Saddle anesthesia.
  • Patients presenting other clinical conditions that may aggravate chronic spinal pain (chronic fatigue syndrome, fibromyalgia and complex regional pain syndrome).
  • Patients with associated pathologies that make it impossible to perform physical exercise program.
  • Patients under treatment with alternative therapies.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Unidad de estrategias de Afrontamiento Activo para el dolor. Sacyl

Valladolid, 47011, Spain

RECRUITING

Related Publications (1)

  • Galan-Martin MA, Montero-Cuadrado F, Lluch-Girbes E, Coca-Lopez MC, Mayo-Iscar A, Cuesta-Vargas A. Pain neuroscience education and physical exercise for patients with chronic spinal pain in primary healthcare: a randomised trial protocol. BMC Musculoskelet Disord. 2019 Nov 3;20(1):505. doi: 10.1186/s12891-019-2889-1.

MeSH Terms

Conditions

Chronic PainMusculoskeletal PainBack Pain

Interventions

Exercise

Condition Hierarchy (Ancestors)

PainNeurologic ManifestationsSigns and SymptomsPathological Conditions, Signs and SymptomsMuscular DiseasesMusculoskeletal Diseases

Intervention Hierarchy (Ancestors)

Motor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Miguel A. Galán Martín

    Castilla-León Health Service

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Federico Montero Cuadrado

CONTACT

Miguel Á. Galán Martín

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Masking Details
Patients Evaluator and Outcomes Assessor are masked
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 24, 2018

First Posted

August 31, 2018

Study Start

February 1, 2017

Primary Completion

November 30, 2020

Study Completion

December 30, 2020

Last Updated

February 21, 2020

Record last verified: 2020-02

Data Sharing

IPD Sharing
Will not share

Locations