Effects of Hookah (Waterpipe) Smoking on Blood Vessel Function

NCT03616002 | Terminated

• 1 other identifier: Pro00036547
• Study Type: interventional
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to assess the acute effects of Hookah (waterpipe) smoking on blood vessel function. Hookah smoking has been shown to immediately increase blood pressure and heart rate which could result in damage in the inner lining of the body's blood vessels.

Conditions

Hookah Smoking

Outcome Measures

Primary Outcomes (1)

• Brachial artery flow-mediated dilation

  change from baseline to immediately after smoking

Secondary Outcomes (1)

• Reactive hyperemia peripheral arterial tonometry

  change from baseline to immediately after smoking

Other Outcomes (2)

• Pulse wave velocity

  change from baseline to immediately after smoking

• aortic pressure waveform

  change from baseline to immediately after smoking

Study Arms (1)

Hookah smoking

EXPERIMENTAL

Healthy habitual Hookah smokers will undergo brachial artery flow mediated dilation, reactive hyperemia peripheral arterial tonometry or pulse tonometry before and after Hookah smoking.

Other: Hookah smoking

Interventions

Hookah smoking OTHER

ad lib hookah smoking for 30 minutes in a controlled laboratory environment.

Hookah smoking

Eligibility Criteria

• Age: 18 Years - 29 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• to 29 years of age
• Habitual Hookah smoker defined as having smoked Hookah \>=12 times in the past 12 months
• Have not smoked cigarettes within the past 12 months

You may not qualify if:

• History of cardiopulmonary, diabetes, dyslipidemia or psychiatric disease
• Exhaled carbon monoxide level \>10 ppm
• BP \< 140/90 mmHg
• BMI \<18.5 or \> 30 kg•m2
• Resting heart rate \> 100 beats/min
• Taking prescription medication
• History of illicit drug use
• Pregnant

Sponsors & Collaborators

• Cedars-Sinai Medical Center: lead
• University of California, Los Angeles: collaborator
• University of California, San Francisco: collaborator

Study Sites (1)

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

Location

Related Publications (1)

• Rezk-Hanna M, Mosenifar Z, Benowitz NL, Rader F, Rashid M, Davoren K, Moy NB, Doering L, Robbins W, Sarna L, Li N, Chang LC, Elashoff RM, Victor RG. High Carbon Monoxide Levels from Charcoal Combustion Mask Acute Endothelial Dysfunction Induced by Hookah (Waterpipe) Smoking in Young Adults. Circulation. 2019 May 7;139(19):2215-2224. doi: 10.1161/CIRCULATIONAHA.118.037375.

  PMID: 30764644 DERIVED

MeSH Terms

Conditions

Water Pipe Smoking

Interventions

Smoking Water Pipes

Condition Hierarchy (Ancestors)

Pipe Smoking; Smoking; Behavior

Intervention Hierarchy (Ancestors)

Smoking Pipes; Smoking Devices; Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• Florian Rader, MD

  Cedars-Sinai Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.D, M.Sc.

Study Record Dates

• First Submitted: January 13, 2015
• First Posted: August 6, 2018
• Study Start: January 1, 2015
• Primary Completion: March 1, 2020
• Study Completion: March 1, 2020
• Last Updated: February 4, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)