Ankle Brachial Index Combined With Serum Uric Acid Levels Improve Prediction All Cause Mortality and Cardiovascular Mortality in the Elderly Chinese Population

NCT03616418 | Completed

• 1 other identifier: abilities
• Study Type: observational
• Target: 3,026
• Locations: 0 countries
• Sites: N/A

Brief Summary

Peripheral arterial disease (PAD) is a common clinical manifestation of the systemic atherosclerotic process, and the ankle brachial index (ABI) is an ideal tool to diagnose PAD. The association between high serum uric acid levels (SUA) and arterial stiffness as well as endothelial dysfunction has been demonstrated in humans and uric acid has been suggested to be an important modulator of the inflammatory process. It has also been confirmed by clinical studies. Currently, there have been few long term follow up studies focused on the whether serum uric acid levels combined with ankle brachial index can improve prediction all cause mortality and cardiovascular mortality,especially in China population.Therefore, the aim of this study was to elucidate whether ABIcombined with SUA can improve prediction all cause mortality and cardiovascular mortality in the elderly China population independently of the traditional Framingham Risk Score.

Conditions

Ankle Brachial Index

Keywords

ankle brachial index; cardiovascular disease; risk factors; Framingham Cardiovascular Risk Score; uric acid; survival analysis

Outcome Measures

Primary Outcomes (1)

• all cause mortality and cardiovascular mortality

  Cardiovascular events definitions: Hospitalized myocardial infarction was classified as definite or probable based on chest pain symptoms, cardiac enzyme levels, and electrocardiographic findings, or angioplasty28. Coronary heart disease was determined to be present if there was (1) electrocardiographic (ECG) evidence of a prior myocardial infarction, (2) prior coronary artery bypass surgery or angioplasty, (3) Coronary angiography show coronary heart disease, (4) have symptoms of angina and ECG revealed myocardial ischemia performance or laboratory tests showed cardiac enzymes increased and exclude other types of disease, (5) a self-reported history of a physician-diagnosed heart attack 29. CHD death was classified "definite" based on chest pain symptoms, hospital records, and medical history.

  From August 2018 to August 2020

Interventions

antiplatelet drugs;statins;antihypertensive drugs DRUG

Also known as: According to the international guidelines, we treated patients who suffered from different disease.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

subjects aged over 65 years old, living in communities located in the Shanghai, will be invited to participate in the present study, if they are willing to give their written informed consents.

You may qualify if:

• age≥65 years old
• Shanghai residents
• Sign informed consent

You may not qualify if:

• serious heart disease (NYHA\>IV) or end stage renal disease (CKD \> 4)
• cancer and life expectancy was less than 5 years
• Severe congestive heart failure and Severe renal failure patients
• Participants had other diseases that required withdrawal from the clinical trial
• Patients are reluctant to participate in clinical research
• The patient violated the experimental protocol
• Clinical diagnosis of Alzheimer's Disease

Sponsors & Collaborators

• Shanghai 10th People's Hospital: lead

MeSH Terms

Conditions

Cardiovascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: cardiology department of shanghai 10th people's hospital

Study Record Dates

• First Submitted: July 31, 2018
• First Posted: August 6, 2018
• Study Start: January 1, 2017
• Primary Completion: August 1, 2019
• Study Completion: August 1, 2021
• Last Updated: December 29, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share