Effect of Early Antiviral Therapy on Duration of Cough in Flu Patients

NCT03618407 | Unknown

• 1 other identifier: HuKe
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

This study mainly focused on the effect of early antiviral treatment on the duration of cough in influenza patients.investigators conducted an early investigation of patients with positive influenza virus and asked whether patients used antiviral drugs in the early stages. According to the use of drugs, patients were divided into oral oseltamivir group, oral lotus phlegm group and other groups, and investigators will collected Inspection information and medication status,during the treatment period of patients.

Conditions

Influenza Virus Infection

Keywords

Influenza; Antiviral Treatment; Cough; Oseltamivir capsule; Lotus Clear Capsule

Outcome Measures

Primary Outcomes (1)

• Cough duration

  Investigators will follow up every other week for follow-up calls or outpatients to ask about cough and medication, until the patient stops coughing, cough lasts from 1 day to 12 weeks, and cough time is greater than 12 weeks. Investigators should seriously exclude cough caused by other factors. No other factors are still included in the study, and the maximum time is no more than 6 months. If there are other factors causing cough, it will not be included in the study.

  6 months

Study Arms (3)

Oral oseltamivir group

Patients with influenza virus positive and early oral oseltamivir capsules

Oral Lotus Capsules group

Patients with positive influenza virus and early oral administration of lotus extract capsules

other group

Influenza virus positive patients who were not treated with oral lotus capsule or oseltamivir capsules early

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Flu patients who were diagnosed in our hospital from April 2018 to July 2019

You may qualify if:

• For patients with flu-free flu, cough for at least one week.
• In line with the flu etiological diagnostic criteria: According to the guidelines set by the National Health and Health Committee, the diagnosis is based on etiological screening methods or confirmed methods; ages 18 to 70 years.
• There are no influenza complications such as acute lower respiratory tract infection, tonsillitis, sinusitis, otitis media, myocarditis, etc.
• It is usually healthy and there are no chronic underlying diseases such as hypertension and diabetes.
• Treating with cough as the main symptom, the cough lasts for at least one week and the chest radiograph is normal.
• Signed informed consent.

You may not qualify if:

• Suspected flu patients who have not received the flu etiology test;
• There is a clear comorbid disease (combined with other sites of acute bacterial or viral infections);
• There is a clear cough caused by other reasons;
• With severe liver and kidney dysfunction;
• Pregnant women.

Sponsors & Collaborators

• Renmin Hospital of Wuhan University: lead

Study Sites (1)

Renmin Hospital of Wuhan University

Wuhan, Hubei, 430060, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood samples Saliva samples Sputum samples

MeSH Terms

Conditions

Influenza, Human; Cough

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Orthomyxoviridae Infections; RNA Virus Infections; Virus Diseases; Respiratory Tract Diseases; Respiration Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Respiratory and Critical Care Medicine II

Study Record Dates

• First Submitted: July 4, 2018
• First Posted: August 7, 2018
• Study Start: September 1, 2018
• Primary Completion: September 1, 2019
• Study Completion: December 1, 2019
• Last Updated: August 7, 2018

Record last verified: 2018-07

Locations

CN (1)