White Matter Integrity According to BDNF Genotype After Stroke
Changes of White Matter Integrity According to BDNF Genotype During Motor Recovery After Stroke
1 other identifier
observational
58
1 country
1
Brief Summary
The aim of this study was to investigate differential plastic changes of fractional anisotropy (FA) in the corticospinal tract (CST), the intrahemispheric corticocortical tract from the primary motor cortex to ventral premotor cortex (M1PMv) and the corpus callosum (CC) from 2 weeks to 3 months after stroke according to BDNF genotype.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started May 2018
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 25, 2018
CompletedFirst Submitted
Initial submission to the registry
August 22, 2018
CompletedFirst Posted
Study publicly available on registry
August 27, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 5, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
April 5, 2019
CompletedSeptember 19, 2019
September 1, 2018
11 months
August 22, 2018
September 18, 2019
Conditions
Outcome Measures
Primary Outcomes (1)
Fractional anisotropy
changes of fractional anisotropy (FA) in the corticospinal tract (CST)
2 weeks to 3 months after stroke onset
Secondary Outcomes (2)
Fractional anisotropy
2 weeks to 3 months after stroke onset
Fractional anisotropy
2 weeks to 3 months after stroke onset
Interventions
This study is a longitudinal observational study
Eligibility Criteria
Patients with ischemic stroke who were admitted to Samsung Medical Center and transferred to the Department of Physical and Rehabilitation Medicine
You may qualify if:
- diagnosed with first-ever hemispheric ischemic infarction with damage to the supratentorial area confirmed by brain MRI within 2 weeks after stroke onset
You may not qualify if:
- any clinically significant or unstable medical disorder or neuropsychiatric comorbidity
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Samsung Medical Center
Seoul, Gangnam-gu, 06351, South Korea
Related Publications (1)
Park E, Lee J, Chang WH, Lee A, Hummel FC, Kim YH. Differential Relationship between Microstructural Integrity in White Matter Tracts and Motor Recovery following Stroke Based on Brain-Derived Neurotrophic Factor Genotype. Neural Plast. 2020 Sep 22;2020:5742421. doi: 10.1155/2020/5742421. eCollection 2020.
PMID: 33029116DERIVED
Biospecimen
brain-derived neurotrophic factor (BDNF) genotype single nucleotide polymorphism (SNP): a methionine (Met) substitution for valine (Val) at codon 66 (Val66Met; rs6265)
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
August 22, 2018
First Posted
August 27, 2018
Study Start
May 25, 2018
Primary Completion
April 5, 2019
Study Completion
April 5, 2019
Last Updated
September 19, 2019
Record last verified: 2018-09