Analysis of the Sweat Response According to the Pathology in Neurologic Patients

NCT03639909 | Completed

• 1 other identifier: RC31/15/7550
• Study Type: observational
• Target: 450
• Locations: 0 countries
• Sites: N/A

Brief Summary

Cardiovascular autonomic neuropathy (CAN) has been shown to be an important risk factor for cardiac diseases, particularly in diabetes. CAN may be investigated by a battery of laboratory cardiovascular autonomic reflex tests(initially described by Ewing). First screening for CAN (as proposed in diabetic patients) can be performed by assessing heart rate (HR) response to deep breathing, blood pressure (BP) and HR response to a 5 minutes stand test

Conditions

Neurological Disorder

Keywords

sweat gland

Outcome Measures

Primary Outcomes (1)

• Sweating autonomic test

  Evaluate the performance of the laboratory battery of CV tests and of sweating dysfunction to differentiate MSA-P from PD

  baseline

Study Arms (2)

MSA-P

Patients with multiple systeme atrophy (MSA) with predominant parkinsonism (MSA-P) had evaluation of cardiovascular function and sweating function

Procedure: sweating function; Procedure: Cardiovascular function

PD patients

Parkinson's disease (PD) patients had evaluation of cardiovascular function and sweating function

Procedure: sweating function; Procedure: Cardiovascular function

Interventions

sweating function PROCEDURE

Sweating dysfunction by Sudoscan

Also known as: sweating dysfunction by Sudoscan

MSA-P; PD patients

Cardiovascular function PROCEDURE

Cardiovascular (CV) tests

MSA-P; PD patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients referred to the autonomic laboratory of the neurology department at Toulouse University Hospital

You may qualify if:

• Patients with MSA-P or PD

Sponsors & Collaborators

• University Hospital, Toulouse: lead

MeSH Terms

Conditions

Nervous System Diseases

Interventions

Sweating; Cardiovascular Physiological Phenomena

Intervention Hierarchy (Ancestors)

Body Temperature Regulation; Body Temperature; Physiological Phenomena; Homeostasis; Skin Physiological Phenomena; Integumentary System Physiological Phenomena; Adaptation, Physiological; Adaptation, Biological; Biological Phenomena; Circulatory and Respiratory Physiological Phenomena

Study Officials

• Anne Pavy-Le Traon, MD

  University Hospital, Toulouse

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 17, 2018
• First Posted: August 21, 2018
• Study Start: March 1, 2015
• Primary Completion: March 1, 2017
• Study Completion: March 1, 2017
• Last Updated: August 21, 2018

Record last verified: 2018-08

Data Sharing

• IPD Sharing: Will not share