Cognitive Training in Stroke Patients
Neural Correlates and Functional Connectivity Associated With Cognitive Memory Training in Patients With Cerebral Ischemic Lesions
1 other identifier
interventional
30
1 country
1
Brief Summary
The study aims to investigate the behavioral effects, neural correlates and functional connectivity of cognitive training in patients with stroke
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Jan 2015
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 2, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
February 1, 2018
CompletedFirst Submitted
Initial submission to the registry
August 16, 2018
CompletedFirst Posted
Study publicly available on registry
August 23, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2023
CompletedNovember 28, 2023
November 1, 2023
3.1 years
August 16, 2018
November 25, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change from baseline memory performance at 6 months
Hopkins Verbal Learning Test (episodic memory test total immediate score 48 and delayed score12) and fMRI active task (news recall immediate and delayed score 12)
up to 24 weeks after intervention
Secondary Outcomes (1)
Change from baseline everyday life activity performance at 6 months
up to 24 weeks of intervention
Study Arms (2)
Cognitive training
EXPERIMENTALSemantic categorization training sessions
Control condition
ACTIVE COMPARATORFive sessions of behavioral control condition with information and education
Interventions
Five sessions of semantic strategy training and face-name association training
Five sessions of active control information and education
Eligibility Criteria
You may qualify if:
- people with chronic vascular ischemic lesions (more than 6 months)
You may not qualify if:
- vascular hemorrhages, stenosis, psychiatric problems
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- São Paulo State Universitylead
- University of Sao Paulocollaborator
Study Sites (1)
University of Sao Paulo
São Paulo, São Paulo, 05403000, Brazil
Related Publications (2)
Gibson E, Koh CL, Eames S, Bennett S, Scott AM, Hoffmann TC. Occupational therapy for cognitive impairment in stroke patients. Cochrane Database Syst Rev. 2022 Mar 29;3(3):CD006430. doi: 10.1002/14651858.CD006430.pub3.
PMID: 35349186DERIVEDMiotto EC, Bazan PR, Batista AX, Conforto AB, Figueiredo EG, Martin MDGM, Avolio IB, Amaro E Jr, Teixeira MJ. Behavioral and Neural Correlates of Cognitive Training and Transfer Effects in Stroke Patients. Front Neurol. 2020 Sep 15;11:1048. doi: 10.3389/fneur.2020.01048. eCollection 2020.
PMID: 33041987DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Eliane C Miotto, PhD
University of Sao Paulo
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal investigator
Study Record Dates
First Submitted
August 16, 2018
First Posted
August 23, 2018
Study Start
January 2, 2015
Primary Completion
February 1, 2018
Study Completion
December 31, 2023
Last Updated
November 28, 2023
Record last verified: 2023-11
Data Sharing
- IPD Sharing
- Will not share