Plant-based Diets and Risk of Cancer in the Adventist Health Study-2
AHS-2
Cancer Epidemiology in Seventh-day Adventists
3 other identifiers
observational
96,000
1 country
1
Brief Summary
The Adventist Health Study-2 is a long-term study, exploring the links between lifestyle, diet, and disease outcomes among Seventh-day Adventists. More than 96,000 church members from the U.S. and Canada are participating in the current study, AHS-2, conducted by researchers at the Loma Linda University School of Public Health.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2002
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2002
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2013
CompletedFirst Submitted
Initial submission to the registry
June 29, 2018
CompletedFirst Posted
Study publicly available on registry
August 6, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2028
ExpectedJanuary 30, 2026
January 1, 2026
11.9 years
June 29, 2018
January 28, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Incident cases of breast cancer among subjects with documented dietary habits.
Incident cases of breast cancer as found by linkage with state cancer registries will allow calculation of hazard ratios comparing extreme quintiles of dietary intakes. The focus is on meats, soy, and dairy intakes.
Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.
Secondary Outcomes (1)
Incident cases of prostate cancer among subjects with documented dietary intakes.
Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.
Other Outcomes (1)
Incident cases of colorectal cancer among subjects with documented dietary habits.
Linkage with state cancer registries occurs periodically for 9 years, with first linkage at year 04 of study enrolment.
Study Arms (1)
Seventh-day Adventists
This is a prospective cohort study of 96,000 members of the Seventh-day Adventists Church in the United States and Canada age 30 and older at the time of enrollment who are proficient in English language.
Eligibility Criteria
The sample includes Seventh-day Adventist church members living in the USA and Canada who are 30 years and older, and who are sufficiently fluent in English to complete the lengthy lifestyle questionnaire. The study population is about 65% female. Approximately 25% of the cohort are Black/African Americans . Other ethnic minorities (e.g. Asian, Hispanic) are at much lower percentages (3-4 %).
You may qualify if:
- Member of a Seventh-day Adventist church \>30 years of age Ability to read English Live in the US or Canada
You may not qualify if:
- Less than 30 years of age
- Church members who did not complete the baseline questionnaire.
- Incarcerated or institutionalized people
- Non-English speakers
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Loma Linda Universitylead
- World Cancer Research Fund Internationalcollaborator
- Ardmore Institute of Healthcollaborator
- National Cancer Institute (NCI)collaborator
Study Sites (1)
Loma Linda University
Loma Linda, California, 92350, United States
Related Publications (2)
Butler TL, Fraser GE, Beeson WL, Knutsen SF, Herring RP, Chan J, Sabate J, Montgomery S, Haddad E, Preston-Martin S, Bennett H, Jaceldo-Siegl K. Cohort profile: The Adventist Health Study-2 (AHS-2). Int J Epidemiol. 2008 Apr;37(2):260-5. doi: 10.1093/ije/dym165. Epub 2007 Aug 27. No abstract available.
PMID: 17726038BACKGROUNDFraser GE, Jacobsen BK, Knutsen SF, Mashchak A, Lloren JI. Tomato consumption and intake of lycopene as predictors of the incidence of prostate cancer: the Adventist Health Study-2. Cancer Causes Control. 2020 Apr;31(4):341-351. doi: 10.1007/s10552-020-01279-z. Epub 2020 Feb 25.
PMID: 32100191DERIVED
Biospecimen
Buffy coat samples from a sample of the cohort (\~2500) are stored from which DNA material may be extracted when a study requires such data. Other stored bio-specimens from a sample of the cohort include adipose tissue, urine, blood, sputum, stool.
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gary E Fraser, MD,PhD
Loma Linda University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 29, 2018
First Posted
August 6, 2018
Study Start
February 1, 2002
Primary Completion
December 31, 2013
Study Completion (Estimated)
December 1, 2028
Last Updated
January 30, 2026
Record last verified: 2026-01
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, ICF, ANALYTIC CODE
- Time Frame
- on-going
- Access Criteria
- Data access will be given upon approval of proposal by the AHS-2 Review Committee.
Researchers must write a proposal describing how the data will be used and submit it to the Adventist Health Study data sharing committee for approval.