Effects of Hookah Smoking on Blood Flow to the Heart, Muscle and Skin

NCT02147665 | Completed

• 1 other identifier: Pro00031150
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

This is a pilot study on acute effects of Hookah smoking on the sympathetic neural control of the human cardiovascular system. Hookah smoking is known to transiently increase blood pressure and heart rate while decreasing heart rate variability suggesting - but not proving - sympathetic mediation. Here the investigators will directly measure the acute effects of Hookah smoking on sympathetic nerve activity with microneurography (intraneural microelectrodes) and quantify associated regional changes in vasomotor tone.

Conditions

Hookah Smoking

Keywords

Hookah; waterpipe; smoking; sympathetic

Outcome Measures

Primary Outcomes (1)

• Sympathetic nerve activity

  Multi-unit recordings of sympathetic nerve activity will be obtained with single-use sterile tungsten microelectrodes inserted selectively into muscle or skin nerve fascicles of the peritoneal nerve.

  At the initial study visit

Secondary Outcomes (1)

• Myocardial contrast echocardiography

  At the initial study visit

Other Outcomes (1)

• Venous Occlusion Plethysmography

  At the initial study visit

Study Arms (1)

Hookah smoking

EXPERIMENTAL

Healthy habitual Hookah smokers will undergo microneurography, myocardial contrast echocardiogram or venous occlusion plethysmography before and after Hookah smoking.

Other: Hookah smoking

Interventions

Hookah smoking OTHER

Subjects will smoke waterpipe in a controlled research environment.

Hookah smoking

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• to 39 years of age
• Habitual Hookah smoker defined as having smoked Hookah \>=12 times in the past 12 months
• Have not smoked cigarettes within the past 12 months

You may not qualify if:

• Exhaled carbon monoxide level greater than 10 ppm\* as evidence of current or recent cigarette (excluded if smoked cigarette within 12 months) or Hookah smoking (excluded if smoked Hookah within past 72 hours)
• History of cardiopulmonary disease
• Use of any prescription medication with exception of oral contraceptive pills
• History of psychiatric illness
• History of neurologic disease
• BMI ≥ 35
• Evidence of any of the above by physical examination, ECG or echocardiogram
• Smoked cigarette in the past 12 months
• History of illicit drug use
• Pregnant
• Any other condition(s) deemed by the physician investigators that put subjects at risk for participating in the study

Sponsors & Collaborators

• Cedars-Sinai Medical Center: lead

Study Sites (1)

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

Location

MeSH Terms

Conditions

Water Pipe Smoking; Smoking

Interventions

Smoking Water Pipes

Condition Hierarchy (Ancestors)

Pipe Smoking; Behavior

Intervention Hierarchy (Ancestors)

Smoking Pipes; Smoking Devices; Manufactured Materials; Technology, Industry, and Agriculture

Study Officials

• Ronald G Victor, MD

  Cedars-Sinai Medical Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: OTHER
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 30, 2014
• First Posted: May 28, 2014
• Study Start: March 1, 2013
• Primary Completion: March 1, 2016
• Study Completion: March 1, 2016
• Last Updated: January 13, 2020

Record last verified: 2015-11

Locations

US (1)