NCT03622632

Brief Summary

The goal of this project, is to better understand the fluctuation of the level of uric acid in traumatized patients by making serial measurements during their hospitalization in the intensive care unit. In addition, the determinants (e.g. type of trauma, diseases, interventions) of the blood level of uric acid and its association with the development of organ failure will be sought.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
25

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Sep 2018

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 24, 2018

Completed
16 days until next milestone

First Posted

Study publicly available on registry

August 9, 2018

Completed
2 months until next milestone

Study Start

First participant enrolled

September 30, 2018

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2020

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2020

Completed
Last Updated

February 18, 2020

Status Verified

February 1, 2020

Enrollment Period

1.8 years

First QC Date

July 24, 2018

Last Update Submit

February 16, 2020

Conditions

TraumaInflammation

Keywords

uric acidorgan failure

Outcome Measures

Primary Outcomes (1)

  • Feasibility of serial plasmatic uric acid sampling after trauma

    Number of measures collected/number of measures planned

    7 days

Secondary Outcomes (2)

  • Impact of resuscitation on uric acid measures

    24 to 48 hours

  • Clinical predictors of the first blood uric acid (μmol/L) level measured

    12 hours

Eligibility Criteria

Age18 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Multiple trauma patients admitted in the trauma center and requiring ICU admission.

You may qualify if:

  • Direct admission to trauma center
  • ≤ 3h after trauma
  • ISS ≥ 16
  • Received at least 1L of fluid at ER entrance

You may not qualify if:

  • Isolated head injury
  • Isolated spine injury
  • Chemotherapy within the last month
  • Hematologic disease
  • Chronic hemodialysis
  • Uricase treatment within the last week
  • Expected death within 48h

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Hôpital du Sacré-Cœur de Montréal

Montreal, Quebec, H4J1C5, Canada

Location

MeSH Terms

Conditions

Wounds and InjuriesInflammation

Condition Hierarchy (Ancestors)

Pathologic ProcessesPathological Conditions, Signs and Symptoms

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD PhD

Study Record Dates

First Submitted

July 24, 2018

First Posted

August 9, 2018

Study Start

September 30, 2018

Primary Completion

August 1, 2020

Study Completion

September 1, 2020

Last Updated

February 18, 2020

Record last verified: 2020-02

Locations

CA(1)